Outcomes of Two Trials of Oxygen-Saturation Targets in Preterm Infants
In two trials involving preterm infants, an oxygen-saturation target of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or disability at 2 years but in significantly increased risks of the combined outcome and of death alone in post hoc combined analyses. The determinat...
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| Published in | The New England journal of medicine Vol. 374; no. 8; pp. 749 - 760 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Massachusetts Medical Society
25.02.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0028-4793 1533-4406 |
| DOI | 10.1056/NEJMoa1514212 |
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| Abstract | In two trials involving preterm infants, an oxygen-saturation target of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or disability at 2 years but in significantly increased risks of the combined outcome and of death alone in post hoc combined analyses.
The determination of the range of oxygen saturation that minimizes the competing risks of death, retinopathy of prematurity, and later disability in preterm infants is important.
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The U.K. and Australian Benefits of Oxygen Saturation Targeting (BOOST)–II trials are two of five comparative effectiveness trials of the targeting of oxygen saturation in infants born before 28 weeks’ gestation.
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These trials, known collectively as the Neonatal Oxygen Prospective Meta-analysis (NeOProM) Collaboration, were designed to compare the effects of a lower oxygen-saturation target range (85 to 89%) versus a higher target range (91 to 95%) on a primary outcome of death . . . |
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| AbstractList | In two trials involving preterm infants, an oxygen-saturation target of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or disability at 2 years but in significantly increased risks of the combined outcome and of death alone in post hoc combined analyses.
The determination of the range of oxygen saturation that minimizes the competing risks of death, retinopathy of prematurity, and later disability in preterm infants is important.
1
,
2
The U.K. and Australian Benefits of Oxygen Saturation Targeting (BOOST)–II trials are two of five comparative effectiveness trials of the targeting of oxygen saturation in infants born before 28 weeks’ gestation.
3
–
8
These trials, known collectively as the Neonatal Oxygen Prospective Meta-analysis (NeOProM) Collaboration, were designed to compare the effects of a lower oxygen-saturation target range (85 to 89%) versus a higher target range (91 to 95%) on a primary outcome of death . . . BackgroundThe safest ranges of oxygen saturation in preterm infants have been the subject of debate.MethodsIn two trials, conducted in Australia and the United Kingdom, infants born before 28 weeks’ gestation were randomly assigned to either a lower (85 to 89%) or a higher (91 to 95%) oxygen-saturation range. During enrollment, the oximeters were revised to correct a calibration-algorithm artifact. The primary outcome was death or disability at a corrected gestational age of 2 years; this outcome was evaluated among infants whose oxygen saturation was measured with any study oximeter in the Australian trial and those whose oxygen saturation was measured with a revised oximeter in the U.K. trial.ResultsAfter 1135 infants in Australia and 973 infants in the United Kingdom had been enrolled in the trial, an interim analysis showed increased mortality at a corrected gestational age of 36 weeks, and enrollment was stopped. Death or disability in the Australian trial (with all oximeters included) occurred in 247 of 549 infants (45.0%) in the lower-target group versus 217 of 545 infants (39.8%) in the higher-target group (adjusted relative risk, 1.12; 95% confidence interval [CI], 0.98 to 1.27; P=0.10); death or disability in the U.K. trial (with only revised oximeters included) occurred