Melatonin protects against paraquat‐induced damage during in vitro maturation of bovine oocytes
Paraquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little info...
Saved in:
| Published in | Journal of pineal research Vol. 66; no. 1; pp. e12532 - n/a |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2019
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Paraquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ‐induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro‐produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative CAT and GPx4 mRNA, and apoptotic‐related Bcl-2/Bax mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ‐exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ‐induced p38 mitogen‐activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl‐histone H3 lysine 4 (H3K4me3) and trimethyl‐histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ‐induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning. |
|---|---|
| AbstractList | Paraquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ‐induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro‐produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative
CAT
and
GPx4
mRNA, and apoptotic‐related
Bcl-2/Bax
mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ‐exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ‐induced p38 mitogen‐activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl‐histone H3 lysine 4 (H3K4me3) and trimethyl‐histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ‐induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning. Paraquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ‐induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro‐produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative CAT and GPx4 mRNA, and apoptotic‐related Bcl-2/Bax mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ‐exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ‐induced p38 mitogen‐activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl‐histone H3 lysine 4 (H3K4me3) and trimethyl‐histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ‐induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning. Paraquat (PQ), a broad-spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ-induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro-produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative CAT and GPx4 mRNA, and apoptotic-related Bcl-2/Bax mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ-exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ-induced p38 mitogen-activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl-histone H3 lysine 4 (H3K4me3) and trimethyl-histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ-induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning.Paraquat (PQ), a broad-spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ-induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro-produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative CAT and GPx4 mRNA, and apoptotic-related Bcl-2/Bax mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ-exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ-induced p38 mitogen-activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl-histone H3 lysine 4 (H3K4me3) and trimethyl-histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ-induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning. |
| Author | Pang, Yun‐Wei Hao, Hai‐Sheng Du, Wei‐Hua Zhao, Xue‐Ming Zhu, Hua‐Bin Zhao, Shan‐Jiang Wang, Lin Wang, Ya‐Chun Jiang, Xiao‐Long Wang, Yang‐Yang |
