Voluntary Activity Wheel Running Improves Hyperammonaemia‐Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 16; no. 4; pp. e70031 - n/a
• Main Authors: Bellar, Annette, Kumar, Avinash, Chandramohan, Khaviyaa, Mishra, Saurabh, Alsabbagh‐Alchirazi, Muaz, Astafev, Artem, Kannan, Pugazhendhi, Attaway, Amy, Kondratov, Roman, Jaramillo, Thomas, Mishra, Lopa, Kasumov, Takhar, Welch, Nicole, Dasarathy, Srinivasan
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2025; John Wiley and Sons Inc; Wiley
• Subjects: Ammonia; Animals; Body composition; Chronic illnesses; Disease Models, Animal; Exercise; Fatigue; Fitness equipment; hyperammonaemia; Hyperammonemia - metabolism; Kinases; Liver cirrhosis; Male; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; mitochondrial function; Muscle, Skeletal - metabolism; Musculoskeletal system; Original; Physical Conditioning, Animal; Physical fitness; Protein synthesis; Proteins; Running; Sarcopenia; voluntary wheel running; voluntary wheel running; exercise; mitochondrial function; hyperammonaemia; sarcopenia

ABSTRACT Aim Voluntary exercise improves clinical outcomes in healthy subjects, but increased muscle ammoniagenesis may limit beneficial responses during hyperammonaemia in chronic diseases. Responses to 4‐weeks voluntary wheel running (VWR) were compared with usual activity (UA) to determine if hyp...