A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K + Channels in Rabbit Ventricular Myocytes
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K(+) current (I(K)) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent E...
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| Published in | The Korean journal of physiology & pharmacology Vol. 14; no. 3; pp. 119 - 125 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Physiological Society and The Korean Society of Pharmacology
01.06.2010
대한약리학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-4512 2093-3827 |
| DOI | 10.4196/kjpp.2010.14.3.119 |
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| Abstract | We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K(+) current (I(K)) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC(50) value of 56.1+/-5.5 microg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating I(K) without significantly altering the resting membrane potential (IC(50) value of APD(50): 54.80+/-2.24, IC(50) value of APD(90): 57.45+/-3.47 microg/ml). Based on the results, all experiments were performed with 50 microg/ml of AIP1. Pre-treatment with the rapidly activating delayed rectifier K(+) current (I(Kr)) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier K(+) current (I(Ks)) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating I(Kr) but not I(Ks). These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome. |
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| AbstractList | We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K(+) current (I(K)) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC(50) value of 56.1+/-5.5 microg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating I(K) without significantly altering the resting membrane potential (IC(50) value of APD(50): 54.80+/-2.24, IC(50) value of APD(90): 57.45+/-3.47 microg/ml). Based on the results, all experiments were performed with 50 microg/ml of AIP1. Pre-treatment with the rapidly activating delayed rectifier K(+) current (I(Kr)) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier K(+) current (I(Ks)) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating I(Kr) but not I(Ks). These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome. We investigated the effects of a hot-water extract of Artemisia iwayomogi , a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K + current ( I K ) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC 50 value of 56.1±5.5 µg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating I K without significantly altering the resting membrane potential (IC 50 value of APD 50 : 54.80±2.24, IC 50 value of APD 90 : 57.45±3.47 µg/ml). Based on the results, all experiments were performed with 50 µg/ml of AIP1. Pre-treatment with the rapidly activating delayed rectifier K + current ( I Kr ) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier K + current ( I Ks ) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating I Kr but not I Ks . These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome. We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K＋ current (IK) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC50 value of 56.1±5.5μg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating IK without significantly altering the resting membrane potential (IC50 value of APD50: 54.80±2.24, IC50 value of APD90: 57.45±3.47μg/ml). Based on the results, all experiments were performed with 50μg/ml of AIP1. Pre-treatment with the rapidly activating delayed rectifier K＋ current (IKr) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier K＋ current (IKs) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating IKr but not IKs. These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome. KCI Citation Count: 3 |
| Author | Choi, Seong Woo Kim, Nari Choi, Tae-Hoon Hong, Da Hye Han, Jin Ko, Eun A Jo, Su-Hyun Park, Won Sun Son, Youn Kyoung Youn, Hyun Joo |
| AuthorAffiliation | 1 Department of Physiology, Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon 200-701, Korea 2 National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea 3 Department of Sport and Leisure Studies, Andong Science College, Andong 760-709, Korea 4 Department of Microbiology and School of Biotechnology & Biomedical Science, Inje University, Gimhae 621-749, Korea |
| AuthorAffiliation_xml | – name: 2 National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea – name: 1 Department of Physiology, Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon 200-701, Korea – name: 4 Department of Microbiology and School of Biotechnology & Biomedical Science, Inje University, Gimhae 621-749, Korea – name: 3 Department of Sport and Leisure Studies, Andong Science College, Andong 760-709, Korea |
| Author_xml | – sequence: 1 givenname: Won Sun surname: Park fullname: Park, Won Sun organization: Department of Physiology, Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon 200-701, Korea – sequence: 2 givenname: Youn Kyoung surname: Son fullname: Son, Youn Kyoung organization: Department of Physiology, Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon 200-701, Korea – sequence: 3 givenname: Eun A surname: Ko fullname: Ko, Eun A organization: National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea – sequence: 4 givenname: Seong Woo surname: Choi fullname: Choi, Seong Woo organization: National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea – sequence: 5 givenname: Nari surname: Kim fullname: Kim, Nari organization: National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea – sequence: 6 givenname: Tae-Hoon surname: Choi fullname: Choi, Tae-Hoon organization: Department of Sport and Leisure Studies, Andong Science College, Andong 760-709, Korea – sequence: 7 givenname: Hyun Joo surname: Youn fullname: Youn, Hyun Joo organization: Department of Microbiology and School of Biotechnology & Biomedical Science, Inje University, Gimhae 621-749, Korea – sequence: 8 givenname: Su-Hyun surname: Jo fullname: Jo, Su-Hyun organization: Department of Physiology, Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon 200-701, Korea – sequence: 9 givenname: Da Hye surname: Hong fullname: Hong, Da Hye organization: National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea – sequence: 10 givenname: Jin surname: Han fullname: Han, Jin organization: National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 613-735, Korea |
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| CitedBy_id | crossref_primary_10_1007_s00210_016_1232_8 crossref_primary_10_5483_BMBRep_2011_44_9_559 crossref_primary_10_3892_etm_2020_8472 |
| Cites_doi | 10.1126/science.3194754 10.1016/0092-8674(95)90340-2 10.1124/mol.54.1.220 10.1016/S0092-8674(01)00243-4 10.1016/S0735-1097(00)00716-6 10.1038/sj.bjp.0703777 10.1016/j.intimp.2007.10.022 10.1161/ATVBAHA.107.143339 10.1161/01.RES.73.5.968 10.1007/BF02976958 10.1073/pnas.87.8.2975 10.1007/s10529-004-8294-2 10.1038/384080a0 10.1540/jsmr.44.65 10.1177/153537020523000111 10.1007/BF02976959 10.1161/01.RES.77.1.140 10.1023/A:1025482516404 10.1002/ptr.1358 10.1113/expphysiol.1996.sp003962 10.1161/01.RES.79.1.79 10.1161/01.CIR.0000068344.54010.B3 10.1016/j.vascn.2008.05.129 10.1007/BF02974179 10.1097/FJC.0b013e31817dd013 10.1085/jgp.96.1.195 10.1111/j.1469-7793.2000.t01-2-00391.x 10.1113/expphysiol.1996.sp003961 10.1211/0022357001774561 10.1248/bpb.28.921 |
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| Keywords | Long QT syndrome Ventricular myocyte Delayed rectifier K+ current Artemisia iwayomogi |
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| Snippet | We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier... We investigated the effects of a hot-water extract of Artemisia iwayomogi , a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K... We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K＋... |
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| Title | A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K + Channels in Rabbit Ventricular Myocytes |
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