microRNA 21-mediated suppression of sprouty1 by Pokemon affects liver cancer cell growth and proliferation

• Published in: Journal of cellular biochemistry Vol. 114; no. 7; pp. 1625 - 1633
• Main Authors: Jin, Xiu-Li, Sun, Qin-Sheng, Liu, Feng, Yang, Hong-Wei, Liu, Min, Liu, Hong-Xia, Xu, Wei, Jiang, Yu-Yang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2013; Wiley Subscription Services, Inc
• Subjects: Adaptor Proteins, Signal Transducing; Blotting, Western; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cell Proliferation; Chromatin Immunoprecipitation; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Embryonic growth stage; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Humans; LIVER CANCER; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; microRNA 21; MicroRNAs - genetics; MicroRNAs - metabolism; Mutagenesis, Site-Directed; Phosphoproteins - genetics; Phosphoproteins - metabolism; POKEMON; Promoter Regions, Genetic - genetics; Real-Time Polymerase Chain Reaction; siRNA; Sprouty1; Transcription Factors - genetics; Transcription Factors - metabolism

Transcriptional repressor Pokemon is a critical factor in embryogenesis, development, cell proliferation, differentiation, and oncogenesis, thus behaving as an oncogene. Oncomine database suggests a potential correlation between the expressions of Pokemon and Sprouty1. This study investigated the re...