A commensal strain of Staphylococcus epidermidis protects against skin neoplasia

• Published in: Science advances Vol. 4; no. 2; p. eaao4502
• Main Authors: Nakatsuji, Teruaki, Chen, Tiffany H., Butcher, Anna M., Trzoss, Lynnie L., Nam, Sang-Jip, Shirakawa, Karina T., Zhou, Wei, Oh, Julia, Otto, Michael, Fenical, William, Gallo, Richard L.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 01.02.2018
• Subjects: Adenine - analogs & derivatives; Adenine - chemistry; Adenine - metabolism; Adenine - pharmacology; Animals; Cell Line, Tumor; Cell Proliferation - drug effects; Female; Health and Medicine; Humans; Melanoma, Experimental - pathology; Membrane Proteins - metabolism; Mice; SciAdv r-articles; Skin - drug effects; Skin - microbiology; Skin Neoplasms - microbiology; Skin Neoplasms - pathology; Staphylococcus epidermidis - drug effects; Staphylococcus epidermidis - isolation & purification; Staphylococcus epidermidis - physiology; Ultraviolet Rays

Bacteria within the skin microbiome of some individuals produce an antimetabolite that inhibits tumor growth. We report the discovery that strains of Staphylococcus epidermidis produce 6- N -hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively i...