| Author_xml | – sequence: 1 givenname: Yun‐Wei orcidid: 0000-0002-7312-179X surname: Pang fullname: Pang, Yun‐Wei organization: Chinese Academy of Agricultural Sciences – sequence: 2 givenname: Xiao‐Long surname: Jiang fullname: Jiang, Xiao‐Long organization: China Agricultural University – sequence: 3 givenname: Ya‐Chun surname: Wang fullname: Wang, Ya‐Chun organization: China Agricultural University – sequence: 4 givenname: Yang‐Yang surname: Wang fullname: Wang, Yang‐Yang organization: Chinese Academy of Agricultural Sciences – sequence: 5 givenname: Hai‐Sheng surname: Hao fullname: Hao, Hai‐Sheng organization: Chinese Academy of Agricultural Sciences – sequence: 6 givenname: Shan‐Jiang surname: Zhao fullname: Zhao, Shan‐Jiang organization: Chinese Academy of Agricultural Sciences – sequence: 7 givenname: Wei‐Hua surname: Du fullname: Du, Wei‐Hua organization: Chinese Academy of Agricultural Sciences – sequence: 8 givenname: Xue‐Ming surname: Zhao fullname: Zhao, Xue‐Ming organization: Chinese Academy of Agricultural Sciences – sequence: 9 givenname: Lin surname: Wang fullname: Wang, Lin organization: Chinese Academy of Agricultural Sciences – sequence: 10 givenname: Hua‐Bin surname: Zhu fullname: Zhu, Hua‐Bin email: zhuhuabin@caas.cn organization: Chinese Academy of Agricultural Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30320949$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kL1OwzAUhS1UBOVn4AWQRxhCrx0njkdU8SsQDCCxRY7jVEaJ3doOqBuPwDPyJAQKDEhwl7N850j320Ij66xGaI_AERlu8jg3R4RmKV1DY5IDJMDFwwiNgTOapCCKTbQVwiMAFEWRb6DNFFIKgokxkte6ldFZY_Hcu6hVDFjOpLEh4rn0ctHL-PbyamzdK13jWnZypnHde2NneCg9megd7mTsvYzGWewaXLknYzV2Ti2jDjtovZFt0LtfuY3uT0_upufJ1c3ZxfT4KlGpIDTJG5ZTVkhBa86UpnUjOFeCsYYznmeqYoqqPK8HOAMNQDlnTaGqhmQZsKJKt9HBanf4Y9HrEMvOBKXbVlrt-lBSQoEIYCkZ0P0vtK86XZdzbzrpl-W3lgE4XAHKuxC8bn4QAuWH8nJQXn4qH9jJL1aZ-Okiemna_xrPptXLv6fLy9uLVeMd1XyTWw |
| CitedBy_id | crossref_primary_10_1016_j_ecoenv_2023_115186 crossref_primary_10_3390_ani13091475 crossref_primary_10_1080_15384101_2024_2402190 crossref_primary_10_3390_ijerph16214137 crossref_primary_10_1016_j_theriogenology_2023_06_022 crossref_primary_10_1080_10799893_2020_1756326 crossref_primary_10_1016_j_ecoenv_2021_112711 crossref_primary_10_1021_envhealth_4c00243 crossref_primary_10_3389_fcell_2020_631104 crossref_primary_10_1016_j_biopha_2021_112001 crossref_primary_10_1016_j_bbcan_2023_188890 crossref_primary_10_2478_fv_2019_0011 crossref_primary_10_3390_ani10020209 crossref_primary_10_1186_s40104_022_00809_w crossref_primary_10_3390_ijms222111704 crossref_primary_10_1016_j_theriogenology_2022_07_017 crossref_primary_10_1155_2022_5623555 crossref_primary_10_1016_j_lfs_2019_116810 crossref_primary_10_1017_S0967199421000721 crossref_primary_10_3389_fphys_2024_1501334 crossref_primary_10_1007_s11033_020_05607_z crossref_primary_10_3390_ani12070832 crossref_primary_10_3390_ijms20122956 crossref_primary_10_3389_fcell_2021_803181 crossref_primary_10_1016_j_theriogenology_2021_03_011 crossref_primary_10_14712_fb2023069010006 crossref_primary_10_1038_s41598_020_59161_6 crossref_primary_10_18632_aging_202323 crossref_primary_10_1016_j_envpol_2021_118445 crossref_primary_10_3390_antiox10121867 crossref_primary_10_1111_jpi_12718 crossref_primary_10_3390_ijms23147815 crossref_primary_10_1002_tox_22851 crossref_primary_10_1002_ptr_7071 crossref_primary_10_1097_RD9_0000000000000063 crossref_primary_10_1111_jpi_12635 crossref_primary_10_1016_j_ecoenv_2022_113622 crossref_primary_10_1016_j_molp_2023_10_018 crossref_primary_10_1016_j_repbio_2024_100888 crossref_primary_10_1093_biolre_ioae077 crossref_primary_10_3390_ijms22010168 crossref_primary_10_1016_j_freeradbiomed_2023_08_023 crossref_primary_10_1371_journal_pone_0267598 crossref_primary_10_1016_j_anireprosci_2020_106685 crossref_primary_10_3390_ijms21031135 crossref_primary_10_1111_jpi_12627 crossref_primary_10_3390_cells9061550 crossref_primary_10_1016_j_ecoenv_2023_114747 crossref_primary_10_1186_s12958_022_00938_x crossref_primary_10_1152_ajpendo_00057_2019 crossref_primary_10_1152_ajpcell_00339_2024 crossref_primary_10_1186_s40104_021_00605_y crossref_primary_10_1155_2021_5573357 crossref_primary_10_3390_molecules28134940 crossref_primary_10_1016_j_theriogenology_2021_11_018 crossref_primary_10_3389_fvets_2024_1444578 |
