Differences in clinical characteristics of IgG4-related disease across age groups: a prospective study of 737 patients
Abstract Objective The aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups. Methods We conducted a prospective study of 737 patients who were newly diagnosed with IgG4-RD and compared detailed demographic features, organ involvem...
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| Published in | Rheumatology (Oxford, England) Vol. 60; no. 6; pp. 2635 - 2646 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford University Press
18.06.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Abstract
Objective
The aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups.
Methods
We conducted a prospective study of 737 patients who were newly diagnosed with IgG4-RD and compared detailed demographic features, organ involvements, laboratory tests, treatments and outcomes across age groups. The patients were divided into five groups according to their age at diagnosis: ≤39, 40–49, 50–59, 60–69 and ≥70 years. The clinical characteristics of paediatric patients were also described.
Results
Sex ratio, disease duration, allergy history and clinical symptoms were significantly different across age groups. Besides, the proportions of superficial organ involvement (lacrimal gland and sinus) decreased with age, while the proportions of internal organ involvement (pancreas, biliary tract, retroperitoneal tissue, lung and prostate) increased with age, which was more prominent in male patients. Mikulicz’s disease was the most common manifestation (70%) in paediatric IgG4-RD patients. Multiple Cox analysis identified that age ≤56 years at diagnosis was an independent risk factor of relapse.
Conclusion
We revealed the impact of age on clinical characteristics of IgG4-RD, which indicated that different management might be required among different age groups. |
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| AbstractList | The aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups.OBJECTIVEThe aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups.We conducted a prospective study of 737 patients who were newly diagnosed with IgG4-RD and compared detailed demographic features, organ involvements, laboratory tests, treatments and outcomes across age groups. The patients were divided into five groups according to their age at diagnosis: ≤39, 40-49, 50-59, 60-69 and ≥70 years. The clinical characteristics of paediatric patients were also described.METHODSWe conducted a prospective study of 737 patients who were newly diagnosed with IgG4-RD and compared detailed demographic features, organ involvements, laboratory tests, treatments and outcomes across age groups. The patients were divided into five groups according to their age at diagnosis: ≤39, 40-49, 50-59, 60-69 and ≥70 years. The clinical characteristics of paediatric patients were also described.Sex ratio, disease duration, allergy history and clinical symptoms were significantly different across age groups. Besides, the proportions of superficial organ involvement (lacrimal gland and sinus) decreased with age, while the proportions of internal organ involvement (pancreas, biliary tract, retroperitoneal tissue, lung and prostate) increased with age, which was more prominent in male patients. Mikulicz's disease was the most common manifestation (70%) in paediatric IgG4-RD patients. Multiple Cox analysis identified that age ≤56 years at diagnosis was an independent risk factor of relapse.RESULTSSex ratio, disease duration, allergy history and clinical symptoms were significantly different across age groups. Besides, the proportions of superficial organ involvement (lacrimal gland and sinus) decreased with age, while the proportions of internal organ involvement (pancreas, biliary tract, retroperitoneal tissue, lung and prostate) increased with age, which