Higher homocysteine and lower betaine increase the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C

Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This s...

Full description

Saved in:
Bibliographic Details
Published inDiabetes/metabolism research and reviews Vol. 29; no. 8; pp. 607 - 617
Main Authors Chen, Li, Chen, Yan-ming, Wang, Li-jun, Wei, Jun, Tan, Yao-zong, Zhou, Jing-ya, Yang, Yang, Chen, Yu-ming, Ling, Wen-hua, Zhu, Hui-lian
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.11.2013
Wiley Subscription Services, Inc
Subjects
Adult
Aged
Aged, 80 and over
betaine
Betaine - blood
Biomarkers - blood
Case-Control Studies
choline
diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetic Angiopathies - genetics
Female
Genotype
homocysteine
Homocysteine - blood
Humans
Male
microangiopathy
Middle Aged
Odds Ratio
Phosphatidylethanolamine N-Methyltransferase - genetics
polymorphism
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
homocysteine
choline
microangiopathy
polymorphism
betaine
diabetes
Online AccessGet full text

Cover

Abstract Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N‐methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications. Methods Between January 2009 and June 2010, 184 diabetic patients and 188 non‐diabetic control subjects were enrolled in the hospital‐based case‐control study. Serum concentrations of betaine and choline were determined by high‐performance liquid chromatography (HPLC)–mass spectrometry. Serum concentrations of homocysteine were assayed using HPLC. PEMT gene mutations were detected by polymerase chain reaction and restriction fragment length polymorphism. Results After adjustment for potential confounders, serum total homocysteine had a significant dose‐dependent positive association, and serum choline had an inverse association with the risks of diabetes and its microangiopathic complications (both p < 0.001). Although serum betaine was not associated with the risk of diabetes, it had a significant inverse association with diabetic microangiopathy. Compared with GG genotype, the CC genotype of PEMT G774C was associated with a decreased risk of diabetes (OR 0.559, 95% CI 0.338, 0.926) and its microangiopathy (OR 0.452, 95% CI 0.218, 0.937). Conclusion The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes. Copyright © 2013 John Wiley & Sons, Ltd.
AbstractList Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N-methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications.BACKGROUNDDiabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N-methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications.Between January 2009 and June 2010, 184 diabetic patients and 188 non-diabetic control subjects were enrolled in the hospital-based case-control study. Serum concentrations of betaine and choline were determined by high-performance liquid chromatography (HPLC)-mass spectrometry. Serum concentrations of homocysteine were assayed using HPLC. PEMT gene mutations were detected by polymerase chain reaction and restriction fragment length polymorphism.METHODSBetween January 2009 and June 2010, 184 diabetic patients and 188 non-diabetic control subjects were enrolled in the hospital-based case-control study. Serum concentrations of betaine and choline were determined by high-performance liquid chromatography (HPLC)-mass spectrometry. Serum concentrations of homocysteine were assayed using HPLC. PEMT gene mutations were detected by polymerase chain reaction and restriction fragment length polymorphism.After adjustment for potential confounders, serum total homocysteine had a significant dose-dependent positive association, and serum choline had an inverse association with the risks of diabetes and its microangiopathic complications (both p < 0.001). Although serum betaine was not associated with the risk of diabetes, it had a significant inverse association with diabetic microangiopathy. Compared with GG genotype, the CC genotype of PEMT G774C was associated with a decreased risk of diabetes (OR 0.559, 95% CI 0.338, 0.926) and its microangiopathy (OR 0.452, 95% CI 0.218, 0.937).RESULTSAfter adjustment for potential confounders, serum total homocysteine had a significant dose-dependent positive association, and serum choline had an inverse association with the risks of diabetes and its microangiopathic complications (both p < 0.001). Although serum betaine was not associated with the risk of diabetes, it had a significant inverse association with diabetic microangiopathy. Compared with GG genotype, the CC genotype of PEMT G774C was associated with a decreased risk of diabetes (OR 0.559, 95% CI 0.338, 0.926) and its microangiopathy (OR 0.452, 95% CI 0.218, 0.937).The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes.CONCLUSIONThe GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes.
Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N-methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications. Methods Between January 2009 and June 2010, 184 diabetic patients and 188 non-diabetic control subjects were enrolled in the hospital-based case-control study. Serum concentrations of betaine and choline were determined by high-performance liquid chromatography (HPLC)-mass spectrometry. Serum concentrations of homocysteine were assayed using HPLC. PEMT gene mutations were detected by polymerase chain reaction and restriction fragment length polymorphism. Results After adjustment for potential confounders, serum total homocysteine had a significant dose-dependent positive association, and serum choline had an inverse association with the risks of diabetes and its microangiopathic complications (both p<0.001). Although serum betaine was not associated with the risk of diabetes, it had a significant inverse association with diabetic microangiopathy. Compared with GG genotype, the CC genotype of PEMT G774C was associated with a decreased risk of diabetes (OR 0.559, 95% CI 0.338, 0.926) and its microangiopathy (OR 0.452, 95% CI 0.218, 0.937). Conclusion The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes. Copyright © 2013 John Wiley & Sons, Ltd. [PUBLICATION ABSTRACT]
Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N‐methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications. Methods Between January 2009 and June 2010, 184 diabetic patients and 188 non‐diabetic control subjects were enrolled in the hospital‐based case‐control study. Serum concentrations of betaine and choline were determined by high‐performance liquid chromatography (HPLC)–mass spectrometry. Serum concentrations of homocysteine were assayed using HPLC. PEMT gene mutations were detected by polymerase chain reaction and restriction fragment length polymorphism. Results After adjustment for potential confounders, serum total homocysteine had a significant dose‐dependent positive association, and serum choline had an inverse association with the risks of diabetes and its microangiopathic complications (both p < 0.001). Although serum betaine was not associated with the risk of diabetes, it had a significant inverse association with diabetic microangiopathy. Compared with GG genotype, the CC genotype of PEMT G774C was associated with a decreased risk of diabetes (OR 0.559, 95% CI 0.338, 0.926) and its microangiopathy (OR 0.452, 95% CI 0.218, 0.937). Conclusion The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes. Copyright © 2013 John Wiley & Sons, Ltd.
Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N-methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications. Between January 2009 and June 2010, 184 diabetic patients and 188 non-diabetic control subjects were enrolled in the hospital-based case-control study. Serum concentrations of betaine and choline were determined by high-performance liquid chromatography (HPLC)-mass spectrometry. Serum concentrations of homocysteine were assayed using HPLC. PEMT gene mutations were detected by polymerase chain reaction and restriction fragment length polymorphism. After adjustment for potential confounders, serum total homocysteine had a significant dose-dependent positive association, and serum choline had an inverse association with the risks of diabetes and its microangiopathic complications (both p < 0.001). Although serum betaine was not associated with the risk of diabetes, it had a significant inverse association with diabetic microangiopathy. Compared with GG genotype, the CC genotype of PEMT G774C was associated with a decreased risk of diabetes (OR 0.559, 95% CI 0.338, 0.926) and its microangiopathy (OR 0.452, 95% CI 0.218, 0.937). The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes.
Author Wei, Jun
Zhou, Jing-ya
Chen, Yu-ming
Zhu, Hui-lian
Ling, Wen-hua
Chen, Yan-ming
Tan, Yao-zong
Chen, Li
Wang, Li-jun
Yang, Yang
Author_xml – sequence: 1
  givenname: Li
  surname: Chen
  fullname: Chen, Li
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 2
  givenname: Yan-ming
  surname: Chen
  fullname: Chen, Yan-ming
  organization: Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
– sequence: 3
  givenname: Li-jun
  surname: Wang
  fullname: Wang, Li-jun
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 4
  givenname: Jun
  surname: Wei
  fullname: Wei, Jun
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 5
  givenname: Yao-zong
  surname: Tan
  fullname: Tan, Yao-zong
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 6
  givenname: Jing-ya
  surname: Zhou
  fullname: Zhou, Jing-ya
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 7
  givenname: Yang
  surname: Yang
  fullname: Yang, Yang
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 8
  givenname: Yu-ming
  surname: Chen
  fullname: Chen, Yu-ming
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 9
  givenname: Wen-hua
  surname: Ling
  fullname: Ling, Wen-hua
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
– sequence: 10
  givenname: Hui-lian
  surname: Zhu
  fullname: Zhu, Hui-lian
  email: Correspondence to: Hui-lian Zhu, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China., zhuhl@mail.sysu.edu.cn
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23794489$$D View this record in MEDLINE/PubMed
BookMark eNp1kc1u1DAUhS1URNuBBS-ALLGBRVon_kmyRENJkVqoRgMsLU9yZ-I2sQfb0ZD36APXYaZdVLC6V1ffObo65xQdGWsAobcpOUsJyc6b3rmzjNHsBTpJeUaSnAty9LTz7Biden9LCKFMsFfoOKN5yVhRnqD7S71pweHW9rYefQBtACvT4M7u4nkFQU0XbWoHygMOLWCn_R22a9zr2lllNtpuVWjHCOG4aDDB450OLW60igbgcQ9dp8Pgca2cG7XZ_PWpKrwBY8O4hcnu5uJ6ias8Z_PX6OVadR7eHOYM_fhysZxfJlffq6_zT1dJTcs0S1JCM86ANGXWNA2vRUrznJCC5oIWBTAAQWlTEOBiBSVwVq9KoAB8zSgXNdAZ-rD33Tr7ewAfZK99HX9VBuzgZcp4mQoiijKi75-ht3ZwJn43UaIsRB7fmaF3B2pY9dDIrdO9cqN8zDsC53sgJue9g7WsdYiZWROc0p1MiZwalVOjcmo0Kj4-Uzya_os9uO90B-P_Qfn5erE4KJK9Qsfq_zwplLuTIqc5l7--VVL8vFlW6XIhCX0A556_3A
CODEN DMRRFM
CitedBy_id crossref_primary_10_1093_cid_ciab147
crossref_primary_10_1093_nutrit_nuv010
crossref_primary_10_1016_j_clnu_2019_10_022
crossref_primary_10_1017_S0007114519001065
crossref_primary_10_14336_AD_2022_1025
crossref_primary_10_15406_ppij_2020_08_00290
crossref_primary_10_1016_j_biopha_2022_112946
crossref_primary_10_1186_s12263_022_00716_9
crossref_primary_10_2174_1381612826666200518112355
crossref_primary_10_3390_nu14163345
crossref_primary_10_1016_j_jnutbio_2015_09_003
crossref_primary_10_1177_15333175221146738
crossref_primary_10_1093_ajcn_nqac255
crossref_primary_10_1016_j_nutres_2018_04_018
crossref_primary_10_1016_j_jdiacomp_2019_06_003
crossref_primary_10_1016_j_tjnut_2024_02_025
crossref_primary_10_3389_fimmu_2018_01070
crossref_primary_10_1515_tjb_2016_0183
crossref_primary_10_1007_s11064_017_2397_3
crossref_primary_10_1159_000507472
crossref_primary_10_1016_j_nut_2016_08_005
Cites_doi 10.1016/j.nut.2012.01.005
10.1111/j.1463-1326.2004.00376.x
10.1210/edrv.20.5.0381
10.1016/0741-8329(96)00030-4
10.1093/ajcn.81.2.440
10.1111/j.1755-3768.2010.02062.x
10.1136/hrt.2006.093971
10.1093/ajcn/83.1.5
10.2337/diacare.24.8.1403
10.2337/diacare.27.2007.S5
10.1016/j.jada.2008.10.046
10.1096/fj.07-101279
10.1093/ajcn/74.6.723
10.1136/bmj.c2181
10.1016/j.jdiacomp.2005.10.005
10.1016/j.jchromb.2007.02.024
10.1016/j.clinbiochem.2010.03.009
10.1161/01.ATV.18.1.133
10.1161/01.ATV.14.3.465
10.1016/j.diabres.2003.10.022
10.1007/s001250050023
10.2174/1389200052997366
10.1093/jn/133.5.1302
10.1056/NEJMoa0908292
10.2337/diacare.23.12.1816
10.1203/00006450-199711000-00004
10.1096/fj.06-5734com
10.1016/S0002-8703(03)00122-4
10.1373/49.2.286
10.1093/jn/133.5.1291
10.1093/ajcn/73.3.613
10.1016/S0021-9258(17)42728-1
10.1210/jc.2006-1471
10.1016/j.diabres.2011.10.029
10.1016/S0021-9150(01)00531-7
10.1161/01.ATV.0000114569.54976.31
10.1038/sj.cdd.4401451
10.1371/journal.pone.0026747
10.1056/NEJM198308253090802
10.1056/NEJM199807233390404
10.1016/S0009-8981(02)00287-5
10.1038/labinvest.3780275
10.1111/j.1365-2362.2004.01319.x
10.1046/j.1365-2893.2000.00206.x
ContentType Journal Article
Copyright Copyright © 2013 John Wiley & Sons, Ltd.
