Can growth hormone treatment in boys without growth hormone deficiency impair testicular function?
Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone–dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture a...
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| Published in | The Journal of pediatrics Vol. 135; no. 3; pp. 367 - 370 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.09.1999
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3476 1097-6833 |
| DOI | 10.1016/S0022-3476(99)70136-8 |
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| Abstract | Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone–dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture as determined by ultrasonography. No clinical or laboratory finding showed disease associated with testicular dysfunction. An unfavorable gonadal outcome could occur in boys without growth hormone deficiency treated with human growth hormone. (J Pediatr 1999;135:367-70) |
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| AbstractList | Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone–dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture as determined by ultrasonography. No clinical or laboratory finding showed disease associated with testicular dysfunction. An unfavorable gonadal outcome could occur in boys without growth hormone deficiency treated with human growth hormone. (J Pediatr 1999;135:367-70) Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone-dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture as determined by ultrasonography. No clinical or laboratory finding showed disease associated with testicular dysfunction. An unfavorable gonadal outcome could occur in boys without growth hormone deficiency treated with human growth hormone.Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone-dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture as determined by ultrasonography. No clinical or laboratory finding showed disease associated with testicular dysfunction. An unfavorable gonadal outcome could occur in boys without growth hormone deficiency treated with human growth hormone. Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone-dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture as determined by ultrasonography. No clinical or laboratory finding showed disease associated with testicular dysfunction. An unfavorable gonadal outcome could occur in boys without growth hormone deficiency treated with human growth hormone. |
| Author | Massimetti, Mauro Saggese, Giuseppe Bertelloni, Silvano Viacava, Paolo Simi, Paolo Baroncelli, Giampiero I. |
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| Keywords | hGH GH FSH SDS LH Human Small dimension Toxicity Somatotropin hormone Male Testicle Long term Genital diseases Case study Protein hormone Chemotherapy Hypergonadotropic hypogonadism Spermatogenesis disorders Treatment Adenohypophyseal hormone Volume Body size Adolescent Young adult Complication Child |
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| References | Paris, Menchetti, De Lazzaro, Marrocco, Nuzzo, Radicioni (bib8) 1998; 50 Kaleva, Arsalo, Louhimo, Rapola, Perheentupa, Henriksen (bib16) 1996; 19 Foresta, Ferlin, Garolla, Rossato, Barbaux, De Bortoli (bib6) 1997; 82 Brook (bib18) 1998; 87 Griffin, Wilson (bib9) 1992 Chatelain, Avallet, Nicolino, Lejeune, Clark, Chuzel (bib11) 1994; 399 Dunkel, Taskinen, Hovatta, Tilly, Wikstrom (bib15) 1997; 100 Taranger, Engstrom, Lichtenstein, Svennberg-Redegren (bib5) 1976 Spiteri-Grech, Neischlag (bib10) 1992; 38 World Health Organization (bib7) 1992 Rosenfeld (bib2) 1997; 130 Frish (bib1) 1998 Darendeliler, Hindmarsh, Preece, Cox, Brook (bib14) 1990; 122 De Boer, Schoemaker, van der Veen (bib12) 1997; 46 Siogren, Jonson, Madej, Hohansson, Ploen (bib17) 1998; 30 Tanner, Whitehouse (bib3) 1976; 51 Tanner, Whitehouse, Takaishi (bib4) 1966; 41 Kawai, Momoi, Yorifuji, Yamanaka, Sasaki, Furusho (bib13) 1997; 130 Foresta (10.1016/S0022-3476(99)70136-8_bib6) 1997; 82 Griffin (10.1016/S0022-3476(99)70136-8_bib9) 1992 Siogren (10.1016/S0022-3476(99)70136-8_bib17) 1998; 30 Frish (10.1016/S0022-3476(99)70136-8_bib1) 1998 Tanner (10.1016/S0022-3476(99)70136-8_bib3) 1976; 51 De Boer (10.1016/S0022-3476(99)70136-8_bib12) 