Recent advances in all-protein chromophore technology

The green fluorescent protein (GFP) is the foundation of a powerful technology that has revolutionized the way in which the life scientist carries out experiments in the living cell. The technology is continually evolving and improving through the development of existing proteins and discovery of ne...

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Bibliographic Details
Published inBiotechnology Annual Review Vol. 12; pp. 31 - 66
Main Authors Prescott, Mark, Battad, Jion M., Wilmann, Pascal G., Rossjohn, Jamie, Devenish, Rodney J.
Format Book Chapter Journal Article
LanguageEnglish
Published The Netherlands Elsevier Science & Technology 2006
Subjects
Aequorea victoria
Biochemistry
Biotechnology
Biotechnology - methods
Fluorescence Recovery After Photobleaching
Fluorescence Resonance Energy Transfer
Luminescent Proteins - chemistry
Luminescent Proteins - genetics
Luminescent Proteins - metabolism
Models, Molecular
Molecular Structure
Protein Conformation
Protein Engineering - methods
Spectrometry, Fluorescence
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Summary:The green fluorescent protein (GFP) is the foundation of a powerful technology that has revolutionized the way in which the life scientist carries out experiments in the living cell. The technology is continually evolving and improving through the development of existing proteins and discovery of new members of the all-protein chromophore (APC) family. This review gives an overview of the more recent advances in the technology with a particular focus on APCs having optical properties that are significantly red-shifted relative to those variants derived from Aequorea victoria GFP.
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ISBN:9780444527240
0444527249
ISSN:1387-2656
1875-5208
DOI:10.1016/S1387-2656(06)12002-5