in 185 of 366 infants (50.5%) in the lower-target group versus 164 of 357 infants (45.9%) in the higher-target group (adjusted relative risk, 1.10; 95% CI, 0.97 to 1.24; P=0.15). In post hoc combined, unadjusted analyses that included all oximeters, death or disability occurred in 492 of 1022 infants (48.1%) in the lower-target group versus 437 of 1013 infants (43.1%) in the higher-target group (relative risk, 1.11; 95% CI, 1.01 to 1.23; P=0.02), and death occurred in 222 of 1045 infants (21.2%) in the lower-target group versus 185 of 1045 infants (17.7%) in the higher-target group (relative risk, 1.20; 95% CI, 1.01 to 1.43; P=0.04). In the group in which revised oximeters were used, death or disability occurred in 287 of 580 infants (49.5%) in the lower-target group versus 248 of 563 infants (44.0%) in the higher-target group (relative risk, 1.12; 95% CI, 0.99 to 1.27; P=0.07), and death occurred in 144 of 587 infants (24.5%) versus 99 of 586 infants (16.9%) (relative risk, 1.45; 95% CI, 1.16 to 1.82; P=0.001).ConclusionsUse of an oxygen-saturation target range of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or disability at 2 years in each trial but in significantly increased risks of this combined outcome and of death alone in post hoc combined analyses. (Funded by the Australian National Health and Medical Research Council and others; BOOST-II Current Controlled Trials number, ISRCTN00842661, and Australian New Zealand Clinical Trials Registry number, ACTRN12605000055606.) The safest ranges of oxygen saturation in preterm infants have been the subject of debate. In two trials, conducted in Australia and the United Kingdom, infants born before 28 weeks' gestation were randomly assigned to either a lower (85 to 89%) or a higher (91 to 95%) oxygen-saturation range. During enrollment, the oximeters were revised to correct a calibration-algorithm artifact. The primary outcome was death or disability at a corrected gestational age of 2 years; this outcome was evaluated among infants whose oxygen saturation was measured with any study oximeter in the Australian trial and those whose oxygen saturation was measured with a revised oximeter in the U.K. trial. After 1135 infants in Australia and 973 infants in the United Kingdom had been enrolled in the trial, an interim analysis showed increased mortality at a corrected gestational age of 36 weeks, and enrollment was stopped. Death or disability in the Australian trial (with all oximeters included) occurred in 247 of 549 infants (45.0%) in the lower-target group versus 217 of 545 infants (39.8%) in the higher-target group (adjusted relative risk, 1.12; 95% confidence interval [CI], 0.98 to 1.27; P=0.10); death or disability in the U.K. trial (with only revised oximeters included) occurred in 185 of 366 infants (50.5%) in the lower-target group versus 164 of 357 infants (45.9%) in the higher-target group (adjusted relative risk, 1.10; 95% CI, 0.97 to 1.24; P=0.15). In post hoc combined, unadjusted analyses that included all oximeters, death or disability occurred in 492 of 1022 infants (48.1%) in the lower-target group versus 437 of 1013 infants (43.1%) in the higher-target group (relative risk, 1.11; 95% CI, 1.01 to 1.23; P=0.02), and death occurred in 222 of 1045 infants (21.2%) in the lower-target group versus 185 of 1045 infants (17.7%) in the higher-target group (relative risk, 1.20; 95% CI, 1.01 to 1.43; P=0.04). In the group in which revised oximeters were used, death or disability occurred in 287 of 580 infants (49.5%) in the lower-target group versus 248 of 563 infants (44.0%) in the higher-target group (relative risk, 1.12; 95% CI, 0.99 to 1.27; P=0.07), and death occurred in 144 of 587 infants (24.5%) versus 99 of 586 infants (16.9%) (relative risk, 1.45; 95% CI, 1.16 to 1.82; P=0.001). Use of an oxygen-saturation target range of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or disability at 2 years in each trial but in significantly increased risks of this combined outcome and of death alone in post hoc combined analyses. (Funded by the Australian National Health and Medical Research Council and others; BOOST-II Current Controlled Trials number, ISRCTN00842661, and Australian New Zealand Clinical Trials Registry number, ACTRN12605000055606.). |
