Tolcapone Improves Cognition and Cortical Information Processing in Normal Human Subjects - Apud, José A; Mattay, Venkata; Chen, Jingshan; Kolachana, Bhaskar S; Callicott, Joseph H; Rasetti, Roberta; Alce, Guilna; Iudicello, Jennifer E; Akbar, Natkai; Egan, Michael F; Goldberg, Terry E; Weinberger, Daniel R (Neuropsychopharmacology (New York, N.Y.), 2007)
Keywords: Adult; Amino Acid Substitution - genetics; Amphetamines; Behavioral Sciences; Benzophenones - adverse effects; Benzophenones - pharmacology; Biological and medical sciences; Biological Psychology; Brain Mapping; Catechol O-Methyltransferase - genetics; Catechol O-Methyltransferase - metabolism; Catechol O-Methyltransferase Inhibitors; Catecholamines; Cognition & reasoning; Cognition - drug effects; Cognition - physiology; Cross-Over Studies; Dopamine; Double-Blind Method; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - pharmacology; Enzymes; Executive function; Female; Genotype; Genotype & phenotype; Human subjects; Humans; Information processing; Magnetic Resonance Imaging; Male; Medical sciences; Medicine; Medicine & Public Health; Memory; Memory - drug effects; Memory - physiology; Mental disorders; Mental health; Middle Aged; Neuropsychological Tests; Neurosciences; Nitrophenols - adverse effects; Nitrophenols - pharmacology; original-article; Parkinson's disease; Pharmacotherapy; Placebos; Polymorphism; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiology; Psychiatry; Psychosis; Reference Values; Treatment Outcome; United States--US; fMRI; tolcapone; COMT; working memory; dorsolateral prefrontal cortex; DA; Human; Enzyme; Transferases; Dorsolateral cortex; Central nervous system; Enzyme inhibitor; Catechol O-methyltransferase; Cognition; Prefrontal cortex; Antiparkinson agent; Nuclear magnetic resonance imaging; Encephalon; Methyltransferases; Tolcapone; Information processing; Working memory; Functional imaging