| Cites_doi | 10.1021/es503712c 10.1111/jpi.12264 10.1034/j.1600-079X.2001.310404.x 10.1016/j.cbpc.2009.11.003 10.1080/17425255.2016.1214712 10.1016/j.reprotox.2005.03.006 10.1186/1477-7827-3-28 10.1111/asj.12779 10.1007/s11259-008-9071-9 10.1016/j.neulet.2012.07.001 10.1186/1757-2215-5-5 10.1016/j.neuro.2011.05.018 10.1111/jpi.12297 10.1016/j.toxlet.2014.01.039 10.1111/jpi.12396 10.1038/s41594-017-0013-5 10.1210/en.2004-0990 10.2527/1994.722434x 10.1002/(SICI)1098-2795(199708)47:4<456::AID-MRD13>3.0.CO;2-U 10.1111/jpi.12163 10.1016/j.acthis.2017.01.003 10.1016/j.ejphar.2014.09.033 10.1093/toxsci/kfl013 10.1016/j.theriogenology.2009.04.017 10.1097/01.hjh.0000358832.41181.bf 10.1038/nature19361 10.1002/mrd.21295 10.4062/biomolther.2014.115 10.1080/10409230903044914 10.1111/jpi.12267 10.1093/humupd/dmt054 10.5604/17322693.1221001 10.1038/nrg3142 10.1016/0006-2952(96)00055-X 10.1093/biolre/iox185 10.3390/metabo7020022 10.1007/s12011-015-0449-6 10.1155/2017/4652695 10.1371/journal.pone.0162722 10.1093/mollus/68.2.181 10.1111/j.1600-079X.2012.01014.x 10.1371/journal.pone.0093837 10.1095/biolreprod.108.075655 10.3390/ijms17030341 10.1155/2016/8923860 10.1111/j.1600-079X.2008.00565.x 10.1016/j.theriogenology.2012.06.019 10.1186/s12974-018-1157-x 10.1369/0022155412463923 10.1007/s12035-015-9198-y 10.1111/jpi.12162 10.1111/j.1600-079X.2011.00866.x 10.1016/j.placenta.2016.04.019 10.1016/S0166-445X(99)00080-6 10.1016/j.gene.2012.04.040 10.1016/j.cbi.2013.09.010 10.3390/ijms151018484 10.1089/ars.2007.1964 10.1507/endocrj.EJ12-0263 10.1111/j.1476-5381.2012.01870.x 10.3109/10715762.2014.899694 |
| ContentType | Journal Article |
| Copyright | 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| Copyright_xml | – notice: 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd – notice: 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1111/jpi.12532 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1600-079X |
| EndPage | n/a |
| ExternalDocumentID | 30320949 10_1111_jpi_12532 JPI12532 |
| Genre | article Journal Article |
| GrantInformation_xml | – fundername: the China Agriculture Research System funderid: CARS-36 – fundername: the National Natural Science Foundation of China funderid: 31501957 – fundername: the Agricultural Science and Technology Innovation Program funderid: ASTIP-IAS06 – fundername: the Chinese Academy of Agricultural Sciences Foundation funderid: 2018-YWF-YTS-14 – fundername: the Agricultural Science and Technology Innovation Program grantid: ASTIP-IAS06 – fundername: the National Natural Science Foundation of China grantid: 31501957 – fundername: the China Agriculture Research System grantid: CARS-36 – fundername: the Chinese Academy of Agricultural Sciences Foundation grantid: 2018-YWF-YTS-14 |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 186 1OB 1OC 29L 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAKAS AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACRPL ACSCC ACUHS ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZCM ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFWVQ AFZJQ AHBTC AHEFC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BQCPF BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EBC EBD EBS EBX EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K W8V W99 WBKPD WIH WIJ WIK WNSPC WOHZO WOW WQJ WRC WXI WXSBR WYISQ XG1 YFH YUY ZZTAW ~IA ~WT AAYXX AEYWJ AGHNM AGQPQ AGYGG CITATION AAMMB AEFGJ AGXDD AIDQK AIDYY NPM 7X8 |
| ID | FETCH-LOGICAL-c3912-6f46248a92d74ce2df977c944f74765cb4c2c66d39150e002774f8cbf155048b3 |
| IEDL.DBID | DR2 |
| ISSN | 0742-3098 1600-079X |
| IngestDate | Fri Jul 11 07:40:04 EDT 2025 Mon Jul 21 05:58:31 EDT 2025 Thu Apr 24 23:10:59 EDT 2025 Tue Jul 01 01:05:22 EDT 2025 Wed Jan 22 16:23:08 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | bovine oxidative damage paraquat oocyte maturation melatonin |
| Language | English |
| License | 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3912-6f46248a92d74ce2df977c944f74765cb4c2c66d39150e002774f8cbf155048b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-7312-179X |
| PMID | 30320949 |
| PQID | 2120190431 |
| PQPubID | 23479 |
| PageCount | 15 |
| ParticipantIDs | proquest_miscellaneous_2120190431 pubmed_primary_30320949 crossref_primary_10_1111_jpi_12532 crossref_citationtrail_10_1111_jpi_12532 wiley_primary_10_1111_jpi_12532_JPI12532 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | January 2019 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: January 2019 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of pineal research |
| PublicationTitleAlternate | J Pineal Res |
| PublicationYear | 2019 |
