Higher homocysteine and lower betaine increase the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C

• Published in: Diabetes/metabolism research and reviews Vol. 29; no. 8; pp. 607 - 617
• Main Authors: Chen, Li, Chen, Yan-ming, Wang, Li-jun, Wei, Jun, Tan, Yao-zong, Zhou, Jing-ya, Yang, Yang, Chen, Yu-ming, Ling, Wen-hua, Zhu, Hui-lian
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2013; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; betaine; Betaine - blood; Biomarkers - blood; Case-Control Studies; choline; diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetic Angiopathies - genetics; Female; Genotype; homocysteine; Homocysteine - blood; Humans; Male; microangiopathy; Middle Aged; Odds Ratio; Phosphatidylethanolamine N-Methyltransferase - genetics; polymorphism; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; homocysteine; choline; microangiopathy; polymorphism; betaine; diabetes

Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This s...