Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells

• Published in: Cellular and molecular neurobiology Vol. 39; no. 3; pp. 331 - 340
• Main Authors: Galán-Ganga, Marcos, García-Yagüe, Ángel J., Lastres-Becker, Isabel
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2019; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brief Communication; Cell Biology; Chemokine CX3CL1 - pharmacology; Chemokines; CX3C Chemokine Receptor 1 - metabolism; CX3CR1 protein; Extracellular signal-regulated kinase; Fractalkine; IL-1β; Inflammation; Inflammation Mediators - metabolism; Kinases; Lck protein; MAP kinase; Mice, Knockout; Microglia; Microglia - drug effects; Microglia - metabolism; Microglial cells; Models, Biological; Msk1 protein; Neurobiology; Neurosciences; NF-kappa B - metabolism; NF-κB protein; Phosphorylation - drug effects; Proteomes; Ribosomal Protein S6 Kinases, 90-kDa - metabolism; Signal transduction; Signal Transduction - drug effects; Transcription Factor RelA - metabolism; Tumor necrosis factor-α; Tyrosine; CX3CR1; Neuroinflammation; Nrf2; P65; NF-kB; Microglia

Microglial cells are essential mediators of neuroinflammatory processes involved in several pathologies. Moreover, the chemokine fractalkine (CX3CL1) is essential in the crosstalk between neurons and microglia. However, the exact roles of CX3CL1, CX3CL1 receptor (CX3CR1) and microglia signalling are...