Copyright_xml – notice: Copyright © 2013 John Wiley & Sons, Ltd.
DBID BSCLL
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7TK
H94
K9.
7X8
DOI 10.1002/dmrr.2432
DatabaseName Istex
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Immunology Abstracts
Neurosciences Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Immunology Abstracts
Neurosciences Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
AIDS and Cancer Research Abstracts

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1520-7560
EndPage 617
ExternalDocumentID 3125807521
23794489
10_1002_dmrr_2432
DMRR2432
ark_67375_WNG_6VPTG1TR_0
Genre article
Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: National Natural Science Foundation of China
  funderid: 81273050; 81072302
– fundername: Nutrition Research Foundation of Chinese Nutrition Society
GroupedDBID ---
.3N
.GA
.GJ
.Y3
05W
0R~
10A
1L6
1OC
31~
33P
3SF
3WU
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5RE
5VS
66C
6PF
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AANLZ
AAONW
AASGY
AAWTL
AAXRX
AAZKR
ABCQN
ABCUV
ABIJN
ABJNI
ABLJU
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEIGN
AEIMD
AEQDE
AEUQT
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFPWT
AFZJQ
AHBTC
AHMBA
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ATUGU
AZBYB
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BSCLL
BY8
C45
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
EBD
EBS
EJD
EMOBN
F00
F01
F04
F5P
FEDTE
FUBAC
G-S
G.N
GNP
GODZA
H.X
HBH
HF~
HGLYW
HHY
HHZ
HVGLF
IX1
J0M
JPC
KBYEO
KQQ
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
NF~
NNB
O66
OVD
P2W
P2X
P2Z
P4B
P4D
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RJQFR
ROL
RWI
RX1
RYL
SUPJJ
SV3
TEORI
UB1
V2E
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WJL
WOHZO
WQJ
WRC
WVDHM
WXSBR
XG1
XV2
~IA
~WT
AAHQN
AAIPD
AAMNL
AANHP
AAYCA
ACRPL
ACYXJ
ADNMO
AFWVQ
ALVPJ
AAYXX
AEYWJ
AGHNM
AGQPQ
AGYGG
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7TK
H94
K9.
7X8
ID FETCH-LOGICAL-c3912-103254e0d92ddd5c61377008376388e4ee633d80e56be9e54cb9e3ee5f4356ce3
IEDL.DBID DR2
ISSN 1520-7552
1520-7560
IngestDate Fri Jul 11 01:37:37 EDT 2025
Fri Jul 25 07:06:49 EDT 2025
Thu Apr 03 06:59:49 EDT 2025
Thu Apr 24 23:12:10 EDT 2025
Tue Jul 01 01:51:43 EDT 2025
Wed Jan 22 17:06:04 EST 2025
Wed Oct 30 10:03:51 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords homocysteine
choline
microangiopathy
polymorphism
betaine
diabetes
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
Copyright © 2013 John Wiley & Sons, Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3912-103254e0d92ddd5c61377008376388e4ee633d80e56be9e54cb9e3ee5f4356ce3
Notes istex:917D89E9A26823D6160B66238FF5F5EC83C14526
ArticleID:DMRR2432
ark:/67375/WNG-6VPTG1TR-0
National Natural Science Foundation of China - No. 81273050; No. 81072302
Nutrition Research Foundation of Chinese Nutrition Society
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMID 23794489
PQID 1456986710
PQPubID 866390
PageCount 11
ParticipantIDs proquest_miscellaneous_1459160689
proquest_journals_1456986710
pubmed_primary_23794489
crossref_citationtrail_10_1002_dmrr_2432
crossref_primary_10_1002_dmrr_2432
wiley_primary_10_1002_dmrr_2432_DMRR2432
istex_primary_ark_67375_WNG_6VPTG1TR_0
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-11
November 2013
2013-11-00
2013-Nov
20131101
PublicationDateYYYYMMDD 2013-11-01
PublicationDate_xml – month: 11
  year: 2013
  text: 2013-11
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: Bognor Regis
PublicationTitle Diabetes/metabolism research and reviews
PublicationTitleAlternate Diabetes Metab Res Rev
PublicationYear 2013
Publisher Blackwell Publishing Ltd
Wiley Subscription Services, Inc
Publisher_xml – name: Blackwell Publishing Ltd
– name: Wiley Subscription Services, Inc
References Xu X, Gammon MD, Zeisel SH, et al. Choline metabolism and risk of breast cancer in a population-based study. FASEB J 2008; 22(6): 2045-2052.
Austin RC, Lentz SR, Werstuck GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 2004; 11: S56-S64.
Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr 2003; 133(5): 1291-1295.
Sahin M, Tutuncu NB, Ertugrul D, Tanaci N, Guvener ND. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications 2007; 21: 118-123.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004; 27: S5-S10.
Holm PI, Bleie Ø, Ueland PM, et al. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation. Arterioscler Thromb Vasc Biol 2004; 24(2): 301-307.
Agulló-Ortuño MT, Albaladejo MD, Parra S, et al. Plasmatic homocysteine concentration and its relationship with complications associated to diabetes. Clin Chim Acta 2002; 326(1-2): 105-112.
Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011; 94(3): 311-321.
Meigs JB, Jacques PF, Selhub J, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care 2001; 24(8): 1403-1410.
Surtees R, Bowron A, Leonard J. Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine beta-synthase deficiency: the effect of treatment. Pediatr Res 1997; 42(5): 577-582.
Yang GQ, Lu JM, Zheng H, et al. The relationship between metabolic control and the plasma total homocysteine in type 2 diabetes treated with insulin. Zhonghua Nei Ke Za Zhi 2006; 45: 34-37.
Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996; 13(4): 395-398.
Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 2003; 49(2): 286-294.
Elias AN, Eng S. Homocysteine concentrations in patients with diabetes mellitus-relationship to microvascular and macrovascular disease. Diabetes Obes Metab 2005; 7(2): 117-121.
Melenovsky V, Stulc T, Kozich V, et al. Effect of folic acid on fenofibrate-induced elevation of homocysteine and cysteine. Am Heart J 2003; 146(1): 110.
Russo GT, Di Benedetto A, Giorda C, et al. Correlates of total homocysteine plasma concentration in type 2 diabetes. Eur J Clin Invest 2004; 34(3): 197-204.
Nolin TD, McMenamin ME, Himmelfarb J. Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 852(1-2): 554-561.
Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 2010; 43(9): 732-744.
Fonseca V, Guba SC, Fink LM. Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis. Endocr Rev 1999; 20(5): 738-759.
Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 2006; 83(1): 5-10.