| References | 2017; 119 2009; 44 2017; 7 2000; 49 2009; 81 2017; 88 1997; 47 2013; 61 2013; 206 2005; 20 2018; e12477 2013; 168 2015; 748 2016; 2016 2016; 70 2012; 13 1996; 38 2012; 524 2014; 22 2014; 20 2013; 54 2005; 146 2016; 43 2014; 15 2013; 60 2014; 57 2010; 151 2014; 9 1994; 72 2014; 55 2006; 92 2015; 59 2017; 62 2017; 2017 2014; 48 2016; 53 1996; 51 2011; 32 2008; 10 2011; 78 2016; 17 2012; 78 2014; 230 2009; 27 2012; 503 2018; 25 2016; 11 2009; 33 2009; 72 2016; 537 2002; 68 2017; 13 2011; 51 2008; 45 2016; 60 2005; 3 2016; 170 2018; 98 2012; 5 2018; 15 2001; 31 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_60_1 e_1_2_7_17_1 e_1_2_7_62_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_64_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_52_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_54_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_56_1 e_1_2_7_37_1 e_1_2_7_58_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_61_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_63_1 e_1_2_7_12_1 e_1_2_7_65_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_29_1 Tsatsakis AM (e_1_2_7_5_1) 1996; 38 Lan M (e_1_2_7_31_1) 2018; 12477 e_1_2_7_51_1 Medina‐Leendertz S (e_1_2_7_44_1) 2014; 55 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_55_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_57_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_59_1 e_1_2_7_38_1 |
| References_xml | – volume: 503 start-page: 1 year: 2012 end-page: 11 article-title: Gene regulation by melatonin linked to epigenetic phenomena publication-title: Gene – volume: 59 start-page: 403 year: 2015 end-page: 419 article-title: Melatonin: an ancient molecule that makes oxygen metabolically tolerable publication-title: J Pineal Res – volume: e12477 year: 2018 article-title: Melatonin protects against defects induced by deoxynivalenol during mouse oocyte maturation publication-title: J Pineal Res – volume: 206 start-page: 248 year: 2013 end-page: 255 article-title: Paraquat inhibits cell viability via enhanced oxidative stress and apoptosis in human neural progenitor cells publication-title: Chem Biol Interact – volume: 15 start-page: 18484 year: 2014 end-page: 18495 article-title: Transcriptional regulation of programmed hypertension by melatonin: an epigenetic perspective publication-title: Int J Mol Sci – volume: 62 start-page: e12396 issue: 3 year: 2017 article-title: Melatonin protects oocyte quality from Bisphenol A‐induced deterioration in the mouse publication-title: J Pineal Res – volume: 2017 start-page: 4652695 year: 2017 article-title: Liver X Receptor Agonist TO901317 Attenuates Paraquat‐Induced Acute Lung Injury through Inhibition of NF‐kappaB and JNK/p38 MAPK Signal Pathways publication-title: Biomed Res Int – volume: 92 start-page: 507 year: 2006 end-page: 515 article-title: Low concentrations of paraquat induces early activation of extracellular signal‐regulated kinase 1/2, protein kinase B, and c‐Jun N‐terminal kinase 1/2 pathways: role of c‐Jun N‐terminal kinase in paraquat‐induced cell death publication-title: Toxicol Sci – volume: 25 start-page: 73 year: 2018 end-page: 82 article-title: MLL2 conveys transcription‐independent H3K4 trimethylation in oocytes publication-title: Nat Struct Mol Biol – volume: 748 start-page: 157 year: 2015 end-page: 165 article-title: Cytoprotective effect of melatonin against hypoxia/serum deprivation‐induced cell death of bone marrow mesenchymal stem cells in vitro publication-title: Eur J Pharmacol – volume: 27 start-page: S17 year: 2009 end-page: S20 article-title: The circadian melatonin rhythm and its modulation: possible impact on hypertension publication-title: J Hypertens Suppl – volume: 524 start-page: 35 year: 2012 end-page: 39 article-title: 5'‐Aza‐dC sensitizes paraquat toxic effects on PC12 cell publication-title: Neurosci Lett – volume: 168 start-page: 46 year: 2013 end-page: 59 article-title: The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat‐induced toxicity in vitro and in vivo publication-title: Br J Pharmacol – volume: 54 start-page: 1 year: 2013 end-page: 14 article-title: A review of the molecular aspects of melatonin's anti‐inflammatory