| Author | Donoghoe, Mark Deshpande, Sanjeev Cairns, Pamela Luig, Melissa Fleck, Brian W Stenson, Ben Marlow, Neil Hague, Wendy Tarnow-Mordi, William Evans, Nicholas Juszczak, Edmund Dargaville, Peter Fielder, Alistair R Stack, Jacqueline Williams, Cathy Ghadge, Alpana Davis, Peter G Darlow, Brian A Kirby, Adrienne Morley, Colin Gebski, Val Malcolm, Girvan Pritchard, Margo Kecskes, Zsuzsoka Brocklehurst, Peter Doyle, Lex W Kluckow, Martin Gray, Peter H King, Andrew Wardle, Stephen P Headley, Bevan Simes, R John Tin, Win Halliday, Henry L Simmer, Karen Wright, Ian Keech, Anthony Gole, Glen Tan, Kenneth Morris, Scott |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26863265$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1136/fn.84.2.F106 10.1001/jama.2010.310 10.1038/pr.2014.10 10.1093/ptj/80.10.974 10.1136/adc.2008.141531 10.1017/S0012162204000635 10.1136/adc.2010.206011 10.1001/jama.2013.5555 10.1136/adc.2007.119271 10.1136/adc.2007.135285 10.1111/apa.12692 10.1016/j.siny.2015.10.001 10.1056/NEJMc1101319 10.1186/1471-2431-11-6 10.1542/peds.112.6.1415 10.1016/j.jpeds.2014.05.028 10.1002/sim.5893 10.1542/peds.113.2.394 10.1056/NEJMoa1208506 10.1016/j.jpeds.2014.03.004 10.1038/jp.2014.199 10.1016/j.jpeds.2014.01.017 10.1056/NEJMoa1302298 10.1159/000326797 10.1159/000356561 10.1056/NEJMsa0806033 10.1001/jamapediatrics.2014.3307 |
| ContentType | Journal Article |
| Copyright | Copyright © 2016 Massachusetts Medical Society. All rights reserved. |
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| References | Schmidt, B, Whyte, RK, Asztalos, EV (r006) 2013; 309 Rosychuk, RJ, Hudson-Mason, A, Eklund, D, Lacaze-Masmonteil, T (r021) 2012; 101 Johnson, S, Moore, T, Marlow, N (r012) 2014; 75 Schmidt, B, Roberts, RS, Whyte, RK (r015) 2014; 165 Saugstad, OD, Aune, D (r024) 2014; 105 Draper, ES, Zeitlin, J, Fenton, AC (r027) 2009; 94 Carlo, WA, Finer, NN, Walsh, MC (r004) 2010; 362 Stenson, B, Brocklehurst, P, Tarnow-Mordi, W (r011) 2011; 364 Cole, CH, Wright, KW, Tarnow-Mordi, W, Phelps, DL (r001) 2003; 112 Askie, LM, Brocklehurst, P, Darlow, BA, Finer, N, Schmidt, B, Tarnow-Mordi, W (r003) 2011; 11 Stenson, BJ, Tarnow-Mordi, WO, Darlow, BA (r008) 2013; 368 Jones, JG, Lockwood, GG, Fung, N (r023) Vaucher, YE, Peralta-Carcelen, M, Finer, NN (r005) 2012; 367 Askie, LM, Darlow, BA, Davis, PG (r020) 2014 Sola, A, Golombek, SG, Montes Bueno, MT (r028) 2014; 103 Johnson, S, Marlow, N, Wolke, D (r014) 2004; 46 Field, D, Bajuk, B, Manktelow, BN (r026) 2008; 93 Manja, V, Lakshminrusimha, S, Cook, DJ (r025) 2015; 169 Silverman, WA (r002) 2004; 113 Palisano, RJ, Hanna, SE, Rosenbaum, PL (r013) 2000; 80 Lakshminrusimha, S, Manja, V, Mathew, B, Suresh, GK (r016) 2015; 35 Bassler, D, Briel, M, Montori, VM (r018) 2010; 303 Schmidt, B, Whyte, RK, Roberts, RS (r017) 2014; 165 Schou, IM, Marschner, IC (r019) 2013; 32 Quine, D, Stenson, BJ (r022) 2009; 94 Johnston, ED, Boyle, B, Juszczak, E, King, A, Brocklehurst, P, Stenson, BJ (r010) 2011; 96 Tarnow-Mordi, W, Cruz, M, Morris, J (r029) 2015; 20 Darlow, BA, Marschner, SL, Donoghoe, M (r007) 2014; 165 Tin, W, Milligan, DW, Pennefather, P, Hey, E (r009) 2001; 84 r021 r022 r001 Johnson S (r014) 2004; 46 r017 r018 r019 r015 r016 Jones JG (r023) Palisano RJ (r013) 2000; 80 r010 r011 r012 r006 r028 r007 r029 r008 r009 r002 r024 r003 r025 r004 r026 r005 r027 Askie LM (r020) 2014 28134454 - Acta Paediatr. 2017 Jun;106(6):1014. doi: 10.1111/apa.13730. |