Wang FH, Liang YB, Peng XY, et al. Risk factors for diabetic retinopathy in a rural Chinese population with type 2 diabetes: the Handan eye study. Acta Ophthalmol 2011; 89(4): e336-343.
Xu X, Gammon M, Zeisel S, et al. Choline metabolism and risk of breast cancer in a population-based study. FASEB J 2008; 22: 2045.
Hajer GR, van der Graaf Y, Olijhoek JK, et al. Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome. Heart 2007; 93: 216-220.
Holm PI, Hustad S, Ueland PM, et al. Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate Reductase 677 C-T genotypes and B-vitamin status in a large scale epidemiological study. J Clin Endocrinol Metab 2007; 92(4): 1535-1541.
Sun J, Xu Y, Zhu Y, Lu H. Genetic polymorphism of methylenetetrahydrofolate Reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Res Clin Pract 2004; 64(3): 185-190.
Basuni AA, Butterworth LA, Cooksley G, Locarnini S, Carman WF. An efficient extraction method from blood clots for studies requiring both host and viral DNA. J Viral Hepat 2000; 7(3): 241-243.
Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria: the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983; 309(8): 448-453.
Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc 2009; 109(2): 313-318.
Jacques PF, Bostom AG, Wilson PW, et al. Determinants of plasma total homocysteine concentration in the frammingham offspring cohort. Am J Clin Nutr 2001; 73(3): 613-621.
Hoogeveen EK, Kostense PJ, Beks PJ, et al. Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in noninsulin- dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vasc Biol 1998; 18(1): 133-138.
Rima Obeid, John Jung, Julia Falk, Wolfgang Herrmann, Jürgen Geisel. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie 2012. pii: S0300-9084(12)00447-6.
Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010; 362(12): 1090-1101.
Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339(4): 229-234.
Audelin MC, Genest J Jr. Homocysteine and cardiovascular disease in diabetes mellitus. Atherosclerosis 2001; 159(2): 497-511.
de Jager J, Kooy A, Lehert P, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010; 340: c2181.
Buysschaert M, Dramais AS, Wallemacq PE, Hermans MP. Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance. Diabetes Care 2000; 23(12): 1816-1822.
Kerins DM, Koury MJ, Capdevila A, Rana S, Wagner C. Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. Am J Clin Nutr 2001; 74(6): 723-9.
Finkelstein JD, Martin JJ. Methionine metabolism in mammals. distribution of homocysteine between competing pathways. J Biol Chem 1984; 259(15): 9508-9513.
da Costa KA, Gaffney CE, Fischer LM, Zeisel SH. Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr 2005; 81(2): 440-444.
Durand P, Prost M, Loreau N, Lussier-Cacan S, Blache D. Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest 2001; 81(5): 645-672.
Franken DG, Boers GH, Blom HJ, Trijbels FJ, Kloppenborg PW. Treatment of mild hyperhomocysteinemia in vascular disease patients. Arterioscler Thromb 1994; 14(3): 465-470.
Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab 2005; 6(1): 15-22.
Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition 2012; 28(7-8): e23-26.
Satyanarayana A, Balakrishna N, Pitla S, Reddy PY, Mudili S. Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia. PLoS One 2011; 6: e26747.
Lheto S, Rönnemaa T, Pyörälä K, Laakso M. Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type 2 diabetes. Diabetologia 2000; 43(2): 148-155.
Zeisel SH, Mar MH, Howe JC, Holden JM. Concentrations of choline-containing compounds and betaine in common foods. J Nutr 2003; 133(5): 1302-1307.
da Costa KA, Kozyreva OG, Song J, et al. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J 2006; 20(9): 1336-1344.
2004; 64
2012
2000; 23
2004; 27
1997; 42
2000; 43
2004; 24
2000; 7
1998; 339
2010; 362
2007; 92
2010; 340
1999; 20
2007; 93
2005; 81
1996; 13
2011; 6
2001; 24
2003; 133
2001; 81
2007; 852
2004; 11
1998; 18
2010; 43
2006; 20
2006; 83
2006; 45
2004; 34
1984; 259
2011; 94
2002; 326
2005; 7
1994; 14
2005; 6
2003; 49
2012; 28
2011; 89
2008; 22
2007; 21
2003; 146
2009; 109
1983; 309
2001; 159
2001; 73
2001; 74
e_1_2_7_6_1
e_1_2_7_5_1
e_1_2_7_4_1
e_1_2_7_3_1
e_1_2_7_9_1
Costa KA (e_1_2_7_20_1) 2005; 81
Yang GQ (e_1_2_7_46_1) 2006; 45
e_1_2_7_8_1
e_1_2_7_7_1
e_1_2_7_19_1
e_1_2_7_18_1
e_1_2_7_17_1
e_1_2_7_16_1
e_1_2_7_40_1
e_1_2_7_2_1
e_1_2_7_15_1
e_1_2_7_41_1
e_1_2_7_14_1
e_1_2_7_13_1
e_1_2_7_43_1
e_1_2_7_12_1
e_1_2_7_44_1
e_1_2_7_11_1
e_1_2_7_45_1
e_1_2_7_10_1
e_1_2_7_47_1
e_1_2_7_26_1
e_1_2_7_48_1
e_1_2_7_27_1
e_1_2_7_28_1
e_1_2_7_29_1
e_1_2_7_30_1
e_1_2_7_25_1
e_1_2_7_31_1
e_1_2_7_24_1
e_1_2_7_32_1
e_1_2_7_23_1
e_1_2_7_33_1
e_1_2_7_22_1
e_1_2_7_34_1
e_1_2_7_21_1
e_1_2_7_35_1
e_1_2_7_36_1
e_1_2_7_37_1
e_1_2_7_38_1
e_1_2_7_39_1
Obeid Rima (e_1_2_7_42_1) 2012
References_xml – reference: American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004; 27: S5-S10.
– reference: Hoogeveen EK, Kostense PJ, Beks PJ, et al. Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in noninsulin- dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vasc Biol 1998; 18(1): 133-138.
– reference: Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 2003; 49(2): 286-294.
– reference: Durand P, Prost M, Loreau N, Lussier-Cacan S, Blache D. Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest 2001; 81(5): 645-672.
– reference: Franken DG, Boers GH, Blom HJ, Trijbels FJ, Kloppenborg PW. Treatment of mild hyperhomocysteinemia in vascular disease patients. Arterioscler Thromb 1994; 14(3): 465-470.
– reference: Meigs JB, Jacques PF, Selhub J, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care 2001; 24(8): 1403-1410.
– reference: Kerins DM, Koury MJ, Capdevila A, Rana S, Wagner C. Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. Am J Clin Nutr 2001; 74(6): 723-9.
