Methionine enkephalin (MENK) regulates the immune pathogenesis of type 2 diabetes mellitus via the IL-33/ST2 pathway - Zhang, Keying; Yang, Jing; Ao, Na; Jin, Shi; Qi, Ruiqun; Shan, Fengping; Du, Jian (International immunopharmacology, 2019)
Keywords: Animals; Blood Glucose - analysis; Cell Line, Tumor; Cytokines; Cytokines - blood; Cytokines - immunology; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - metabolism; Enkephalin, Methionine - pharmacology; Enkephalins; Glucose; Glucose metabolism; Immune system; INS-1; Insulin; Insulin - metabolism; Insulin resistance; Insulin secretion; Interleukin 10; Interleukin 2; Interleukin 5; Islet cells; Male; Methionine; Methionine enkephalin (MENK); MyD88 protein; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - metabolism; Neuroendocrine system; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Opioid receptors; Pancreas; Pancreas - drug effects; Pancreas - immunology; Pancreas - metabolism; Pathogenesis; Rats, Sprague-Dawley; Receptors, Interleukin-1 - immunology; Receptors, Opioid - genetics; Receptors, Opioid - metabolism; Serum levels; Signal Transduction - drug effects; TNF Receptor-Associated Factor 6 - genetics; TNF Receptor-Associated Factor 6 - metabolism; TRAF6 protein; Tumor necrosis factor-α; Type 2 diabetes mellitus (T2DM); Methionine enkephalin (MENK); INS-1; Opioid receptors; Pancreas; Type 2 diabetes mellitus (T2DM); Insulin secretion