1997; 46 Taranger (10.1016/S0022-3476(99)70136-8_bib5) 1976 Dunkel (10.1016/S0022-3476(99)70136-8_bib15) 1997; 100 Kaleva (10.1016/S0022-3476(99)70136-8_bib16) 1996; 19 Darendeliler (10.1016/S0022-3476(99)70136-8_bib14) 1990; 122 Tanner (10.1016/S0022-3476(99)70136-8_bib4) 1966; 41 Kawai (10.1016/S0022-3476(99)70136-8_bib13) 1997; 130 Paris (10.1016/S0022-3476(99)70136-8_bib8) 1998; 50 World Health Organization (10.1016/S0022-3476(99)70136-8_bib7) 1992 Rosenfeld (10.1016/S0022-3476(99)70136-8_bib2) 1997; 130 Brook (10.1016/S0022-3476(99)70136-8_bib18) 1998; 87 Spiteri-Grech (10.1016/S0022-3476(99)70136-8_bib10) 1992; 38 Chatelain (10.1016/S0022-3476(99)70136-8_bib11) 1994; 399 10484789 - J Pediatr. 1999 Sep;135(3):278-9 |
| References_xml | – volume: 122 start-page: 416 year: 1990 ident: bib14 article-title: Growth hormone increases rate of pubertal maturation publication-title: Acta Endocrinol (Copenh) – volume: 30 start-page: 37 year: 1998 end-page: 42 ident: bib17 article-title: Effects of very high doses of human growth hormone (hGH) on male reproductive system in the dog publication-title: Andrologia – volume: 82 start-page: 1075 year: 1997 end-page: 1080 ident: bib6 article-title: Y-chromosome deletion in idiopathic severe testiculopathies publication-title: J Clin Endocrinol Metab – volume: 87 start-page: 485 year: 1998 end-page: 486 ident: bib18 article-title: Views on growth hormone treatment in idiopathic shortness of stature publication-title: Acta Paediatr – volume: 51 start-page: 170 year: 1976 end-page: 179 ident: bib3 article-title: Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty publication-title: Arch Dis Child – volume: 100 start-page: 2341 year: 1997 end-page: 2346 ident: bib15 article-title: Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult publication-title: J Clin Invest – volume: 50 start-page: 303 year: 1998 ident: bib8 article-title: The spermiogram in adolescence publication-title: Minerva Pediatr – year: 1992 ident: bib7 article-title: WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction – start-page: 799 year: 1992 end-page: 852 ident: bib9 article-title: Disorders of the testes and the male reproductive tract publication-title: Wilsons textbook of endocrinology. – volume: 19 start-page: 293 year: 1996 end-page: 298 ident: bib16 article-title: Treatment with human chorionic gonadotrophin for cryptorchidism: clinical and histological effects publication-title: Int J Androl – volume: 399 start-page: 176 year: 1994 end-page: 177 ident: bib11 article-title: Insulin-like growth factor I actions on steroidogenesis publication-title: Acta Paediatr Suppl – volume: 130 start-page: 205 year: 1997 end-page: 209 ident: bib13 article-title: Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency publication-title: J Pediatr – volume: 46 start-page: 681 year: 1997 end-page: 689 ident: bib12 article-title: Impaired reproductive function in women treated for growth hormone deficiency publication-title: Clin Endocrinol (Oxf) – volume: 41 start-page: 454 year: 1966 end-page: 471 ident: bib4 article-title: Standards from birth to maturity for height, weight, height velocity and weight velocity: British children–1965 publication-title: Arch Dis Child – volume: 38 start-page: 22 year: 1992 end-page: 27 ident: bib10 article-title: The role of growth hormone and insulin-like growth factor I in the regulation of male reproductive function publication-title: Horm Res – start-page: 8 year: 1998 end-page: 24 ident: bib1 article-title: Clinical review of pediatric indications for treatment with growth hormone publication-title: Growth hormone over the human life span. – volume: 130 start-page: 172 year: 1997 end-page: 174 ident: bib2 article-title: Is growth hormone just a tall story? publication-title: J Pediatr – start-page: 121 year: 1976 end-page: 135 ident: bib5 article-title: Somatic pubertal development publication-title: Acta Paediatr Scand Suppl – start-page: 8 year: 1998 ident: 10.1016/S0022-3476(99)70136-8_bib1 article-title: Clinical review of pediatric indications for treatment with growth hormone – year: 1992 ident: 10.1016/S0022-3476(99)70136-8_bib7 – volume: 38 start-page: 22 issue: suppl 1 year: 1992 ident: 10.1016/S0022-3476(99)70136-8_bib10 