– reference: Finkelstein JD, Martin JJ. Methionine metabolism in mammals. distribution of homocysteine between competing pathways. J Biol Chem 1984; 259(15): 9508-9513.
– reference: Russo GT, Di Benedetto A, Giorda C, et al. Correlates of total homocysteine plasma concentration in type 2 diabetes. Eur J Clin Invest 2004; 34(3): 197-204.
– reference: Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 2006; 83(1): 5-10.
– reference: Jacques PF, Bostom AG, Wilson PW, et al. Determinants of plasma total homocysteine concentration in the frammingham offspring cohort. Am J Clin Nutr 2001; 73(3): 613-621.
– reference: Fonseca V, Guba SC, Fink LM. Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis. Endocr Rev 1999; 20(5): 738-759.
– reference: Sun J, Xu Y, Zhu Y, Lu H. Genetic polymorphism of methylenetetrahydrofolate Reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Res Clin Pract 2004; 64(3): 185-190.
– reference: Basuni AA, Butterworth LA, Cooksley G, Locarnini S, Carman WF. An efficient extraction method from blood clots for studies requiring both host and viral DNA. J Viral Hepat 2000; 7(3): 241-243.
– reference: Holm PI, Bleie Ø, Ueland PM, et al. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation. Arterioscler Thromb Vasc Biol 2004; 24(2): 301-307.
– reference: Agulló-Ortuño MT, Albaladejo MD, Parra S, et al. Plasmatic homocysteine concentration and its relationship with complications associated to diabetes. Clin Chim Acta 2002; 326(1-2): 105-112.
– reference: Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr 2003; 133(5): 1291-1295.
– reference: Sahin M, Tutuncu NB, Ertugrul D, Tanaci N, Guvener ND. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications 2007; 21: 118-123.
– reference: Xu X, Gammon MD, Zeisel SH, et al. Choline metabolism and risk of breast cancer in a population-based study. FASEB J 2008; 22(6): 2045-2052.
– reference: Satyanarayana A, Balakrishna N, Pitla S, Reddy PY, Mudili S. Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia. PLoS One 2011; 6: e26747.
– reference: da Costa KA, Kozyreva OG, Song J, et al. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J 2006; 20(9): 1336-1344.
– reference: Surtees R, Bowron A, Leonard J. Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine beta-synthase deficiency: the effect of treatment. Pediatr Res 1997; 42(5): 577-582.
– reference: da Costa KA, Gaffney CE, Fischer LM, Zeisel SH. Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr 2005; 81(2): 440-444.
– reference: Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 2010; 43(9): 732-744.
– reference: Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339(4): 229-234.
– reference: de Jager J, Kooy A, Lehert P, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010; 340: c2181.
– reference: Xu X, Gammon M, Zeisel S, et al. Choline metabolism and risk of breast cancer in a population-based study. FASEB J 2008; 22: 2045.
– reference: Lheto S, Rönnemaa T, Pyörälä K, Laakso M. Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type 2 diabetes. Diabetologia 2000; 43(2): 148-155.
– reference: Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010; 362(12): 1090-1101.
– reference: Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab 2005; 6(1): 15-22.
– reference: Rima Obeid, John Jung, Julia Falk, Wolfgang Herrmann, Jürgen Geisel. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie 2012. pii: S0300-9084(12)00447-6.
– reference: Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996; 13(4): 395-398.
– reference: Yang GQ, Lu JM, Zheng H, et al. The relationship between metabolic control and the plasma total homocysteine in type 2 diabetes treated with insulin. Zhonghua Nei Ke Za Zhi 2006; 45: 34-37.
– reference: Holm PI, Hustad S, Ueland PM, et al. Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate Reductase 677 C-T genotypes and B-vitamin status in a large scale epidemiological study. J Clin Endocrinol Metab 2007; 92(4): 1535-1541.
– reference: Audelin MC, Genest J Jr. Homocysteine and cardiovascular disease in diabetes mellitus. Atherosclerosis 2001; 159(2): 497-511.
– reference: Buysschaert M, Dramais AS, Wallemacq PE, Hermans MP. Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance. Diabetes Care 2000; 23(12): 1816-1822.
– reference: Zeisel SH, Mar MH, Howe JC, Holden JM. Concentrations of choline-containing compounds and betaine in common foods. J Nutr 2003; 133(5): 1302-1307.
– reference: Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011; 94(3): 311-321.
– reference: Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition 2012; 28(7-8): e23-26.
– reference: Melenovsky V, Stulc T, Kozich V, et al. Effect of folic acid on fenofibrate-induced elevation of homocysteine and cysteine. Am Heart J 2003; 146(1): 110.
– reference: Hajer GR, van der Graaf Y, Olijhoek JK, et al. Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome. Heart 2007; 93: 216-220.
– reference: Elias AN, Eng S. Homocysteine concentrations in patients with diabetes mellitus-relationship to microvascular and macrovascular disease. Diabetes Obes Metab 2005; 7(2): 117-121.
– reference: Nolin TD, McMenamin ME, Himmelfarb J. Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 852(1-2): 554-561.
– reference: Austin RC, Lentz SR, Werstuck GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 2004; 11: S56-S64.
– reference: Wang FH, Liang YB, Peng XY, et al. Risk factors for diabetic retinopathy in a rural Chinese population with type 2 diabetes: the Handan eye study. Acta Ophthalmol 2011; 89(4): e336-343.
– reference: Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria: the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983; 309(8): 448-453.
– reference: Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc 2009; 109(2): 313-318.
