Pulsed release of nitroglycerin from transdermal drug delivery systems

• Published in: International journal of pharmaceutics Vol. 193; no. 1; pp. 57 - 61
• Main Authors: Gröning, R, Kuhland, U
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.12.1999; Elsevier
• Subjects: Administration, Cutaneous; Biological and medical sciences; Delayed-Action Preparations - pharmacokinetics; Drug Delivery Systems - methods; Gas producing cell; Gases - chemical synthesis; General pharmacology; Medical sciences; Nitroglycerin; Nitroglycerin - pharmacokinetics; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Propylene Glycol; Pulsatile Flow; Pulsed release; Time Factors; Transdermal system; Tube reservoir; Pulsed release; Transdermal system; Tube reservoir; Gas producing cell; Nitroglycerin; Pharmaceutical technology; Controlled release form; Hydrogen; In vitro; Percutaneous route; Gases; Manufacturing process; Formulation; Dosage form; Skin; Propanediol; Patch; Release

To achieve a discontinuous drug delivery to the skin a new actively controlled transdermal system has been developed. The system consists of a tube shaped drug reservoir in combination with an electronic circuit and a gas producing cell. A magnetic switch was used to control the onset of the product...