Ciprofloxacin eye drops-induced subtherapeutic serum phenytoin levels resulting in breakthrough seizures

• Published in: Singapore medical journal Vol. 55; no. 7; pp. e114 - e115
• Main Authors: Malladi, Srinivasa Sastry, Liew, Emily Kai Suen, Ng, Xiao Ting, Tan, Rita Kheng Siew
• Format: Journal Article
• Language: English
• Published: Singapore Singapore Medical Association 01.07.2014
• Subjects: Administration, Oral; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Case Report; Ciprofloxacin - administration & dosage; Ciprofloxacin - adverse effects; Drug Interactions; Epilepsy, Temporal Lobe - drug therapy; Female; Hospitalization; Humans; Ophthalmic Solutions - adverse effects; Phenytoin - blood; Psychotic Disorders - drug therapy; Seizures - chemically induced

An 81-year-old woman with a history of temporal lobe epilepsy-induced psychotic episodes was initially admitted to a general hospital where she was started on a course of oral antibiotics for community-acquired pneumonia, and ciprofloxacin eye drops to treat nasolacrimal duct obstruction. After one...