– volume: 94
  start-page: 311
  issue: 3
  year: 2011
  end-page: 321
  article-title: IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030
  publication-title: Diabetes Res Clin Pract
– volume: 852
  start-page: 554
  issue: 1–2
  year: 2007
  end-page: 561
  article-title: Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high‐performance liquid chromatography: application to studies of oxidative stress
  publication-title: J Chromatogr B Analyt Technol Biomed Life Sci
– volume: 339
  start-page: 229
  issue: 4
  year: 1998
  end-page: 234
  article-title: Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
  publication-title: N Engl J Med
– volume: 42
  start-page: 577
  issue: 5
  year: 1997
  end-page: 582
  article-title: Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine beta‐synthase deficiency: the effect of treatment
  publication-title: Pediatr Res
– volume: 133
  start-page: 1291
  issue: 5
  year: 2003
  end-page: 1295
  article-title: Betaine supplementation lowers plasma homocysteine in healthy men and women
  publication-title: J Nutr
– volume: 64
  start-page: 185
  issue: 3
  year: 2004
  end-page: 190
  article-title: Genetic polymorphism of methylenetetrahydrofolate Reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients
  publication-title: Diabetes Res Clin Pract
– volume: 43
  start-page: 732
  issue: 9
  year: 2010
  end-page: 744
  article-title: The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism
  publication-title: Clin Biochem
– volume: 18
  start-page: 133
  issue: 1
  year: 1998
  end-page: 138
  article-title: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in noninsulin‐ dependent diabetes mellitus: a population‐based study
  publication-title: Arterioscler Thromb Vasc Biol
– volume: 49
  start-page: 286
  issue: 2
  year: 2003
  end-page: 294
  article-title: Determination of choline, betaine, and dimethylglycine in plasma by a high‐throughput method based on normal‐phase chromatography‐tandem mass spectrometry
  publication-title: Clin Chem
– volume: 92
  start-page: 1535
  issue: 4
  year: 2007
  end-page: 1541
  article-title: Modulation of the homocysteine‐betaine relationship by methylenetetrahydrofolate Reductase 677 C–T genotypes and B‐vitamin status in a large scale epidemiological study
  publication-title: J Clin Endocrinol Metab
– volume: 74
  start-page: 723
  issue: 6
  year: 2001
  end-page: 9
  article-title: Plasma S‐adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine
  publication-title: Am J Clin Nutr
– volume: 45
  start-page: 34
  year: 2006
  end-page: 37
  article-title: The relationship between metabolic control and the plasma total homocysteine in type 2 diabetes treated with insulin
  publication-title: Zhonghua Nei Ke Za Zhi
– volume: 362
  start-page: 1090
  issue: 12
  year: 2010
  end-page: 1101
  article-title: Prevalence of diabetes among men and women in China
  publication-title: N Engl J Med
– volume: 11
  start-page: S56
  year: 2004
  end-page: S64
  article-title: Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
  publication-title: Cell Death Differ
– volume: 13
  start-page: 395
  issue: 4
  year: 1996
  end-page: 398
  article-title: Betaine, ethanol, and the liver: a review
  publication-title: Alcohol
– volume: 24
  start-page: 1403
  issue: 8
  year: 2001
  end-page: 1410
  article-title: Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study
  publication-title: Diabetes Care
– volume: 340
  start-page: c2181
  year: 2010
  article-title: Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B‐12 deficiency: randomised placebo controlled trial
  publication-title: BMJ
– volume: 81
  start-page: 440
  issue: 2
  year: 2005
  end-page: 444
  article-title: Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load
  publication-title: Am J Clin Nutr
– volume: 24
  start-page: 301
  issue: 2
  year: 2004
  end-page: 307
  article-title: Betaine as a determinant of postmethionine load total plasma homocysteine before and after B‐vitamin supplementation
  publication-title: Arterioscler Thromb Vasc Biol
– volume: 22
  start-page: 2045
  issue: 6
  year: 2008
  end-page: 2052
  article-title: Choline metabolism and risk of breast cancer in a population‐based study
  publication-title: FASEB J
– volume: 43
  start-page: 148
  issue: 2
  year: 2000
  end-page: 155
  article-title: Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type 2 diabetes
  publication-title: Diabetologia
– volume: 14
  start-page: 465
  issue: 3
  year: 1994
  end-page: 470
  article-title: Treatment of mild hyperhomocysteinemia in vascular disease patients
  publication-title: Arterioscler Thromb
– volume: 83
  start-page: 5
  issue: 1
  year: 2006
  end-page: 10
  article-title: Is it time to reevaluate methyl balance in humans?
  publication-title: Am J Clin Nutr
– volume: 6
  start-page: 15
  issue: 1
  year: 2005
  end-page: 22
  article-title: Effects of betaine intake on plasma homocysteine concentrations and consequences for health
  publication-title: Curr Drug Metab
– volume: 309
  start-page: 448
  issue: 8
  year: 1983
  end-page: 453
  article-title: Homocystinuria: the effects of betaine in the treatment of patients not responsive to pyridoxine
  publication-title: N Engl J Med
– volume: 89
  start-page: e336
  issue: 4
  year: 2011
  end-page: 343
  article-title: Risk factors for diabetic retinopathy in a rural Chinese population with type 2 diabetes: the Handan eye study
  publication-title: Acta Ophthalmol
– volume: 81
  start-page: 645
  issue: 5
  year: 2001
  end-page: 672
  article-title: Impaired homocysteine metabolism and atherothrombotic disease
  publication-title: Lab Invest
– volume: 146
  start-page: 110
  issue: 1
  year: 2003
  article-title: Effect of folic acid on fenofibrate‐induced elevation of homocysteine and cysteine
  publication-title: Am Heart J
– volume: 20
  start-page: 1336
  issue: 9
  year: 2006
  end-page: 1344
  article-title: Common genetic polymorphisms affect the human requirement for the nutrient choline
  publication-title: FASEB J
– volume: 22
  start-page: 2045
  year: 2008
  article-title: Choline metabolism and risk of breast cancer in a population‐based study
  publication-title: FASEB J
– year: 2012
  article-title: Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
  publication-title: Biochimie
– volume: 93