actions: recent insights and new perspectives publication-title: J Pineal Res – volume: 48 start-page: 623 year: 2014 end-page: 640 article-title: New insights into antioxidant strategies against paraquat toxicity publication-title: Free Radic Res – volume: 151 start-page: 240 year: 2010 end-page: 247 article-title: Paraquat‐induced oxidative stress response during amphibian early embryonic development publication-title: Comp Biochem Physiol C Toxicol Pharmacol – volume: 78 start-page: 250 year: 2011 end-page: 262 article-title: Evidence of melatonin synthesis in the cumulus oocyte complexes and its role in enhancing oocyte maturation in vitro in cattle publication-title: Mol Reprod Dev – volume: 72 start-page: 434 year: 1994 end-page: 437 article-title: Effect of free amino acids and vitamins on cleavage and developmental rate of bovine zygotes in vitro publication-title: J Anim Sci – volume: 45 start-page: 125 year: 2008 end-page: 132 article-title: Acute sleep‐promoting action of the melatonin agonist, ramelteon, in the rat publication-title: J Pineal Res – volume: 49 start-page: 171 year: 2000 end-page: 179 article-title: Paraquat induced embryotoxicity on Xenopus laevis development publication-title: Aquat Toxicol – volume: 9 start-page: e93837 year: 2014 article-title: Paraquat‐induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF‐kappaB‐IL‐6/TNF‐alpha positive‐feedback circuit publication-title: PLoS ONE – volume: 22 start-page: 503 year: 2014 end-page: 509 article-title: Paraquat induces apoptosis through cytochrome C release and ERK activation publication-title: Biomol Ther – volume: 72 start-page: 612 year: 2009 end-page: 623 article-title: Influence of metabolic status on oocyte quality and follicular characteristics at different postpartum periods in primiparous rabbit does publication-title: Theriogenology – volume: 61 start-page: 75 year: 2013 end-page: 89 article-title: H3K9 trimethylation precedes DNA methylation during sheep oogenesis: HDAC1, SUV39H1, G9a, HP1, and Dnmts are involved in these epigenetic events publication-title: J Histochem Cytochem – volume: 51 start-page: 1095 year: 1996 end-page: 1099 article-title: Paraquat toxicity and oxidative damage. Reduction by melatonin publication-title: Biochem Pharmacol – volume: 17 start-page: 341 year: 2016 article-title: Oncostatic‐Cytoprotective Effect of Melatonin and Other Bioactive Molecules: A Common Target in Mitochondrial Respiration publication-title: Int J Mol Sci – volume: 146 start-page: 1541 year: 2005 end-page: 1552 article-title: Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin‐releasing hormone system publication-title: Endocrinology – volume: 20 start-page: 239 year: 2005 end-page: 246 article-title: Effects of paraquat on development of preimplantation embryos in vivo and in vitro publication-title: Reprod Toxicol – volume: 7 start-page: E22 year: 2017 article-title: Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease publication-title: Metabolites – volume: 230 start-page: 85 year: 2014 end-page: 103 article-title: Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases–a mechanistic approach publication-title: Toxicol Lett – volume: 13 start-page: 97 year: 2012 end-page: 109 article-title: Epigenetics and the environment: emerging patterns and implications publication-title: Nat Rev Genet – volume: 15 start-page: 119 year: 2018 article-title: Acute dose of melatonin via Nrf2 dependently prevents acute ethanol‐induced neurotoxicity in the developing rodent brain publication-title: J Neuroinflammation – volume: 68 start-page: 181 year: 2002 end-page: 186 article-title: Oocyte degeneration and altered ovipository activity induced by paraquat in the freshwater snail physa fontinalis (Gastropoda: Pulmonata) publication-title: J Molluscan Stud – volume: 57 start-page: 131 year: 2014 end-page: 146 article-title: Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions publication-title: J Pineal Res – volume: 78 start-page: 1517 year: 2012 end-page: 1526 article-title: Melatonin suppresses apoptosis and stimulates progesterone production by bovine granulosa cells via its receptors (MT1 and