was more prominent in male patients. Mikulicz's disease was the most common manifestation (70%) in paediatric IgG4-RD patients. Multiple Cox analysis identified that age ≤56 years at diagnosis was an independent risk factor of relapse.We revealed the impact of age on clinical characteristics of IgG4-RD, which indicated that different management might be required among different age groups.CONCLUSIONWe revealed the impact of age on clinical characteristics of IgG4-RD, which indicated that different management might be required among different age groups. Abstract Objective The aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups. Methods We conducted a prospective study of 737 patients who were newly diagnosed with IgG4-RD and compared detailed demographic features, organ involvements, laboratory tests, treatments and outcomes across age groups. The patients were divided into five groups according to their age at diagnosis: ≤39, 40–49, 50–59, 60–69 and ≥70 years. The clinical characteristics of paediatric patients were also described. Results Sex ratio, disease duration, allergy history and clinical symptoms were significantly different across age groups. Besides, the proportions of superficial organ involvement (lacrimal gland and sinus) decreased with age, while the proportions of internal organ involvement (pancreas, biliary tract, retroperitoneal tissue, lung and prostate) increased with age, which was more prominent in male patients. Mikulicz’s disease was the most common manifestation (70%) in paediatric IgG4-RD patients. Multiple Cox analysis identified that age ≤56 years at diagnosis was an independent risk factor of relapse. Conclusion We revealed the impact of age on clinical characteristics of IgG4-RD, which indicated that different management might be required among different age groups. |
| Author | Peng, Linyi Lu, Hui Zhang, Panpan Wang, Mu Fei, Yunyun Liu, Xiaowei Zhou, Jiaxin Luo, Xuan Zhu, Liang Wang, Liwen Zeng, Xiaofeng Teng, Fei Li, Jieqiong Zhao, Yan Zhang, Wen Liu, Zheng |
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Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 4 givenname: Yunyun orcidid: 0000-0003-1728-2342 surname: Fei fullname: Fei, Yunyun organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 5 givenname: Linyi surname: Peng fullname: Peng, Linyi organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 6 givenname: Jiaxin surname: Zhou fullname: Zhou, Jiaxin organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 7 givenname: Mu surname: Wang fullname: Wang, Mu organization: Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China – sequence: 8 givenname: Xiaowei surname: Liu fullname: Liu, Xiaowei organization: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China – sequence: 9 givenname: Liang surname: Zhu fullname: Zhu, Liang organization: Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China – sequence: 10 givenname: Liwen orcidid: 0000-0003-2918-2402 surname: Wang fullname: Wang, Liwen organization: Department of General Surgery, RuiJin Hospital affiliated to Shanghai Jiao Tong University School of medicine, Shanghai, China – sequence: 11 givenname: Xuan surname: Luo fullname: Luo, Xuan organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 12 givenname: Zheng surname: Liu fullname: Liu, Zheng organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 13 givenname: Jieqiong surname: Li fullname: Li, Jieqiong organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 14 givenname: Yan surname: Zhao fullname: Zhao, Yan organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 15 givenname: Wen surname: Zhang fullname: Zhang, Wen email: zhangwen91@sina.com organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China – sequence: 16 givenname: Xiaofeng surname: Zeng fullname: Zeng, Xiaofeng organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China |