  start-page: 216
  year: 2007
  end-page: 220
  article-title: Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome
  publication-title: Heart
– volume: 259
  start-page: 9508
  issue: 15
  year: 1984
  end-page: 9513
  article-title: Methionine metabolism in mammals. distribution of homocysteine between competing pathways
  publication-title: J Biol Chem
– volume: 326
  start-page: 105
  issue: 1–2
  year: 2002
  end-page: 112
  article-title: Plasmatic homocysteine concentration and its relationship with complications associated to diabetes
  publication-title: Clin Chim Acta
– volume: 27
  start-page: S5
  year: 2004
  end-page: S10
  article-title: Diagnosis and classification of diabetes mellitus
  publication-title: Diabetes Care
– volume: 6
  start-page: e26747
  year: 2011
  article-title: Status of B‐vitamins and homocysteine in diabetic retinopathy: association with vitamin‐B12 deficiency and hyperhomocysteinemia
  publication-title: PLoS One
– volume: 34
  start-page: 197
  issue: 3
  year: 2004
  end-page: 204
  article-title: Correlates of total homocysteine plasma concentration in type 2 diabetes
  publication-title: Eur J Clin Invest
– volume: 7
  start-page: 117
  issue: 2
  year: 2005
  end-page: 121
  article-title: Homocysteine concentrations in patients with diabetes mellitus—relationship to microvascular and macrovascular disease
  publication-title: Diabetes Obes Metab
– volume: 109
  start-page: 313
  issue: 2
  year: 2009
  end-page: 318
  article-title: Genetic variants in phosphatidylethanolamine N‐methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted
  publication-title: J Am Diet Assoc
– volume: 28
  start-page: e23
  issue: 7‐8
  year: 2012
  end-page: 26
  article-title: Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes
  publication-title: Nutrition
– volume: 159
  start-page: 497
  issue: 2
  year: 2001
  end-page: 511
  article-title: Homocysteine and cardiovascular disease in diabetes mellitus
  publication-title: Atherosclerosis
– volume: 21
  start-page: 118
  year: 2007
  end-page: 123
  article-title: Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus
  publication-title: J Diabetes Complications
– volume: 20
  start-page: 738
  issue: 5
  year: 1999
  end-page: 759
  article-title: Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis
  publication-title: Endocr Rev
– volume: 73
  start-page: 613
  issue: 3
  year: 2001
  end-page: 621
  article-title: Determinants of plasma total homocysteine concentration in the frammingham offspring cohort
  publication-title: Am J Clin Nutr
– volume: 7
  start-page: 241
  issue: 3
  year: 2000
  end-page: 243
  article-title: An efficient extraction method from blood clots for studies requiring both host and viral DNA
  publication-title: J Viral Hepat
– volume: 23
  start-page: 1816
  issue: 12
  year: 2000
  end-page: 1822
  article-title: Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance
  publication-title: Diabetes Care
– volume: 133
  start-page: 1302
  issue: 5
  year: 2003
  end-page: 1307
  article-title: Concentrations of choline‐containing compounds and betaine in common foods
  publication-title: J Nutr
– ident: e_1_2_7_4_1
  doi: 10.1016/j.nut.2012.01.005
– ident: e_1_2_7_11_1
  doi: 10.1111/j.1463-1326.2004.00376.x
– ident: e_1_2_7_7_1
  doi: 10.1210/edrv.20.5.0381
– ident: e_1_2_7_19_1
  doi: 10.1016/0741-8329(96)00030-4
– volume: 81
  start-page: 440
  issue: 2
  year: 2005
  ident: e_1_2_7_20_1
  article-title: Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn.81.2.440
– ident: e_1_2_7_28_1
  doi: 10.1111/j.1755-3768.2010.02062.x
– ident: e_1_2_7_35_1
  doi: 10.1136/hrt.2006.093971
– ident: e_1_2_7_25_1
  doi: 10.1093/ajcn/83.1.5
– ident: e_1_2_7_34_1
  doi: 10.2337/diacare.24.8.1403
– ident: e_1_2_7_27_1
  doi: 10.2337/diacare.27.2007.S5
– ident: e_1_2_7_24_1
  doi: 10.1016/j.jada.2008.10.046
– ident: e_1_2_7_33_1
  doi: 10.1096/fj.07-101279
– ident: e_1_2_7_43_1
  doi: 10.1093/ajcn/74.6.723
– ident: e_1_2_7_47_1
  doi: 10.1136/bmj.c2181
– ident: e_1_2_7_45_1
  doi: 10.1016/j.jdiacomp.2005.10.005
– volume: 45
  start-page: 34
  year: 2006
  ident: e_1_2_7_46_1
  article-title: The relationship between metabolic control and the plasma total homocysteine in type 2 diabetes treated with insulin
  publication-title: Zhonghua Nei Ke Za Zhi
– ident: e_1_2_7_30_1
  doi: 10.1016/j.jchromb.2007.02.024
– ident: e_1_2_7_41_1
  doi: 10.1016/j.clinbiochem.2010.03.009
– ident: e_1_2_7_12_1
  doi: 10.1161/01.ATV.18.1.133
– ident: e_1_2_7_40_1
  doi: 10.1161/01.ATV.14.3.465
– ident: e_1_2_7_29_1
  doi: 10.1016/j.diabres.2003.10.022
– year: 2012
  ident: e_1_2_7_42_1
  article-title: Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
  publication-title: Biochimie
– ident: e_1_2_7_5_1
  doi: 10.1007/s001250050023
– ident: e_1_2_7_23_1
  doi: 10.2174/1389200052997366
– ident: e_1_2_7_48_1
  doi: 10.1093/jn/133.5.1302
– ident: e_1_2_7_3_1
  doi: 10.1056/NEJMoa0908292
– ident: e_1_2_7_9_1
  doi: 10.2337/diacare.23.12.1816
– ident: e_1_2_7_38_1
  doi: 10.1203/00006450-199711000-00004
– ident: e_1_2_7_26_1
  doi: 10.1096/fj.06-5734com
– ident: e_1_2_7_17_1
  doi: 10.1016/S0002-8703(03)00122-4
– ident: e_1_2_7_31_1
  doi: 10.1373/49.2.286
– ident: e_1_2_7_18_1
  doi: 10.1093/jn/133.5.1291
– ident: e_1_2_7_14_1
  doi: 10.1093/ajcn/73.3.613
– ident: e_1_2_7_37_1
  doi: 10.1016/S0021-9258(17)42728-1
– ident: e_1_2_7_22_1
  doi: 10.1210/jc.2006-1471
– ident: e_1_2_7_2_1
  doi: 10.1016/j.diabres.2011.10.029
– ident: e_1_2_7_44_1
  doi: 10.1096/fj.07-101279
– ident: e_1_2_7_8_1
  doi: 10.1016/S0021-9150(01)00531-7
– ident: e_1_2_7_21_1
  doi: 10.1161/01.ATV.0000114569.54976.31
– ident: e_1_2_7_36_1
  doi: 10.1038/sj.cdd.4401451
– ident: e_1_2_7_10_1
  doi: 10.1371/journal.pone.0026747
– ident: e_1_2_7_39_1
  doi: 10.1056/NEJM198308253090802
– ident: e_1_2_7_6_1
  doi: 10.1056/NEJM199807233390404
– ident: e_1_2_7_13_1
  doi: 10.1016/S0009-8981(02)00287-5
– ident: e_1_2_7_16_1
  doi: 10.1038/labinvest.3780275
– ident: e_1_2_7_15_1
  doi: 10.1111/j.1365-2362.2004.01319.x
– ident: e_1_2_7_32_1
  doi: 10.1046/j.1365-2893.2000.00206.x
SSID ssj0003464
Score 2.1820152
Snippet Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl...
Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and...
Background Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl...
