Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis
Malignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing pleomorphic adenoma. An alternative classification, malignant mixed tumor-not otherwise (MMT-NOS), is a diagnosis of exclusion for neoplasms that do...
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Published in | American journal of otolaryngology Vol. 42; no. 6; p. 103135 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.11.2021
Elsevier Limited |
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Abstract | Malignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing pleomorphic adenoma. An alternative classification, malignant mixed tumor-not otherwise (MMT-NOS), is a diagnosis of exclusion for neoplasms that do not fit the previous histologically profiled subtypes. The objective was to provide a comprehensive assessment of MMT-NOS and determine prognostic factors.
This retrospective cohort study queried the Surveillance, Epidemiology, and End Results database for patient and tumor characteristics of US patients with MMT-NOS of the major salivary glands from 1973 to 2016. Kaplan-Meier and Cox regression analysis were performed to determine 5-year survival and prognostic factors.
434 patients were identified with a mean age at diagnosis of 61.5 years. The majority of neoplasms were high grade and stage (70.8% grade III/IV; 63.8% stage III/IV). Extraparenchymal extension (40.6%) and lymph node involvement (28.5%) were common; distant metastases (2.4%) were rare. Treatment included surgery (93.0%), radiation (51.6%), and chemotherapy (10.4%). Facial nerve sacrifice was common (50.8%). Median survival was 66.5 months. 5-year overall and disease-specific survival were 65.7% and 83.0%, respectively. In multivariate analysis, nodal involvement (HR 7.0; P < 0.001), surgery-radiation-chemotherapy (HR 6.1; P = 0.02), extraparenchymal extension (HR 2.50; P = 0.04), and tumor size >4 cm (HR 1.3; P = 0.03) were prognostic factors.
Despite high stage and grade at diagnosis, MMT-NOS portends a good 5-year prognosis and low rate of distant metastasis. Prognostic factors were nodal involvement, tumor size, and extraparenchymal extension. |
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AbstractList | ObjectiveMalignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing pleomorphic adenoma. An alternative classification, malignant mixed tumor-not otherwise (MMT-NOS), is a diagnosis of exclusion for neoplasms that do not fit the previous histologically profiled subtypes. The objective was to provide a comprehensive assessment of MMT-NOS and determine prognostic factors.MethodsThis retrospective cohort study queried the Surveillance, Epidemiology, and End Results database for patient and tumor characteristics of US patients with MMT-NOS of the major salivary glands from 1973 to 2016. Kaplan-Meier and Cox regression analysis were performed to determine 5-year survival and prognostic factors.Results434 patients were identified with a mean age at diagnosis of 61.5 years. The majority of neoplasms were high grade and stage (70.8% grade III/IV; 63.8% stage III/IV). Extraparenchymal extension (40.6%) and lymph node involvement (28.5%) were common; distant metastases (2.4%) were rare. Treatment included surgery (93.0%), radiation (51.6%), and chemotherapy (10.4%). Facial nerve sacrifice was common (50.8%). Median survival was 66.5 months. 5-year overall and disease-specific survival were 65.7% and 83.0%, respectively. In multivariate analysis, nodal involvement (HR 7.0; P < 0.001), surgery-radiation-chemotherapy (HR 6.1; P = 0.02), extraparenchymal extension (HR 2.50; P = 0.04), and tumor size >4 cm (HR 1.3; P = 0.03) were prognostic factors.ConclusionDespite high stage and grade at diagnosis, MMT-NOS portends a good 5-year prognosis and low rate of distant metastasis. Prognostic factors were nodal involvement, tumor size, and extraparenchymal extension. Malignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing pleomorphic adenoma. An alternative classification, malignant mixed tumor-not otherwise (MMT-NOS), is a diagnosis of exclusion for neoplasms that do not fit the previous histologically profiled subtypes. The objective was to provide a comprehensive assessment of MMT-NOS and determine prognostic factors. This retrospective cohort study queried the Surveillance, Epidemiology, and End Results database for patient and tumor characteristics of US patients with MMT-NOS of the major salivary glands from 1973 to 2016. Kaplan-Meier and Cox regression analysis were performed to determine 5-year survival and prognostic factors. 