| References_xml | – volume: 367 start-page: 2495 year: 2012 end-page: 2504 ident: r005 article-title: Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial. publication-title: N Engl J Med – volume: 94 start-page: F158 year: 2009 end-page: 63 ident: r027 article-title: Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort. publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 93 start-page: F212 year: 2008 end-page: 6 ident: r026 article-title: Geographically based investigation of the influence of very-preterm births on routine mortality statistics from the UK and Australia. publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 35 start-page: 8 year: 2015 end-page: 15 ident: r016 article-title: Oxygen targeting in preterm infants: a physiological interpretation. publication-title: J Perinatol – volume: 84 start-page: F106 year: 2001 end-page: 10 ident: r009 article-title: Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 165 start-page: 666 year: 2014 end-page: 71.e2 ident: r015 article-title: Impact of study oximeter masking algorithm on titration of oxygen therapy in the Canadian Oxygen Trial. publication-title: J Pediatr – volume: 46 start-page: 389 year: 2004 end-page: 397 ident: r014 article-title: Validation of a parent report measure of cognitive development in very preterm infants. publication-title: Dev Med Child Neurol – volume: 112 start-page: 1415 year: 2003 end-page: 1419 ident: r001 article-title: Resolving our uncertainty about oxygen therapy. publication-title: Pediatrics – volume: 364 start-page: 1680 year: 2011 end-page: 1682 ident: r011 article-title: Increased 36-week survival with high oxygen saturation target in extremely preterm infants. publication-title: N Engl J Med – volume: 165 start-page: 6 year: 2014 end-page: 8 ident: r017 article-title: Trade-off between lower or higher oxygen saturations for extremely preterm infants: the first Benefits of Oxygen Saturation Targeting (BOOST) II trial reports its primary outcome. publication-title: J Pediatr – volume: 32 start-page: 4859 year: 2013 end-page: 4874 ident: r019 article-title: Meta-analysis of clinical trials with early stopping: an investigation of potential bias. publication-title: Stat Med – volume: 368 start-page: 2094 year: 2013 end-page: 2104 ident: r008 article-title: Oxygen saturation and outcomes in preterm infants. publication-title: N Engl J Med – volume: 101 start-page: 14 year: 2012 end-page: 19 ident: r021 article-title: Discrepancies between arterial oxygen saturation and functional oxygen saturation measured with pulse oximetry in very preterm infants. publication-title: Neonatology – volume: 75 start-page: 670 year: 2014 end-page: 674 ident: r012 article-title: Using the Bayley-III to assess neurodevelopmental delay: which cut-off should be used? publication-title: Pediatr Res – volume: 362 start-page: 1959 year: 2010 end-page: 1969 ident: r004 article-title: Target ranges of oxygen saturation in extremely preterm infants. publication-title: N Engl J Med – volume: 103 start-page: 1009 year: 2014 end-page: 1018 ident: r028 article-title: Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia? publication-title: Acta Paediatr – volume: 94 start-page: F51 year: 2009 end-page: 3 ident: r022 article-title: Arterial oxygen tension (Pao2) values in infants <29 weeks of gestation at currently targeted saturations. publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 80 start-page: 974 year: 2000 end-page: 985 ident: r013 article-title: Validation of a model of gross motor function for children with cerebral palsy. publication-title: Phys Ther – volume: 20 start-page: 389 year: 2015 end-page: 402 ident: r029 article-title: Design and conduct of a large obstetric or neonatal randomized controlled trial. publication-title: Semin Fetal Neonatal Med – volume: 113 start-page: 394 year: 2004 end-page: 396 ident: r002 article-title: A cautionary tale about supplemental oxygen: the albatross of neonatal medicine. publication-title: Pediatrics – volume: 96 start-page: F429 year: 2011 end-page: 33 ident: r010 article-title: Oxygen targeting in preterm infants using the Masimo SET Radical pulse oximeter. publication-title: Arch Dis Child Fetal Neonatal Ed – ident: r023 article-title: Influence of pulmonary factors on pulse oximeter saturation in pre-term infants. publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 309 start-page: 2111 year: 2013 end-page: 2120 ident: r006 article-title: Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial. publication-title: