Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections - Goss, Christopher H; Kaneko, Yukihiro; Khuu, Lisa; Anderson, Gail D; Ravishankar, Sumedha; Aitken, Moira L; Lechtzin, Noah; Zhou, Guolin; Czyz, Daniel M; McLean, Kathryn; Olakanmi, Oyebode; Shuman, Howard A; et al. (Science translational medicine, 2018)
Keywords: Adolescent; Adult; Animals; Anti-Bacterial Agents - pharmacology; Bacterial Proteins - metabolism; Cystic Fibrosis - microbiology; Cystic Fibrosis - physiopathology; DNA Transposable Elements - genetics; Drug Resistance, Bacterial - drug effects; Drug Synergism; Gallium - pharmacokinetics; Gallium - pharmacology; Gallium - therapeutic use; Genes, Bacterial; Humans; Iron - metabolism; Lung - drug effects; Lung - microbiology; Lung - physiopathology; Macrophages - drug effects; Macrophages - microbiology; Mice, Inbred C57BL; Microbial Viability - drug effects; Middle Aged; Mutagenesis; Mutation - genetics; Oxidants - toxicity; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - growth & development; Pseudomonas aeruginosa - metabolism; Pseudomonas Infections - microbiology; Pseudomonas Infections - physiopathology; Respiratory Tract Infections - microbiology; Respiratory Tract Infections - physiopathology; Sputum - microbiology; Young Adult