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| Cites_doi | 10.1016/j.exger.2012.11.014 10.1038/modpathol.2012.72 10.1136/ard.2008.089169 10.1186/s12969-016-0079-3 10.3389/fimmu.2017.01960 10.1177/0961203314526291 10.1007/s10067-015-3031-x 10.1002/art.39132 10.1093/rheumatology/key397 10.1002/acr.23543 10.1177/0961203316644333 10.3389/fimmu.2013.00271 10.1080/14397595.2017.1416891 10.1016/S0140-6736(14)60720-0 10.1177/0961203314547790 10.1038/nri3547 10.1038/s41598-017-06520-5 10.1007/s11357-012-9488-5 10.3389/fnins.2015.00172 10.1186/ar4540 10.1016/S2665-9913(19)30017-7 10.1016/j.molmed.2010.03.003 10.3109/03009742.2013.822094 10.1186/ar4571 10.1007/s10875-010-9499-x 10.1136/ard.2005.051144 10.1016/j.arr.2017.04.001 10.1016/j.arr.2010.08.004 10.1007/s00535-016-1302-1 10.1016/j.jaci.2018.02.017 10.1186/s13075-018-1567-2 10.1111/j.1474-9726.2012.00851.x 10.1136/gutjnl-2012-303617 10.1111/ggi.13662 10.1186/s13075-017-1324-y 10.1093/rheumatology/keu228 10.1111/joim.12942 10.1034/j.1398-9995.2001.t01-1-00001.x 10.1186/s13075-020-02197-w 10.1093/rheumatology/kez669 10.1002/art.39205 10.1016/j.smim.2012.04.009 10.3109/s10165-011-0571-z 10.1016/j.cgh.2009.03.021 10.5001/omj.2018.20 |
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| Copyright_xml | – notice: The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2020 – notice: The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
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| References | Lin (2021061821304323500_keaa651-B29) 2014; 16 Boeters (2021061821304323500_keaa651-B14) 2017; 19 Kirkland (2021061821304323500_keaa651-B11) 2013; 48 Nikolich-Zugich (2021061821304323500_keaa651-B45) 2012; 24 Fulop (2021061821304323500_keaa651-B13) 2017; 8 Hong (2021061821304323500_keaa651-B27) 2015; 18 Masaki (2021061821304323500_keaa651-B34) 2009; 68 Umehara (2021061821304323500_keaa651-B3) 2012; 22 Arnold (2021061821304323500_keaa651-B43) 2011; 31 Wallace (2021061821304323500_keaa651-B33) 2018; 70 Deshpande (2021061821304323500_keaa651-B5) 2012; 25 Khosroshahi (2021061821304323500_keaa651-B6) 2015; 67 Saeki (2021061821304323500_keaa651-B35) 2018; 28 Ambrose (2021061821304323500_keaa651-B18) 2016; 25 Hearps (2021061821304323500_keaa651-B47) 2012; 11 Fulop (2021061821304323500_keaa651-B46) 2013; 4 Kamisawa (2021061821304323500_keaa651-B1) 2015; 385 Yunyun (2021061821304323500_keaa651-B10) 2017; 7 Chen (2021061821304323500_keaa651-B32) 2014; 43 Blanco (2021061821304323500_keaa651-B39) 2018; 141 Sandanayake (2021061821304323500_keaa651-B9) 2009; 7 Zhang (2021061821304323500_keaa651-B21) 2019; 1 Yamamoto (2021061821304323500_keaa651-B24) 2019; 19 Peng (2021061821304323500_keaa651-B41) 2019; 286 Yamamoto (2021061821304323500_keaa651-B23) 2015; 54 Ruban (2021061821304323500_keaa651-B16) 2016; 35 Innala (2021061821304323500_keaa651-B15) 2014; 16 Freund (2021061821304323500_keaa651-B48) 2010; 16 Shaw (2021061821304323500_keaa651-B12) 2013; 13 Johansson (2021061821304323500_keaa651-B26) 2001; 56 Bulati (2021061821304323500_keaa651-B30) 2017; 36 Deleidi (2021061821304323500_keaa651-B37) 2015; 9 Merola (2021061821304323500_keaa651-B20) 2014; 23 Karim (2021061821304323500_keaa651-B42) 2016; 14 Umehara (2021061821304323500_keaa651-B25) 2012; 22 Hart (2021061821304323500_keaa651-B8) 2013; 62 Wang (2021061821304323500_keaa651-B28) 2019; 58 Wang (2021061821304323500_keaa651-B40) 2018; 20 Vaglio (2021061821304323500_keaa651-B2) 2012; 366 Kubota (2021061821304323500_keaa651-B7) 2017; 52 Wallace (2021061821304323500_keaa651-B36) 2015; 67 Frasca (2021061821304323500_keaa651-B44) 2011; 10 Liu (2021061821304323500_keaa651-B22) 2020; 59 Peng (2021061821304323500_keaa651-B38) 2020; 22 Al-Mujaini (2021061821304323500_keaa651-B4) 2018; 33 Tutuncu (2021061821304323500_keaa651-B17) 2006; 65 Terao (2021061821304323500_keaa651-B19) 2014; 23 Buffa (2021061821304323500_keaa651-B31) 2013; 35 |
