Polyomavirus Reactivation and Immune Responses to Kidney-Specific Self-Antigens in Transplantation

• Published in: Journal of the American Society of Nephrology Vol. 28; no. 4; pp. 1314 - 1325
• Main Authors: Seifert, Michael E., Gunasekaran, Muthukumar, Horwedel, Timothy A., Daloul, Reem, Storch, Gregory A., Mohanakumar, Thalachallour, Brennan, Daniel C.
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.04.2017
• Subjects: Autoantigens - blood; Case-Control Studies; Clinical Research; Cohort Studies; Female; Humans; Immunosuppression; Kidney - immunology; Kidney Transplantation; Male; Middle Aged; Polyomavirus - physiology; Polyomavirus Infections - blood; Polyomavirus Infections - immunology; Postoperative Complications - blood; Postoperative Complications - immunology; Postoperative Complications - virology; Retrospective Studies; Time Factors; Treatment Outcome; Tumor Virus Infections - blood; Tumor Virus Infections - immunology; Viremia - blood; Viremia - immunology; immunosuppression; virology; transplant outcomes; kidney transplantation

Humoral immune responses against donor antigens are important determinants of long-term transplant outcomes. Reactivation of the polyomavirus BK has been associated with de novo antibodies against mismatched donor HLA antigens in kidney transplantation. The effect of polyomavirus reactivation (BK vi...