MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5

• Published in: The FASEB journal Vol. 39; no. 11; pp. e70690 - n/a
• Main Authors: Wang, Zhenya, Wei, Tong‐You Wade, Chen, Jo‐Mei Maureen, Zhang, Ke, Zhang, Yiwei, Shi, Huiting, Su, Hsiang‐Chun, Hsieh, I‐Shan, Yu, Chang‐Tze Ricky, Zhao, Guo‐Jun
• Format: Journal Article
• Language: English
• Published: United States 15.06.2025
• Subjects: Animals; Apoptosis; cardiomyocyte death; Down-Regulation; Male; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; miR‐100‐5p; myocardial I/R injury; Myocardial Infarction - genetics; Myocardial Infarction - metabolism; Myocardial Reperfusion Injury - genetics; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Phosphatidylinositol 3-Kinases - metabolism; PI3K‐AKT pathway; PRMT5; Protein-Arginine N-Methyltransferases - genetics; Protein-Arginine N-Methyltransferases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; PTEN; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Signal Transduction; PTEN; PRMT5; miR‐100‐5p; myocardial I/R injury; cardiomyocyte death; PI3K‐AKT pathway

ABSTRACT Acute myocardial infarction (AMI) rates are rising due to the increasing prevalence of cardiac metabolic disorders, particularly diabetes mellitus (DM). While revascularization procedures such as coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) restore blo...