N‐acetylgalactosaminyltransferase‐4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal‐regulating kinase 1 N‐terminal dimerization

• Published in: Hepatology (Baltimore, Md.) Vol. 75; no. 6; pp. 1446 - 1460
• Main Authors: Zhou, Jiangqiao, Guo, Lina, Ma, Tengfei, Qiu, Tao, Wang, Sichen, Tian, Song, Zhang, Li, Hu, Fengjiao, Li, Wei, Liu, Zhen, Hu, Yufeng, Wang, Tianyu, Kong, Chenyang, Yang, Juan, Zhou, Junjie, Li, Hongliang
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.06.2022
• Subjects: Animal models; Animals; Apoptosis; Cell death; Correlation analysis; Dimerization; Gene expression; Glycosyltransferase; Hepatocytes; Hepatology; Ischemia; JNK protein; Kinases; Liver; Liver - pathology; Liver transplantation; MAP kinase; MAP Kinase Kinase Kinase 5 - metabolism; Mice; mRNA; N-Acetylgalactosaminyltransferases - genetics; Phenotypes; Phosphorylation; Polypeptide N-acetylgalactosaminyltransferase; Prognosis; Protein Multimerization; Reperfusion; Reperfusion Injury - genetics; Reperfusion Injury - prevention & control; Signal transduction; Surgery; Therapeutic targets

Background and Aims Ischemia‐reperfusion (I/R) injury is an inevitable complication of liver transplantation (LT) and compromises its prognosis. Glycosyltransferases have been recognized as promising targets for disease therapy, but their roles remain open for study in hepatic I/R (HIR) injury. Here...