JAMA – volume: 105 start-page: 55 year: 2014 end-page: 63 ident: r024 article-title: Optimal oxygenation of extremely low birth weight infants: a meta-analysis and systematic review of the oxygen saturation target studies. publication-title: Neonatology – volume: 165 start-page: 30 year: 2014 end-page: 5.e2. ident: r007 article-title: Randomized controlled trial of oxygen saturation targets in very preterm infants: two year outcomes. publication-title: J Pediatr – volume: 303 start-page: 1180 year: 2010 end-page: 1187 ident: r018 article-title: Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. publication-title: JAMA – volume: 169 start-page: 332 year: 2015 end-page: 340 ident: r025 article-title: Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis. publication-title: JAMA Pediatr – volume: 11 start-page: 6 year: 2011 end-page: 6 ident: r003 article-title: NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol. publication-title: BMC Pediatr – start-page: CD011190 year: 2014 end-page: CD011190 ident: r020 article-title: Effects of targeting higher versus lower arterial oxygen saturations on death or disability in preterm infants (protocol). publication-title: Cochrane Database Syst Rev – ident: r009 doi: 10.1136/fn.84.2.F106 – ident: r018 doi: 10.1001/jama.2010.310 – ident: r012 doi: 10.1038/pr.2014.10 – volume: 80 start-page: 974 year: 2000 ident: r013 publication-title: Phys Ther doi: 10.1093/ptj/80.10.974 – ident: r027 doi: 10.1136/adc.2008.141531 – volume: 46 start-page: 389 year: 2004 ident: r014 publication-title: Dev Med Child Neurol doi: 10.1017/S0012162204000635 – ident: r010 doi: 10.1136/adc.2010.206011 – start-page: CD011190 year: 2014 ident: r020 publication-title: Cochrane Database Syst Rev – ident: r006 doi: 10.1001/jama.2013.5555 – ident: r026 doi: 10.1136/adc.2007.119271 – ident: r022 doi: 10.1136/adc.2007.135285 – ident: r028 doi: 10.1111/apa.12692 – ident: r029 doi: 10.1016/j.siny.2015.10.001 – ident: r011 doi: 10.1056/NEJMc1101319 – ident: r003 doi: 10.1186/1471-2431-11-6 – ident: r001 doi: 10.1542/peds.112.6.1415 – ident: r015 doi: 10.1016/j.jpeds.2014.05.028 – ident: r019 doi: 10.1002/sim.5893 – ident: r023 publication-title: Arch Dis Child Fetal Neonatal Ed – ident: r002 doi: 10.1542/peds.113.2.394 – ident: r005 doi: 10.1056/NEJMoa1208506 – ident: r017 doi: 10.1016/j.jpeds.2014.03.004 – ident: r016 doi: 10.1038/jp.2014.199 – ident: r007 doi: 10.1016/j.jpeds.2014.01.017 – ident: r008 doi: 10.1056/NEJMoa1302298 – ident: r021 doi: 10.1159/000326797 – ident: r024 doi: 10.1159/000356561 – ident: r004 doi: 10.1056/NEJMsa0806033 – ident: r025 doi: 10.1001/jamapediatrics.2014.3307 – reference: 28134454 - Acta Paediatr. 2017 Jun;106(6):1014. doi: 10.1111/apa.13730. |
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| Snippet | In two trials involving preterm infants, an oxygen-saturation target of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or... The safest ranges of oxygen saturation in preterm infants have been the subject of debate. In two trials, conducted in Australia and the United Kingdom,... BackgroundThe safest ranges of oxygen saturation in preterm infants have been the subject of debate.MethodsIn two trials, conducted in Australia and the United... BACKGROUNDThe safest ranges of oxygen saturation in preterm infants have been the subject of debate.METHODSIn two trials, conducted in Australia and the United... |
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| SubjectTerms | Australia Child, Preschool Clinical trials Death Developmental Disabilities - epidemiology Female Gestational age Humans Infant Infant Mortality Infant, Extremely Premature - blood Infant, Newborn Infants Male Medical research Newborn babies Oximetry Oxygen Oxygen - blood Oxygen Inhalation Therapy - adverse effects Oxygen Inhalation Therapy - methods Oxygen saturation Premature babies Premature birth Risk United Kingdom |
| Title | Outcomes of Two Trials of Oxygen-Saturation Targets in Preterm Infants |
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