SourceID proquest
pubmed
crossref
wiley
istex
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 607
SubjectTerms Adult
Aged
Aged, 80 and over
betaine
Betaine - blood
Biomarkers - blood
Case-Control Studies
choline
diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetic Angiopathies - genetics
Female
Genotype
homocysteine
Homocysteine - blood
Humans
Male
microangiopathy
Middle Aged
Odds Ratio
Phosphatidylethanolamine N-Methyltransferase - genetics
polymorphism
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Title Higher homocysteine and lower betaine increase the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C
URI https://api.istex.fr/ark:/67375/WNG-6VPTG1TR-0/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdmrr.2432
https://www.ncbi.nlm.nih.gov/pubmed/23794489
https://www.proquest.com/docview/1456986710
https://www.proquest.com/docview/1459160689
Volume 29
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1baxQxFA6lgvji_bJaJYpIX2Y7m1sTfJLaThG2lGWrfRDCTHJWS7szMrML6u_wB5uTuZRKBfFtSM7MZDInJ19OTr5DyGteKCe90wkILROhJy7R3vPEaFMIX4TSeEhseqQOT8SHU3m6Qd72Z2FafojB4YYjI9prHOB50exckob6ZV2PmeBofzFWCwHR7JI6iotIHRWmpzTZlZL1rEIp2xnuvDIX3cBu_X4d0LyKW-PEc3CHfO6b3MabnI_Xq2Lsfv7B5vif33SX3O4AKX3XatA9sgHlfXJz2m25PyC_2kgQ-rVaVg5pn0MpzUtPLzC_Gi0wBDWUnJUIPxugAVBSjFen1YIuMdovL7-cVZj4-EcQoh2Pa0PRAUx7zy9dIi_oat1Ql9c1nryKz8kyihyy6CbGxx3vT-c0C0hy7yE5Odif7x0mXSqHxHEzYQnS9kkBqTfMey-dQqJDhH_BvGkNAkBx7nUKUhVgQApXGOAAchHgnHLAH5HNsirhCaEKM5FLtWCQgggLsjw3bMGRVxG0Y8yMyHb_U63reM4x3caFbRmamcVettjLI_JqEP3WkntcJ_QmasYgkdfnGA23K-2no8yqj8fzbDKf2XREtnrVsZ0haMLKSiqDHIKh-uVQHYYw7svkJVTrKBNAeqp0aPvjVuWGlzEeDKbAmu2oOH9vp30_nc3w4um_iz4jtxim94hnK7fI5qpew_MAslbFiziafgPiBCMN
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9QwELaqVgJeuI-FAgYh1Jdss77qSLygHlmgWVWrFPqCosSehardBGV3JeB38IPxOEdVVCTEW2RPEscZjz-Px98Q8ooXykhrdABCy0DokQm0tTyIdFQIW7hSf0gsmajxsXh_Ik_WyJvuLEzDD9E73HBkeHuNAxwd0tsXrKF2XtdDJrgzwBuY0RuZ8_emF-RRXHjyKDdBhcGOlKzjFQrZdn_rpdloAzv2-1VQ8zJy9VPPwS3yuWt0E3FyNlwti6H5-Qef4_9-1W1ys8Wk9G2jRHfIGpR3ybWk3XW_R341wSD0azWvDDI_u1Kal5aeY4o1WmAUqis5LRGBLoA6TEkxZJ1WMzrHgL-8_HJaYe7jH06ItlSuC4o-YNo5f-kcqUGXqwU1eV3j4Sv_nDimSCOLnmJ83NF-ktLYgcnd--T4YD_dHQdtNofA8GjEAmTukwJCGzFrrTQKuQ4RAToLpzUIAMW51SFIVUAEUpgiAg4gZw7RKQP8AVkvqxIeEaowGblUMwYhCLcmy_OIzThSK4I2jEUDstX91cy0VOeYceM8a0iaWYa9nGEvD8jLXvRbw-9xldBrrxq9RF6fYUDcjsw-TeJMfTxK41E6zcIB2ex0J2ttwcItrqSKkEbQVb_oq90oxq2ZvIRq5WUcTg-Vdm1_2Ohc_zLGnc0UWLPlNefv7cz2kukULx7_u-hzcn2cJofZ4bvJhyfkBsNsH_6o5SZZX9YreOow17J45ofWb_mnJyk
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLamTZp44X4pDDAIob2kS32bLZ7QumZcWlVVB3tAshLbgWlrMqWtBPwOfjA-zmUaGhLiLbJPEsc5Pv58fPwdhF7RTBhujYwckzxicmAiaS2NlFQZs5kvDYfExhNxdMzen_CTDfSmPQtT80N0DjcYGcFewwC_sPneJWmoXVRVnzDq7e8WE7GCvA3D2SV3FGWBO8rPT3G0zzlpaYVistfdemUy2oJ-_X4d0rwKXMPMM7qFvrRtrgNOzvrrVdY3P_-gc_zPj7qNbjaIFL-tVegO2nDFXbQ9bvbc76FfdSgI_lYuSgO8z74Up4XF55BgDWcQg-pLTgvAn0uHPaLEELCOyxwvINwvLb6elpD5-IcXwg2R6xKDBxi3rl-8AGLQ1XqJTVpVcPQqPCdJMJDIgp8YHjc9HM9x4qHkwX10PDqcHxxFTS6HyFA1IBHw9nHmYquItZYbAUyHgP-8fZPSMecEpVbGjovMKceZyZSjzvHc4zlhHH2ANouycI8QFpCKnIucuNgxvyJLU0VyCsSKThpCVA_ttj9Vm4boHPJtnOuaoplo6GUNvdxDLzvRi5rd4zqh10EzOom0OoNwuH2uP08SLT5N58lgPtNxD-20qqMbS7D0SysuFJAI-uoXXbUfw7AxkxauXAcZj9JjIX3bH9Yq172MUG8xGdTsBsX5ezv1cDybwcXjfxd9jranw5H--G7y4Qm6QSDVRzhnuYM2V9XaPfWAa5U9CwPrN2pdJdg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Higher+homocysteine+and+lower+betaine+increase+the+risk+of+microangiopathy+in+patients+with+diabetes+mellitus+carrying+the+GG+genotype+of+PEMT+G774C&rft.jtitle=Diabetes%2Fmetabolism+research+and+reviews&rft.au=Chen%2C+Li&rft.au=Chen%2C+Yan-ming&rft.au=Wang%2C+Li-jun&rft.au=Wei%2C+Jun&rft.date=2013-11-01&rft.eissn=1520-7560&rft.volume=29&rft.issue=8&rft.spage=607&rft_id=info:doi/10.1002%2Fdmrr.2432&rft_id=info%3Apmid%2F23794489&rft.externalDocID=23794489
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1520-7552&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1520-7552&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1520-7552&client=summon