Effects of κ-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission

• Published in: European journal of pharmacology Vol. 426; no. 1; pp. 25 - 34
• Main Authors: Collins, Stephanie L, D'Addario, Claudio, Izenwasser, Sari
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 24.08.2001; Elsevier
• Subjects: Analgesics - pharmacology; Animals; Autoradiography; Benzazepines - metabolism; Benzeneacetamides; Benzomorphans - pharmacology; Binding, Competitive - drug effects; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Carrier Proteins - drug effects; Carrier Proteins - metabolism; Cocaine; Cocaine - analogs & derivatives; Cocaine - metabolism; Cocaine - pharmacology; Dopamine; Dopamine - metabolism; Dopamine Plasma Membrane Transport Proteins; Drug addictions; Immunoautoradiography; Iodine Radioisotopes; Locomotor activity; Male; Medical sciences; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity - drug effects; Nerve Tissue Proteins; Pyrrolidines - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Dopamine - drug effects; Receptors, Dopamine - metabolism; Receptors, Opioid, kappa - agonists; Sensitization; Sulpiride - analogs & derivatives; Sulpiride - metabolism; Synaptic Transmission - drug effects; Time Factors; Toxicology; Tyrosine 3-Monooxygenase - drug effects; Tyrosine 3-Monooxygenase - metabolism; κ-Opioid receptor agonist; Autoradiography; Dopamine; Immunoautoradiography; Cocaine; Sensitization; Locomotor activity; κ-Opioid receptor agonist; Drug addiction; Agonist; Rat; Enzyme; Treatment efficiency; Rodentia; κ Opioid receptor; Catecholamine; Tyrosine 3-monooxygenase; Ester; Locomotion; Vertebrata; Chemotherapy; Chronic; Mammalia; Treatment; Animal; Drug of abuse; Oxidoreductases; Neurotransmission

κ-Opioid receptor agonists have been suggested as treatments for cocaine addiction based on studies showing that they block cocaine-related behaviors. To determine the effects of κ-opioid receptor agonists on long-term behavioral effects associated with cocaine and the neurochemical bases underlying...