ANTIMETABOLITES PRODUCED BY MICROORGANISMS. XV SYNTHESIS OF 2-METHYL-L-ARGININE, 2-METHYL-L-ORNITHINE AND THEIR ENANTIOMERS

• Published in: Journal of antibiotics Vol. 29; no. 3; pp. 221 - 226
• Main Authors: MAEHR, H., YARMCHUK, L., LEACH, M.
• Format: Journal Article
• Language: English
• Published: Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1976
• Subjects: Arginine - analogs & derivatives; Arginine - chemical synthesis; Chemical Phenomena; Chemistry; Imidazoles; Ornithine - analogs & derivatives; Ornithine - chemical synthesis

5-(3-Azidopropyl)-5-methyl-2, 4-imidazolidinedione was prepared either from 5-(3-chloropropyl)-5-methyl-2, 4-imidazolidinedione or 5-methyl-5-{3-[(4-methylphenyl)sulfonyloxy]-propyl}-2, 4-imidazolidinedione and hydrogenolyzed to the corresponding amine which, after carbamimidoylation, afforded 2-met...