Methionine enkephalin (MENK) regulates the immune pathogenesis of type 2 diabetes mellitus via the IL-33/ST2 pathway

• Published in: International immunopharmacology Vol. 73; pp. 23 - 40
• Main Authors: Zhang, Keying, Yang, Jing, Ao, Na, Jin, Shi, Qi, Ruiqun, Shan, Fengping, Du, Jian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2019; Elsevier BV
• Subjects: Animals; Blood Glucose - analysis; Cell Line, Tumor; Cytokines; Cytokines - blood; Cytokines - immunology; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - metabolism; Enkephalin, Methionine - pharmacology; Enkephalins; Glucose; Glucose metabolism; Immune system; INS-1; Insulin; Insulin - metabolism; Insulin resistance; Insulin secretion; Interleukin 10; Interleukin 2; Interleukin 5; Islet cells; Male; Methionine; Methionine enkephalin (MENK); MyD88 protein; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - metabolism; Neuroendocrine system; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Opioid receptors; Pancreas; Pancreas - drug effects; Pancreas - immunology; Pancreas - metabolism; Pathogenesis; Rats, Sprague-Dawley; Receptors, Interleukin-1 - immunology; Receptors, Opioid - genetics; Receptors, Opioid - metabolism; Serum levels; Signal Transduction - drug effects; TNF Receptor-Associated Factor 6 - genetics; TNF Receptor-Associated Factor 6 - metabolism; TRAF6 protein; Tumor necrosis factor-α; Type 2 diabetes mellitus (T2DM); Methionine enkephalin (MENK); INS-1; Opioid receptors; Pancreas; Type 2 diabetes mellitus (T2DM); Insulin secretion

The incidence and mortality of type 2 diabetes mellitus (T2DM) rank among the top ten worldwide. Emerging studies indicate pathological roles for the immune system in inflammation, insulin resistance and islet β-cell damage in subjects with T2DM. Methionine enkephalin (MENK) is present in endocrine...