MT2) publication-title: Theriogenology – volume: 2016 start-page: 8923860 year: 2016 article-title: Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells publication-title: Oxid Med Cell Longev – volume: 537 start-page: 553 year: 2016 end-page: 557 article-title: Allelic reprogramming of the histone modification H3K4me3 in early mammalian development publication-title: Nature – volume: 20 start-page: 293 year: 2014 end-page: 307 article-title: Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology publication-title: Hum Reprod Update – volume: 60 start-page: 155 year: 2016 end-page: 166 article-title: Melatonin inhibits paraquat‐induced cell death in bovine preimplantation embryos publication-title: J Pineal Res – volume: 3 start-page: 28 year: 2005 article-title: Role of oxidative stress in female reproduction publication-title: Reprod Biol Endocrinol – volume: 31 start-page: 308 year: 2001 end-page: 313 article-title: Effects of melatonin on paraquat or ultraviolet light exposure‐induced DNA damage publication-title: J Pineal Res – volume: 57 start-page: 239 year: 2014 end-page: 247 article-title: Beneficial effects of melatonin on bovine oocytes maturation: a mechanistic approach publication-title: J Pineal Res – volume: 32 start-page: 586 year: 2011 end-page: 595 article-title: Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration publication-title: Neurotoxicology – volume: 11 start-page: e0162722 year: 2016 article-title: Preovulatory aging in vivo and in vitro affects maturation rates, abundance of selected proteins, histone methylation pattern and spindle integrity in murine oocytes publication-title: PLoS ONE – volume: 59 start-page: 292 year: 2015 end-page: 307 article-title: Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis publication-title: J Pineal Res – volume: 5 start-page: 5 year: 2012 article-title: The role of melatonin as an antioxidant in the follicle publication-title: J Ovarian Res – volume: 60 start-page: 1 year: 2013 end-page: 13 article-title: Melatonin as a free radical scavenger in the ovarian follicle publication-title: Endocr J – volume: 98 start-page: 286 year: 2018 end-page: 298 article-title: Melatonin protects oocytes from MEHP exposure‐induced meiosis defects in porcine publication-title: Biol Reprod – volume: 47 start-page: 456 year: 1997 end-page: 467 article-title: Timing of meiotic progression in bovine oocytes and its effect on early embryo development publication-title: Mol Reprod Dev – volume: 38 start-page: 113 year: 1996 end-page: 117 article-title: Experience with acute paraquat poisoning in Crete publication-title: Vet Hum Toxicol – volume: 70 start-page: 1059 year: 2016 end-page: 1067 article-title: Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells publication-title: Postepy Hig Med Dosw – volume: 51 start-page: 94 year: 2011 end-page: 103 article-title: Melatonin protects against oxidative stress in granular corneal dystrophy type 2 corneal fibroblasts by mechanisms that involve membrane melatonin receptors publication-title: J Pineal Res – volume: 88 start-page: 1298 year: 2017 end-page: 1310 article-title: Effects of melatonin on maturation, histone acetylation, autophagy of porcine oocytes and subsequent embryonic development publication-title: Anim Sci J – volume: 81 start-page: 445 year: 2009 end-page: 456 article-title: Melatonin and reproduction revisited publication-title: Biol Reprod – volume: 119 start-page: 220 year: 2017 end-page: 227 article-title: Effects of melatonin in rats in the initial third stage of pregnancy exposed to sub‐lethal doses of herbicides publication-title: Acta Histochem – volume: 44 start-page: 175 year: 2009 end-page: 200 article-title: Reducing oxidative/nitrosative stress: a newly‐discovered genre for melatonin publication-title: Crit Rev Biochem Mol Biol – volume: 55 start-page: 352 year: 2014 end-page: 364 article-title: Longterm melatonin administration alleviates paraquat mediated oxidative stress in Drosophila melanogaster publication-title: Invest Clin – volume: 170 start-page: 152 year: 2016 end-page: 164 article-title: The protective effects of melatonin against oxidative stress and