Local delivery of chlorhexidine using a tooth-bonded delivery system

• Published in: Journal of controlled release Vol. 61; no. 3; pp. 337 - 343
• Main Authors: Medlicott, Natalie J, Holborow, Doug W, Rathbone, Michael J, Jones, David S, Tucker, Ian G
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.09.1999; Elsevier
• Subjects: Administration, Oral; Anti-Infective Agents, Local - administration & dosage; Anti-Infective Agents, Local - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiseptics; Biological and medical sciences; Chlorhexidine; Chlorhexidine - administration & dosage; Chlorhexidine - pharmacokinetics; Dental Bonding; Drug Delivery Systems; General pharmacology; Humans; Medical sciences; Mouthwashes - administration & dosage; Mouthwashes - pharmacokinetics; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Poly(ε-caprolactone) films; Polyesters - administration & dosage; Saliva - metabolism; Saliva concentration; Tooth-bonded; Chlorhexidine; Poly(ε-caprolactone) films; Tooth-bonded; Saliva concentration; Encapsulation; Human; Pharmaceutical technology; Healthy subject; Control release polymer; Slow release form; Drug carrier; Biological activity; Oral cavity; Antiseptic; Dosage form; Tooth; Disinfecting agent; Polycaprolactone; Saliva
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/S0168-3659(99)00152-2

Films containing 20% w/w chlorhexidine base (particle size 63–125 μm) in poly(ε-caprolactone), MW 35 000–45 000, were prepared by solvent evaporation and sections attached to the mesio-lingual and mesio-buccal surfaces of the lower first molar in healthy volunteers. Saliva (<1.5 μl) was collected on Periopaper ® and chlorhexidine concentrations measured by HPLC were typically higher in the area immediately adjacent to the tooth-bonded film sections and lower at more distant sites. Analysis of variance of chlorhexidine concentrations, adjacent to the film sections, showed concentrations were significantly different on the buccal and lingual sides of the tooth and depended on the time of sampling ( n=5, P<0.05).