Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron‐induced hepatotoxicity

• Published in: Hepatology (Baltimore, Md.) Vol. 76; no. 2; pp. 387 - 403
• Main Authors: Xiong, Hui, Zhang, Chunze, Han, Lifeng, Xu, Tong, Saeed, Khawar, Han, Jing, Liu, Jing, Klaassen, Curtis D., Gonzalez, Frank J., Lu, Yuanfu, Zhang, Youcai
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.08.2022
• Subjects: Agonists; Ammonium; Bile; Bile acids; Blood diseases; Dextran; Diet; Fatty liver; Ferrous sulfate; Fibroblast growth factors; Hepatocytes; Hepatology; Hepatotoxicity; Homeostasis; Iron; Iron deficiency; Liver diseases; Metabolic syndrome; Nutrient deficiency; Oral administration; Regulatory proteins; Serum levels; Steatosis; Thalassemia

Background and Aims Iron overload (IO) is a frequent finding in the general population. As the major iron storage site, the liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. We aimed to determine whether FXR play...