inflammation induced by acute cadmium exposure in mice testis publication-title: Biol Trace Elem Res – volume: 48 start-page: 11688 year: 2014 end-page: 11695 article-title: Abnormal ovarian DNA methylation programming during gonad maturation in wild contaminated fish publication-title: Environ Sci Technol – volume: 53 start-page: 2169 year: 2016 end-page: 2188 article-title: Paraquat induces cell death through impairing mitochondrial membrane permeability publication-title: Mol Neurobiol – volume: 33 start-page: 49 year: 2009 end-page: 56 article-title: Expression analysis of melatonin receptor subtypes in the ovary of domestic chicken publication-title: Vet Res Commun – volume: 43 start-page: 41 year: 2016 end-page: 46 article-title: Paraquat inhibits progesterone synthesis in human placental mitochondria publication-title: Placenta – volume: 10 start-page: 1375 year: 2008 end-page: 1403 article-title: Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications publication-title: Antioxid Redox Signal – volume: 13 start-page: 545 year: 2017 end-page: 554 article-title: A review of the protective effect of melatonin in pesticide‐induced toxicity publication-title: Expert Opin Drug Metab Toxicol – ident: e_1_2_7_57_1 doi: 10.1021/es503712c – ident: e_1_2_7_21_1 doi: 10.1111/jpi.12264 – ident: e_1_2_7_42_1 doi: 10.1034/j.1600-079X.2001.310404.x – ident: e_1_2_7_10_1 doi: 10.1016/j.cbpc.2009.11.003 – ident: e_1_2_7_3_1 doi: 10.1080/17425255.2016.1214712 – ident: e_1_2_7_9_1 doi: 10.1016/j.reprotox.2005.03.006 – ident: e_1_2_7_36_1 doi: 10.1186/1477-7827-3-28 – ident: e_1_2_7_56_1 doi: 10.1111/asj.12779 – ident: e_1_2_7_25_1 doi: 10.1007/s11259-008-9071-9 – ident: e_1_2_7_59_1 doi: 10.1016/j.neulet.2012.07.001 – ident: e_1_2_7_20_1 doi: 10.1186/1757-2215-5-5 – volume: 12477 year: 2018 ident: e_1_2_7_31_1 article-title: Melatonin protects against defects induced by deoxynivalenol during mouse oocyte maturation publication-title: J Pineal Res – ident: e_1_2_7_58_1 doi: 10.1016/j.neuro.2011.05.018 – ident: e_1_2_7_11_1 doi: 10.1111/jpi.12297 – ident: e_1_2_7_48_1 doi: 10.1016/j.toxlet.2014.01.039 – ident: e_1_2_7_30_1 doi: 10.1111/jpi.12396 – volume: 55 start-page: 352 year: 2014 ident: e_1_2_7_44_1 article-title: Longterm melatonin administration alleviates paraquat mediated oxidative stress in Drosophila melanogaster publication-title: Invest Clin – ident: e_1_2_7_61_1 doi: 10.1038/s41594-017-0013-5 – ident: e_1_2_7_28_1 doi: 10.1210/en.2004-0990 – ident: e_1_2_7_35_1 doi: 10.2527/1994.722434x – ident: e_1_2_7_33_1 doi: 10.1002/(SICI)1098-2795(199708)47:4<456::AID-MRD13>3.0.CO;2-U – ident: e_1_2_7_27_1 doi: 10.1111/jpi.12163 – ident: e_1_2_7_45_1 doi: 10.1016/j.acthis.2017.01.003 – ident: e_1_2_7_52_1 doi: 10.1016/j.ejphar.2014.09.033 – ident: e_1_2_7_47_1 doi: 10.1093/toxsci/kfl013 – ident: e_1_2_7_34_1 doi: 10.1016/j.theriogenology.2009.04.017 – ident: e_1_2_7_14_1 doi: 10.1097/01.hjh.0000358832.41181.bf – ident: e_1_2_7_60_1 doi: 10.1038/nature19361 – ident: e_1_2_7_26_1 doi: 10.1002/mrd.21295 – ident: e_1_2_7_49_1 doi: 10.4062/biomolther.2014.115 – ident: e_1_2_7_19_1 doi: 10.1080/10409230903044914 – ident: e_1_2_7_29_1 doi: 10.1111/jpi.12267 – ident: e_1_2_7_17_1 doi: 10.1093/humupd/dmt054 – ident: e_1_2_7_15_1 doi: 10.5604/17322693.1221001 – ident: e_1_2_7_54_1 doi: 10.1038/nrg3142 – ident: e_1_2_7_41_1 doi: 10.1016/0006-2952(96)00055-X – ident: e_1_2_7_32_1 doi: 10.1093/biolre/iox185 – ident: e_1_2_7_55_1 doi: 10.3390/metabo7020022 – ident: e_1_2_7_24_1 doi: 10.1007/s12011-015-0449-6 – ident: e_1_2_7_51_1 doi: 10.1155/2017/4652695 – ident: e_1_2_7_63_1 doi: 10.1371/journal.pone.0162722 – ident: e_1_2_7_7_1 doi: 10.1093/mollus/68.2.181 – ident: e_1_2_7_23_1 doi: 10.1111/j.1600-079X.2012.01014.x – ident: e_1_2_7_50_1 doi: 10.1371/journal.pone.0093837 – ident: e_1_2_7_13_1 doi: 10.1095/biolreprod.108.075655 – ident: e_1_2_7_16_1 doi: 10.3390/ijms17030341 – ident: e_1_2_7_2_1 doi: 10.1155/2016/8923860 – ident: e_1_2_7_12_1 doi: 10.1111/j.1600-079X.2008.00565.x – ident: e_1_2_7_22_1 doi: 10.1016/j.theriogenology.2012.06.019 – ident: e_1_2_7_53_1 doi: 10.1186/s12974-018-1157-x – ident: e_1_2_7_62_1 