| References_xml | – volume: 48 start-page: 1 year: 2013 ident: 2021061821304323500_keaa651-B11 article-title: Translating advances from the basic biology of aging into clinical application publication-title: Exp Gerontol doi: 10.1016/j.exger.2012.11.014 – volume: 25 start-page: 1181 year: 2012 ident: 2021061821304323500_keaa651-B5 article-title: Consensus statement on the pathology of IgG4-related disease publication-title: Mod Pathol doi: 10.1038/modpathol.2012.72 – volume: 68 start-page: 1310 year: 2009 ident: 2021061821304323500_keaa651-B34 article-title: Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders publication-title: Ann Rheum Dis doi: 10.1136/ard.2008.089169 – volume: 14 start-page: 18 year: 2016 ident: 2021061821304323500_keaa651-B42 article-title: IgG4-related disease: a systematic review of this unrecognized disease in pediatrics publication-title: Pediatr Rheumatol Online J doi: 10.1186/s12969-016-0079-3 – volume: 8 start-page: 1960 year: 2017 ident: 2021061821304323500_keaa651-B13 article-title: Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes? publication-title: Front Immunol doi: 10.3389/fimmu.2017.01960 – volume: 23 start-page: 778 year: 2014 ident: 2021061821304323500_keaa651-B20 article-title: Clinical manifestations and survival among adults with (SLE) according to age at diagnosis publication-title: Lupus doi: 10.1177/0961203314526291 – volume: 35 start-page: 759 year: 2016 ident: 2021061821304323500_keaa651-B16 article-title: The influence of age at disease onset on disease activity and disability: results from the Ontario Best Practices Research Initiative publication-title: Clin Rheumatol doi: 10.1007/s10067-015-3031-x – volume: 67 start-page: 1688 year: 2015 ident: 2021061821304323500_keaa651-B6 article-title: International consensus guidance statement on the management and treatment of IgG4-related disease publication-title: Arthritis Rheumatol doi: 10.1002/art.39132 – volume: 58 start-page: 820 year: 2019 ident: 2021061821304323500_keaa651-B28 article-title: Sex disparities in clinical characteristics and prognosis of immunoglobulin G4-related disease: a prospective study of 403 patients publication-title: Rheumatology (Oxford doi: 10.1093/rheumatology/key397 – volume: 70 start-page: 1671 year: 2018 ident: 2021061821304323500_keaa651-B33 article-title: An international multispecialty validation study of the IgG4-related disease responder index publication-title: Arthritis Care Res (Hoboken) doi: 10.1002/acr.23543 – volume: 25 start-page: 1542 year: 2016 ident: 2021061821304323500_keaa651-B18 article-title: Differences in disease phenotype and severity in SLE across age groups publication-title: Lupus doi: 10.1177/0961203316644333 – volume: 4 start-page: 271 year: 2013 ident: 2021061821304323500_keaa651-B46 article-title: Human T cell aging and the impact of persistent viral infections publication-title: Front Immunol doi: 10.3389/fimmu.2013.00271 – volume: 28 start-page: 845 year: 2018 ident: 2021061821304323500_keaa651-B35 article-title: Comparison of clinical and laboratory features of patients with and without allergic conditions in IgG4-related disease: a single-center experience in Japan publication-title: Mod Rheumatol doi: 10.1080/14397595.2017.1416891 – volume: 385 start-page: 1460 year: 2015 ident: 2021061821304323500_keaa651-B1 article-title: IgG4-related disease publication-title: Lancet doi: 10.1016/S0140-6736(14)60720-0 – volume: 23 start-page: 1435 year: 2014 ident: 2021061821304323500_keaa651-B19 article-title: A nationwide study of SLE in Japanese identified subgroups of patients with clear signs patterns and associations between signs and age or sex publication-title: Lupus doi: 10.1177/0961203314547790 – volume: 13 start-page: 875 year: 2013 ident: 2021061821304323500_keaa651-B12 article-title: Age-dependent dysregulation of innate immunity publication-title: Nat Rev Immunol doi: 10.1038/nri3547 – volume: 7 start-page: 6195 year: 2017 ident: 2021061821304323500_keaa651-B10 article-title: Efficacy of cyclophosphamide treatment for immunoglobulin G4-related disease with addition of glucocorticoids publication-title: Sci Rep doi: 10.1038/s41598-017-06520-5 – volume: 35 start-page: 2009 year: 2013 ident: 2021061821304323500_keaa651-B31 article-title: A novel B cell population revealed by a CD38/CD24 gating strategy: CD38CD24 B cells in centenarian offspring and elderly people publication-title: Age (Dordr doi: 10.1007/s11357-012-9488-5 – volume: 9 start-page: 172 year: 2015 ident: 2021061821304323500_keaa651-B37 article-title: Immune aging, dysmetabolism, and inflammation in neurological diseases publication-title: Front Neurosci doi: 10.3389/fnins.2015.00172 – volume: 16 start-page: R94 year: 2014 ident: 2021061821304323500_keaa651-B15 article-title: Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study publication-title: Arthritis Res Ther doi: 10.1186/ar4540 – volume: 1 start-page: e55 year: 2019 ident: 2021061821304323500_keaa651-B21 article-title: Management of IgG4-related disease publication-title: Lancet Rheumatol doi: 10.1016/S2665-9913(19)30017-7 – volume: 16 start-page: 238 year: 2010 ident: 2021061821304323500_keaa651-B48 article-title: Inflammatory networks during cellular senescence: causes and consequences publication-title: Trends Mol Med doi: 10.1016/j.molmed.2010.03.003 – volume: 43 start-page: 70 year: 2014 ident: 2021061821304323500_keaa651-B32 article-title: IgG4-related disease in a Chinese cohort: a prospective study publication-title: Scand J Rheumatol doi: 10.3109/03009742.2013.822094 – volume: 16 start-page: R118 year: 2014 ident: 2021061821304323500_keaa651-B29 article-title: B cell subsets and dysfunction of regulatory B cells in IgG4-related diseases and primary Sjögren's syndrome: the similarities and differences publication-title: Arthritis Res Ther doi: 10.1186/ar4571 – volume: 31 start-page: 137 year: 2011 ident: 2021061821304323500_keaa651-B43 article-title: Gain and loss of T cell subsets in old age—age-related reshaping of the T cell repertoire publication-title: J Clin Immunol doi: 10.1007/s10875-010-9499-x – volume: 366 start-page: 1646 year: 2012 ident: 2021061821304323500_keaa651-B2 article-title: IgG4-related disease publication-title: N Engl J Med – volume: 65 start-page: 1226 year: 2006 ident: 2021061821304323500_keaa651-B17 article-title: Do patients with older-onset rheumatoid arthritis receive less aggressive treatment? publication-title: Ann Rheum Dis doi: 10.1136/ard.2005.051144 – volume: 36 start-page: 125 year: 2017 ident: 2021061821304323500_keaa651-B30 article-title: From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing” publication-title: Ageing Res Rev doi: 10.1016/j.arr.2017.04.001 – volume: 10 start-page: 330 year: 2011 ident: 2021061821304323500_keaa651-B44 article-title: Age effects on B cells and humoral immunity in humans publication-title: Ageing Res Rev doi: 10.1016/j.arr.2010.08.004 – volume: 52 start-page: 955 year: 2017 ident: 2021061821304323500_keaa651-B7 article-title: Low-dose maintenance steroid treatment could reduce the relapse rate in patients with type 1 autoimmune pancreatitis: a long-term Japanese multicenter analysis of 510 patients publication-title: J Gastroenterol doi: 10.1007/s00535-016-1302-1 – volume: 141 start-page: 2208 year: 2018 ident: 2021061821304323500_keaa651-B39 article-title: Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2018.02.017 – volume: 22 start-page: 1 year: 2012 ident: 2021061821304323500_keaa651-B3 article-title: A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details publication-title: Oman Med J – volume: 20 start-page: 65 year: 2018 ident: 2021061821304323500_keaa651-B40 article-title: Failure of remission induction by glucocorticoids alone or in combination