Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

• Published in: Diabetes, obesity & metabolism Vol. 15; no. 5; pp. 427 - 431
• Main Authors: Pitocco, D., Zaccardi, F., Tarzia, P., Milo, M., Scavone, G., Rizzo, P., Pagliaccia, F., Nerla, R., Di Franco, A., Manto, A., Rocca, B., Lanza, G. A., Crea, F., Ghirlanda, G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2013; Wiley Subscription Services, Inc
• Subjects: Adult; Biomarkers - blood; Biomarkers - metabolism; Blood Glucose - metabolism; Brachial Artery - drug effects; Brachial Artery - physiopathology; cardiovascular disease; Confidence intervals; Diabetes; diabetes complications; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - physiopathology; Dinoprost - metabolism; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Glycated Hemoglobin A - metabolism; Humans; Hypoglycemic Agents - therapeutic use; Insulin - therapeutic use; macrovascular disease; Male; metformin; Metformin - therapeutic use; Oxidative stress; Oxidative Stress - drug effects; Pilot Projects; Treatment Outcome; type 1 diabetes; Vasodilation - drug effects

Aims Several studies have investigated the effects of metformin treatment in patients with type 1 diabetes mellitus (T1DM). No study has hitherto examined its effects on endothelial function in these patients. In this study we sought to evaluate the effect of metformin on endothelial function in typ...