doi: 10.1369/0022155412463923 – ident: e_1_2_7_46_1 doi: 10.1007/s12035-015-9198-y – ident: e_1_2_7_18_1 doi: 10.1111/jpi.12162 – ident: e_1_2_7_43_1 doi: 10.1111/j.1600-079X.2011.00866.x – ident: e_1_2_7_6_1 doi: 10.1016/j.placenta.2016.04.019 – ident: e_1_2_7_8_1 doi: 10.1016/S0166-445X(99)00080-6 – ident: e_1_2_7_64_1 doi: 10.1016/j.gene.2012.04.040 – ident: e_1_2_7_40_1 doi: 10.1016/j.cbi.2013.09.010 – ident: e_1_2_7_65_1 doi: 10.3390/ijms151018484 – ident: e_1_2_7_37_1 doi: 10.1089/ars.2007.1964 – volume: 38 start-page: 113 year: 1996 ident: e_1_2_7_5_1 article-title: Experience with acute paraquat poisoning in Crete publication-title: Vet Hum Toxicol – ident: e_1_2_7_38_1 doi: 10.1507/endocrj.EJ12-0263 – ident: e_1_2_7_39_1 doi: 10.1111/j.1476-5381.2012.01870.x – ident: e_1_2_7_4_1 doi: 10.3109/10715762.2014.899694 |
| SSID | ssj0008886 |
| Score | 2.4820473 |
| Snippet | Paraquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including... Paraquat (PQ), a broad-spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e12532 |
| SubjectTerms | bovine melatonin oocyte maturation oxidative damage paraquat |
| Title | Melatonin protects against paraquat‐induced damage during in vitro maturation of bovine oocytes |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjpi.12532 https://www.ncbi.nlm.nih.gov/pubmed/30320949 https://www.proquest.com/docview/2120190431 |
| Volume | 66 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEA6LJy--H-uLKCJeuuw22XaDJxFFFxQRBQ9CSdJUim677naF9eRP8Df6S5xJH75BvPWQpmlnkvm-6eQLIduszbmQTe2YlqscrnzmSJ9FTggGiVDvnFsR19Mz7_iKd6_b1zWyV-6FyfUhqoQbzgy7XuMEl2r4cZL34wZEZ4brL9ZqISC6eJeOAmbn5RKcrsOaolOoCtkqnvLOz7HoG8D8jFdtwDmaJjflUPM6k7vGKFMN_fRFxfGf7zJDpgogSvdzz5klNZPMkfn9BEh4b0x3qC0NtTn3eSJPsWQOE7e00HUYUnkrY4CWFLXDH0Yye31-AXoPjhLSUPZglaL5DkgKNz3G2SClPdQQtY5A04gqTGUYmqZ6DGh3gVwdHV4eHDvF2QyOZqLlOl4ERuQdKdzQ59q4YQRAUgvOI-AnXlsrrl3teSHqzzcNkl-fRx2tIqREvKPYIplI0sQsEwoMMoQQKaWrGJDTlvANAhcUFgyFFO062S2tFOhCuBzPz7gPKgLTjwP7-epkq2raz9U6fmq0WZo6gLmEP0hkYtLRMIAwjlvrAVPVyVLuA1U3DE-aF1zAaKwlf-8_6J6f2IuVvzddJZP46Dy3s0YmssHIrAPaydSGdes3ufr6ZA |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB0heoBL-S4LpRiEKi5Z7cbeZC31giho-ViEEEhcqsh2HLSCTZYlW4me-An8xv4SZpxkgbZIFbccbMvJzHjem9jPAFu8JYRUDePZpq89oUPuqZAnXowGSUjvXDgR1-5J0LkQh5etywn4Vp2FKfQhxgU3igy3XlOAU0H6ZZQPenVMzxwX4A90ozcp538_exaPQm4XFCKcvscbsl3qCrl9PFXX19noL4j5GrG6lLM_Az-qyRY7Ta7ro1zXza8_dBzf-zaz8LHEomyncJ45mLDpPCzspMjD-_fsK3O7Q13ZfQFUl3bNUe2WldIOd0xdqR6iS0by4bcjlf9-eESGj74Ss1j1caFixSFIhp1-9vJhxvokI-p8gWUJ01TNsCzLzD0C3kW42N873-145fUMnuGy6XtBgnYUbSX9OBTG-nGCWNJIIRKkKEHLaGF8EwQxSdA3LPHfUCRtoxNiRaKt-RJMpllql4EhiYwxSyrla478tClDS9iFtAVjqWSrBtuVmSJTapfTFRo30ZjDDHqR-3w12Bw3HRSCHf9qtFHZOsJwon8kKrXZ6C7CTE6n6xFW1eBT4QTjYThdNi-FxNk4U749fnR4euAeVv6_6TpMdc67x9HxwcnRKkzTNIpSz2eYzIcju4bgJ9dfnI8_AVrM_oA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4hkKpeSilt2ZaCqaqql6x2Y2-yFicErHgLVUXiUCnyE61gky1kkeDUn9DfyC_pjJMspQ-p4paDbTmZGc_3TezPAB94TwipOiZy3VhHQqc8Uin3kUWDeNI7F0HE9fAo2TkRe6e90xlYb87CVPoQ04IbRUZYrynAx9b_GuTjYRuzM8f1d04kHUn3Nmx9vteOQmqXVBqcccQ7sl_LCoVtPE3Xh8noD4T5ELCGjDOYh6_NXKuNJuftSanb5vY3GcdHvsxzeFYjUbZRuc4CzLj8BSxu5MjCRzfsIwt7Q0PRfRHUIe2Zo8otq4Udrpg6U0PElozEw79NVHn3_Qfye_QUy6wa4TLFqiOQDDtdD8vLgo1IRDR4Ais801TLcKwozA3C3ZdwMtj-srkT1ZczRIbLbhwlHq0o-krGNhXGxdYjkjRSCI8EJekZLUxsksSSAH3HEftNhe8b7YkTib7mr2A2L3K3BAwppMUcqVSsObLTrkwdIRdSFrRSyV4LPjVWykytXE4XaFxkUwYzHmbh87Xg_bTpuJLr-FujtcbUGQYT_SFRuSsmVxnmcTpbj6CqBa8rH5gOw-mqeSkkziZY8t_jZ3vHu-Hhzf83XYUnx1uD7GD3aP8tPKVZVHWeZZgtLyfuHSKfUq8ED_8JZjj9Lw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Melatonin+protects+against+paraquat-induced+damage+during+in+vitro+maturation+of+bovine+oocytes&rft.jtitle=Journal+of+pineal+research&rft.au=Pang%2C+Yun-Wei&rft.au=Jiang%2C+Xiao-Long&rft.au=Wang%2C+Ya-Chun&rft.au=Wang%2C+Yang-Yang&rft.date=2019-01-01&rft.eissn=1600-079X&rft.volume=66&rft.issue=1&rft.spage=e12532&rft_id=info:doi/10.1111%2Fjpi.12532&rft_id=info%3Apmid%2F30320949&rft.externalDocID=30320949 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0742-3098&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0742-3098&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0742-3098&client=summon |