Perfluorodecanoic acid (PFDA) increases oxidative stress through inhibition of mitochondrial β-oxidation

• Published in: Environmental pollution (1987) Vol. 367; p. 125595
• Main Authors: Widhalm, Raimund, Granitzer, Sebastian, Natha, Benjamin, Zoboli, Ottavia, Derx, Julia, Zeisler, Harald, Salzer, Hans, Weiss, Stefan, Schmitner, Nicole, Kimmel, Robin A., Österreicher, Tamina, Oberle, Raimund, Hengstschläger, Markus, Distel, Martin, Gundacker, Claudia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.02.2025
• Subjects: Animals; Cell Line; Danio rerio; Decanoic Acids - toxicity; Environmental Pollutants - toxicity; fatty acids; Fluorocarbons - toxicity; Glutathione; Humans; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Oxidation-Reduction; oxidative stress; Oxidative Stress - drug effects; Placenta; pollution; Toxicity; tricarboxylic acid cycle; Zebrafish; Zebrafish; Placenta; Toxicity; Glutathione

Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic organic chemicals that are ubiquitous environmental pollutants. Among PFAS, perfluorodecanoic acid (PFDA) is one of the most toxic compounds, but the molecular basis behind its toxicity is not fully understood. In an interspec...