Processing of carbamazepine–PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution

• Published in: International journal of pharmaceutics Vol. 222; no. 1; pp. 129 - 138
• Main Authors: Moneghini, M., Kikic, I., Voinovich, D., Perissutti, B., Filipović-Grčić, J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 03.07.2001; Elsevier
• Subjects: Biological and medical sciences; Carbamazepine; Crystallization; Gas antisolvent crystallisation; General pharmacology; Medical sciences; Microscopy, Electron, Scanning; PEG 4000; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physico-chemical characterisation; Polyethylene Glycols; Solid dispersions; Supercritical fluids; Technology, Pharmaceutical; X-Ray Diffraction; Supercritical fluids; Solid dispersions; Gas antisolvent crystallisation; PEG 4000; Physico-chemical characterisation; Carbamazepine; Particle size; Pharmaceutical technology; Control release polymer; Carbon dioxide; Solid dispersion; Drug carrier; Tricyclic compound; Dissolution; Ethylene oxide polymer; Dosage form; Supercritical fluid extraction; Supercritical process; Dibenzazepine derivatives; Physicochemical properties

The purpose of this study was to apply the attractive technique of the supercritical fluid to the preparation of solvent-free solid dispersions. In particular, the gas antisolvent crystallisation technique (GAS), using supercritical carbon dioxide as processing medium, has been considered to prepare...