with immunosuppressive agents in IgG4-related disease: a prospective study of 215 patients publication-title: Arthritis Res Ther doi: 10.1186/s13075-018-1567-2 – volume: 11 start-page: 867 year: 2012 ident: 2021061821304323500_keaa651-B47 article-title: Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function publication-title: Aging cell doi: 10.1111/j.1474-9726.2012.00851.x – volume: 62 start-page: 1771 year: 2013 ident: 2021061821304323500_keaa651-B8 article-title: Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis publication-title: Gut doi: 10.1136/gutjnl-2012-303617 – volume: 19 start-page: 564 year: 2019 ident: 2021061821304323500_keaa651-B24 article-title: Differences in clinical features of immunoglobulin G4-related disease between older and younger patients publication-title: Geriatr Gerontol Int doi: 10.1111/ggi.13662 – volume: 19 start-page: 115 year: 2017 ident: 2021061821304323500_keaa651-B14 article-title: The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical publication-title: Arthritis Res Ther doi: 10.1186/s13075-017-1324-y – volume: 54 start-page: 45 year: 2015 ident: 2021061821304323500_keaa651-B23 article-title: Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/keu228 – volume: 286 start-page: 542 year: 2019 ident: 2021061821304323500_keaa651-B41 article-title: Clinical outcomes and predictive relapse factors of IgG4-related disease following treatment: a long-term cohort study publication-title: J Intern Med doi: 10.1111/joim.12942 – volume: 56 start-page: 813 year: 2001 ident: 2021061821304323500_keaa651-B26 article-title: A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force publication-title: Allergy doi: 10.1034/j.1398-9995.2001.t01-1-00001.x – volume: 18 start-page: 85 year: 2015 ident: 2021061821304323500_keaa651-B27 article-title: Internal organ involvement in IgG4-related sialadenitis: a systemic review publication-title: Chin J Dent Res – volume: 22 start-page: 103 year: 2020 ident: 2021061821304323500_keaa651-B38 article-title: IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of IgG4-related disease publication-title: Arthritis Res Ther doi: 10.1186/s13075-020-02197-w – volume: 59 start-page: 2115 year: 2020 ident: 2021061821304323500_keaa651-B22 article-title: Relapse predictors and serologically unstable condition of IgG4-related disease: a large Chinese cohort publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/kez669 – volume: 67 start-page: 2466 year: 2015 ident: 2021061821304323500_keaa651-B36 article-title: IgG4-related disease: clinical and laboratory features in one hundred twenty-five patients publication-title: Arthritis Rheumatol doi: 10.1002/art.39205 – volume: 24 start-page: 356 year: 2012 ident: 2021061821304323500_keaa651-B45 article-title: Age-related changes in CD8 T cell homeostasis and immunity to infection publication-title: Semin Immunol doi: 10.1016/j.smim.2012.04.009 – volume: 22 start-page: 21 year: 2012 ident: 2021061821304323500_keaa651-B25 article-title: Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 publication-title: Mod Rheumatol doi: 10.3109/s10165-011-0571-z – volume: 7 start-page: 1089 year: 2009 ident: 2021061821304323500_keaa651-B9 article-title: Presentation and management of post-treatment relapse in autoimmune pancreatitis/immunoglobulin G4-associated cholangitis publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2009.03.021 – volume: 33 start-page: 97 year: 2018 ident: 2021061821304323500_keaa651-B4 article-title: Immunoglobulin G4-related disease: An update publication-title: Oman Med J doi: 10.5001/omj.2018.20 |
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Objective
The aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups.
Methods
We... The aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups.OBJECTIVEThe aim of this study... |
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