AHNAK2 is a novel prognostic marker and correlates with immune infiltration in papillary thyroid cancer: Evidence from integrated analysis
•AHNAK2 was identified as a valuable prognostic marker in PTC.•High expression of AHNAK2 correlated with worse clinical characteristics in PTC.•High expression of AHNAK2 correlated with tumor–related immune cell infiltration in PTC. Papillary thyroid cancer (PTC) is the most prevalent endocrine tumo...
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Published in | International immunopharmacology Vol. 90; p. 107185 |
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Language | English |
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Abstract | •AHNAK2 was identified as a valuable prognostic marker in PTC.•High expression of AHNAK2 correlated with worse clinical characteristics in PTC.•High expression of AHNAK2 correlated with tumor–related immune cell infiltration in PTC.
Papillary thyroid cancer (PTC) is the most prevalent endocrine tumor, and its incidence is still increasing. The mechanisms of PTC dedifferentiation and malignant progression remain unclear. In this study, we identified AHNAK2 as a key gene in PTC by differential expression analysis among four GEO datasets and validated its overexpression profile by data from the Oncomine, TCGA, and HPA databases and IHC staining analysis. AHNAK2 upregulation significantly correlated with advanced grades, stages, and lymph node events. Survival analysis suggested that AHNAK2 overexpression was coupled with poor overall survival. The immune infiltration analysis by TIMER and CIBERSORT indicated that AHNAK2 expression tightly correlated with the infiltration of diverse immune cell types, especially T cell subtypes. In addition, AHNAK2 is correlated with the expression of other conventional key genes of TC, such as PIK3CA, MAPK1, CTNNB1, and SLC5A5. AHNAK2 may be a novel prognostic marker for PTC. |
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AbstractList | Papillary thyroid cancer (PTC) is the most prevalent endocrine tumor, and its incidence is still increasing. The mechanisms of PTC dedifferentiation and malignant progression remain unclear. In this study, we identified AHNAK2 as a key gene in PTC by differential expression analysis among four GEO datasets and validated its overexpression profile by data from the Oncomine, TCGA, and HPA databases and IHC staining analysis. AHNAK2 upregulation significantly correlated with advanced grades, stages, and lymph node events. Survival analysis suggested that AHNAK2 overexpression was coupled with poor overall survival. The immune infiltration analysis by TIMER and CIBERSORT indicated that AHNAK2 expression tightly correlated with the infiltration of diverse immune cell types, especially T cell subtypes. In addition, AHNAK2 is correlated with the expression of other conventional key genes of TC, such as PIK3CA, MAPK1, CTNNB1, and SLC5A5. AHNAK2 may be a novel prognostic marker for PTC. •AHNAK2 was identified as a valuable prognostic marker in PTC.•High expression of AHNAK2 correlated with worse clinical characteristics in PTC.•High expression of AHNAK2 correlated with tumor–related immune cell infiltration in PTC. Papillary thyroid cancer (PTC) is the most prevalent endocrine tumor, and its incidence is still increasing. The mechanisms of PTC dedifferentiation and malignant progression remain unclear. In this study, we identified AHNAK2 as a key gene in PTC by differential expression analysis among four GEO datasets and validated its overexpression profile by data from the Oncomine, TCGA, and HPA databases and IHC staining analysis. AHNAK2 upregulation significantly correlated with advanced grades, stages, and lymph node events. Survival analysis suggested that AHNAK2 overexpression was coupled with poor overall survival. The immune infiltration analysis by TIMER and CIBERSORT indicated that AHNAK2 expression tightly correlated with the infiltration of diverse immune cell types, especially T cell subtypes. In addition, AHNAK2 is correlated with the expression of other conventional key genes of TC, such as PIK3CA, MAPK1, CTNNB1, and SLC5A5. AHNAK2 may be a novel prognostic marker for PTC. |
ArticleNumber | 107185 |
Author | Qu, Wei Zheng, Xianghong Zheng, Long Guo, Rong Li, Shanshan |
Author_xml | – sequence: 1 givenname: Long surname: Zheng fullname: Zheng, Long organization: Department of Nuclear Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China – sequence: 2 givenname: Shanshan surname: Li fullname: Li, Shanshan organization: Department of Epidemiology and Health Statistics, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China – sequence: 3 givenname: Xianghong surname: Zheng fullname: Zheng, Xianghong organization: Department of Nuclear Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China – sequence: 4 givenname: Rong surname: Guo fullname: Guo, Rong organization: Department of Nuclear Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China – sequence: 5 givenname: Wei surname: Qu fullname: Qu, Wei email: quwei96311@xjtu.edu.cn organization: Department of Nuclear Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33218938$$D View this record in MEDLINE/PubMed |
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Keywords | GEO Bioinformatic analysis Papillary thyroid cancer AHNAK2 Immune infiltration |
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Snippet | •AHNAK2 was identified as a valuable prognostic marker in PTC.•High expression of AHNAK2 correlated with worse clinical characteristics in PTC.•High expression... Papillary thyroid cancer (PTC) is the most prevalent endocrine tumor, and its incidence is still increasing. The mechanisms of PTC dedifferentiation and... |
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SubjectTerms | AHNAK2 Bioinformatic analysis Cancer Correlation analysis GEO Immune infiltration Immune system Infiltration Lymph nodes Lymphocytes Lymphocytes T Markers Metastases Papillary thyroid cancer Survival Survival analysis Thyroid Thyroid cancer |
Title | AHNAK2 is a novel prognostic marker and correlates with immune infiltration in papillary thyroid cancer: Evidence from integrated analysis |
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