Comparative phenotypic analysis and genome sequence of Clostridium beijerinckii SA-1, an offspring of NCIMB 8052

• Published in: Microbiology (Society for General Microbiology) Vol. 159; no. Pt 12; pp. 2558 - 2570
• Main Authors: Sandoval-Espinola, Walter J, Makwana, Satya T, Chinn, Mari S, Thon, Michael R, Azcárate-Peril, M Andrea, Bruno-Bárcena, José M
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 01.12.2013
• Subjects: Butanols - metabolism; Butanols - toxicity; Carbon - metabolism; Clostridium beijerinckii - drug effects; Clostridium beijerinckii - genetics; Clostridium beijerinckii - growth & development; Clostridium beijerinckii - metabolism; Culture Media - chemistry; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; Fructose - metabolism; Genes and Genomes; Genome, Bacterial; Glucose - metabolism; Growth Inhibitors - toxicity; Metabolic Networks and Pathways - genetics; Molecular Sequence Data; Polymorphism, Genetic; Sequence Analysis, DNA; Solvents - metabolism; Solvents - toxicity

Production of butanol by solventogenic clostridia is controlled through metabolic regulation of the carbon flow and limited by its toxic effects. To overcome cell sensitivity to solvents, stress-directed evolution methodology was used three decades ago on Clostridium beijerinckii NCIMB 8052 that spa...