A Novel Self-Micro-Emulsifying Delivery System Enhances Enrichment of Eicosapentaenoic Acid and Docosahexaenoic Acid after Single and Repeated Dosing in Healthy Adults in a Randomized Trial

• Published in: The Journal of nutrition Vol. 148; no. 11; pp. 1704 - 1715
• Main Authors: West, Annette L, Kindberg, Grete Mørk, Hustvedt, Svein Olaf, Calder, Philip C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018; American Institute of Nutrition
• Subjects: Adult; Adults; bioavailability; blood flow; breakfast; Cells; Clinical trials; Docosahexaenoic acid; Docosahexaenoic Acids - administration & dosage; Docosahexaenoic Acids - chemistry; Dosage; Double-Blind Method; Drug Administration Schedule; Drug Delivery Systems; Drug dosages; Drug Therapy, Combination; Eicosapentaenoic acid; Eicosapentaenoic Acid - administration & dosage; Eicosapentaenoic Acid - chemistry; Emulsification; emulsifying; Emulsions - chemistry; erythrocytes; Esters; Ethyl esters; Evidence-based medicine; fasting; Fatty acids; Female; fish oil; Formulations; Humans; Leukocytes (mononuclear); Male; Middle Aged; omega-3; omega-3 fatty acids; omega-3 index; Plasma; SMEDS; Stomach; EE; Cmax; emulsification; MNC; fish oil; omega-3 index; SMEDS; BHT; eicosapentaenoic acid; omega-3; bioavailability; docosahexaenoic acid; iAUC; Tmax

A self-micro-emulsifying delivery system (SMEDS) promotes spontaneous emulsification of omega-3 (n–3) ethyl esters (EEs) into microdroplets in the stomach. The objective was to compare the effect of SMEDS preparations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) EEs with standard EE...