Allergen induces CD11c+ dendritic cell autophagy to aggravate allergic rhinitis through promoting immune imbalance

• Published in: International immunopharmacology Vol. 106; p. 108611
• Main Authors: He, Yu-Qin, Qiao, Yue-Long, Xu, Shan, Jiao, Wo-Er, Yang, Rui, Kong, Yong-Gang, Tao, Ze-Zhang, Chen, Shi-Ming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2022; Elsevier BV
• Subjects: Adoptive transfer; Allergen; Allergens; Allergic rhinitis; Allergies; Autophagy; Bone marrow; CD11c antigen; CD11c+ dendritic cells; CD4 antigen; Cell differentiation; Cytokines; Dendritic cells; Differentiation (biology); Effector cells; Helper cells; Hypersensitivity; Immune imbalance; Inflammation; Inflammatory response; Lymphocytes; Lymphocytes T; Mucosa; p62 Protein; Phagosomes; Phenotypes; Protein expression; Proteins; Rhinitis; Spleen; T cells; CD; APCs; IL; IgE; MHC; T cells; Autophagy; P62; CBAs; AR; LC3II; IFN-γ; CD11c+ dendritic cells; Th; TNF-α; BMDC; GM-CSF; Allergic rhinitis; Immune imbalance; 3-MA; OVA; Allergen; DC; ATG5; CD11c(+) dendritic cells

•The nasal mucosa of mice in the AR group showed significantly increased LC3II expression, and co-expressed with DCs markers.•The degree of autophagy in DCs increased with the increase of allergen concentration in a dose-dependent manner.•Allergen-induced DCs autophagy aggravated AR by increasing an...