434 patients were identified with a mean age at diagnosis of 61.5 years. The majority of neoplasms were high grade and stage (70.8% grade III/IV; 63.8% stage III/IV). Extraparenchymal extension (40.6%) and lymph node involvement (28.5%) were common; distant metastases (2.4%) were rare. Treatment included surgery (93.0%), radiation (51.6%), and chemotherapy (10.4%). Facial nerve sacrifice was common (50.8%). Median survival was 66.5 months. 5-year overall and disease-specific survival were 65.7% and 83.0%, respectively. In multivariate analysis, nodal involvement (HR 7.0; P < 0.001), surgery-radiation-chemotherapy (HR 6.1; P = 0.02), extraparenchymal extension (HR 2.50; P = 0.04), and tumor size >4 cm (HR 1.3; P = 0.03) were prognostic factors. Despite high stage and grade at diagnosis, MMT-NOS portends a good 5-year prognosis and low rate of distant metastasis. Prognostic factors were nodal involvement, tumor size, and extraparenchymal extension. |
ArticleNumber | 103135 |
Author | Chisholm, Jaime Soffer, Justin M. Nassif, Samih J. O'Leary, Miriam A. Von Plato, Michael |
Author_xml | – sequence: 1 givenname: Justin M. surname: Soffer fullname: Soffer, Justin M. email: justin.soffer@tufts.edu organization: Tufts University School of Medicine, 145 Harrison St, Boston, MA 02111, United States of America – sequence: 2 givenname: Samih J. surname: Nassif fullname: Nassif, Samih J. organization: Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center, 800 Washington St, Boston, MA 02111, United States of America – sequence: 3 givenname: Michael surname: Von Plato fullname: Von Plato, Michael organization: Department of Radiology, Harbor-University of California, Los Angeles Medical Center, 1000 West Carson St, Box 23, Torrance, CA 90509, United States of America – sequence: 4 givenname: Jaime surname: Chisholm fullname: Chisholm, Jaime organization: Neely Center for Clinical Cancer Research, Tufts Medical Center, 800 Washington St, Boston, MA 02111, United States of America – sequence: 5 givenname: Miriam A. surname: O'Leary fullname: O'Leary, Miriam A. organization: Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center, 800 Washington St, Boston, MA 02111, United States of America |
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Keywords | Malignant mixed tumor-not otherwise specified Salivary gland SEER Malignant mixed tumor Survival Prognostic factors |
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Snippet | Malignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing... ObjectiveMalignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing... OBJECTIVEMalignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing... |
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SubjectTerms | Adenoma Adenoma, Pleomorphic - epidemiology Adenoma, Pleomorphic - mortality Adenoma, Pleomorphic - pathology Adenoma, Pleomorphic - therapy Age Chemotherapy Demographics Diagnosis Divorce Epidemiology Ethnicity Exocrine glands Facial nerve Female Hispanic people Humans Lymph nodes Lymph Nodes - pathology Lymphatic system Male Malignant mixed tumor Malignant mixed tumor-not otherwise specified Medical prognosis Metastases Metastasis Middle Aged Mixed Tumor, Malignant - epidemiology Mixed Tumor, Malignant - mortality Mixed Tumor, Malignant - pathology Mixed Tumor, Malignant - therapy Mortality Multivariate analysis Neoplasm Staging Neoplasms Oral cancer Otolaryngology Patients Prognosis Prognostic factors Radiation Regression analysis Retrospective Studies Salivary gland Salivary Gland Neoplasms - epidemiology Salivary Gland Neoplasms - mortality Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - therapy Salivary glands Salivary Glands - pathology SEER SEER Program Surgery Survival Survival analysis Survival Rate Tumors |
Title | Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis |
URI | https://dx.doi.org/10.1016/j.amjoto.2021.103135 https://www.ncbi.nlm.nih.gov/pubmed/34171696 https://www.proquest.com/docview/2576478771/abstract/ https://search.proquest.com/docview/2545593984 |
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