article-title: The role of growth hormone and insulin-like growth factor I in the regulation of male reproductive function publication-title: Horm Res doi: 10.1159/000182566 – volume: 51 start-page: 170 year: 1976 ident: 10.1016/S0022-3476(99)70136-8_bib3 article-title: Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty publication-title: Arch Dis Child doi: 10.1136/adc.51.3.170 – volume: 399 start-page: 176 year: 1994 ident: 10.1016/S0022-3476(99)70136-8_bib11 article-title: Insulin-like growth factor I actions on steroidogenesis publication-title: Acta Paediatr Suppl doi: 10.1111/j.1651-2227.1994.tb13319.x – volume: 130 start-page: 205 year: 1997 ident: 10.1016/S0022-3476(99)70136-8_bib13 article-title: Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency publication-title: J Pediatr doi: 10.1016/S0022-3476(97)70344-5 – start-page: 121 issue: 258 year: 1976 ident: 10.1016/S0022-3476(99)70136-8_bib5 article-title: Somatic pubertal development publication-title: Acta Paediatr Scand Suppl doi: 10.1111/j.1651-2227.1976.tb14766.x – start-page: 799 year: 1992 ident: 10.1016/S0022-3476(99)70136-8_bib9 article-title: Disorders of the testes and the male reproductive tract – volume: 100 start-page: 2341 year: 1997 ident: 10.1016/S0022-3476(99)70136-8_bib15 article-title: Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult publication-title: J Clin Invest doi: 10.1172/JCI119773 – volume: 82 start-page: 1075 year: 1997 ident: 10.1016/S0022-3476(99)70136-8_bib6 article-title: Y-chromosome deletion in idiopathic severe testiculopathies publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.82.4.1075 – volume: 41 start-page: 454 year: 1966 ident: 10.1016/S0022-3476(99)70136-8_bib4 article-title: Standards from birth to maturity for height, weight, height velocity and weight velocity: British children–1965 publication-title: Arch Dis Child doi: 10.1136/adc.41.219.454 – volume: 122 start-page: 416 year: 1990 ident: 10.1016/S0022-3476(99)70136-8_bib14 article-title: Growth hormone increases rate of pubertal maturation publication-title: Acta Endocrinol (Copenh) – volume: 50 start-page: 303 year: 1998 ident: 10.1016/S0022-3476(99)70136-8_bib8 article-title: The spermiogram in adolescence publication-title: Minerva Pediatr – volume: 46 start-page: 681 year: 1997 ident: 10.1016/S0022-3476(99)70136-8_bib12 article-title: Impaired reproductive function in women treated for growth hormone deficiency publication-title: Clin Endocrinol (Oxf) doi: 10.1046/j.1365-2265.1997.1800999.x – volume: 130 start-page: 172 year: 1997 ident: 10.1016/S0022-3476(99)70136-8_bib2 article-title: Is growth hormone just a tall story? publication-title: J Pediatr – volume: 19 start-page: 293 year: 1996 ident: 10.1016/S0022-3476(99)70136-8_bib16 article-title: Treatment with human chorionic gonadotrophin for cryptorchidism: clinical and histological effects publication-title: Int J Androl doi: 10.1111/j.1365-2605.1996.tb00478.x – volume: 30 start-page: 37 year: 1998 ident: 10.1016/S0022-3476(99)70136-8_bib17 article-title: Effects of very high doses of human growth hormone (hGH) on male reproductive system in the dog publication-title: Andrologia doi: 10.1111/j.1439-0272.1998.tb01380.x – volume: 87 start-page: 485 year: 1998 ident: 10.1016/S0022-3476(99)70136-8_bib18 article-title: Views on growth hormone treatment in idiopathic shortness of stature publication-title: Acta Paediatr doi: 10.1111/j.1651-2227.1998.tb01488.x – reference: 10484789 - J Pediatr. 1999 Sep;135(3):278-9 |
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| SubjectTerms | Adolescent Adult Atrophy Biological and medical sciences Child Drug toxicity and drugs side effects treatment Follicle Stimulating Hormone - blood Follow-Up Studies Growth Disorders - drug therapy Human Growth Hormone - adverse effects Humans Hypogonadism - blood Hypogonadism - chemically induced Hypogonadism - diagnostic imaging Luteinizing Hormone - blood Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Testis - diagnostic imaging Testis - drug effects Testis - pathology Testosterone - blood Ultrasonography |
| Title | Can growth hormone treatment in boys without growth hormone deficiency impair testicular function? |
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