Hepatitis D virus and liver transplantation: Indications and outcomes

Hepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV i...

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Published inWorld journal of hepatology Vol. 13; no. 3; pp. 291 - 299
Main Authors Muhammad, Haris, Tehreem, Aniqa, Hammami, Muhammad Baraa, Ting, Peng-Sheng, Idilman, Ramzan, Gurakar, Ahmet
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 27.03.2021
Subjects
Minireviews
Liver transplant
Hepatocellular carcinoma
Hepatitis B immunoglobins
Hepatitis delta virus
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Abstract Hepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV and hepatitis B virus coinfection is uncommon in the United States, most data on the long-term impact of LT on HDV are from international centers. In this review, we discuss the indications and results of LT with treatment options in HDV patients.
AbstractList Hepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV and hepatitis B virus coinfection is uncommon in the United States, most data on the long-term impact of LT on HDV are from international centers. In this review, we discuss the indications and results of LT with treatment options in HDV patients.
Author Idilman, Ramzan
Hammami, Muhammad Baraa
Gurakar, Ahmet
Muhammad, Haris
Ting, Peng-Sheng
Tehreem, Aniqa
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  organization: Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MA 21205, United States. aguraka1@jhmi.edu
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Keywords Liver transplant
Hepatocellular carcinoma
Hepatitis B immunoglobins
Hepatitis delta virus
Language English
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This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
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Author contributions: Muhammad H, Tehreem A and Hammami MB participated in paper design, literature review and writing of the manuscript; Ting PS and Idilman R contributed to critical review and revisions of the manuscript; Gurakar A contributed in paper design, literature review, critical review and revisions of the manuscript; all authors have read and approved the final manuscript.
Corresponding author: Ahmet Gurakar, MD, Associate Professor, Director, Doctor, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Suite 918, Baltimore, MA 21205, United States. aguraka1@jhmi.edu
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