Topical levamisole hydrochloride therapy attenuates experimental murine allergic rhinitis

• Published in: European journal of pharmacology Vol. 577; no. 1; pp. 162 - 169
• Main Authors: Wang, Heyao, Zhang, Jiali, Gao, Chunsheng, Zhu, Ying, Wang, Chen, Zheng, Wenjie
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 22.12.2007; Elsevier
• Subjects: Administration, Intranasal; Allergic rhinitis; Aluminum Hydroxide - pharmacology; Animals; Anti-Allergic Agents - administration & dosage; Anti-Allergic Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biological and medical sciences; Bordetella pertussis - immunology; Coloring Agents; Cytokines - metabolism; Enzyme-Linked Immunosorbent Assay; Eosinophil; Eosinophils - pathology; Histamine - analysis; Histamine Release - drug effects; Immunoglobulin E - analysis; Immunohistochemistry; Indicators and Reagents; Interleukin-12 - biosynthesis; Levamisole - administration & dosage; Levamisole - therapeutic use; Levamisole hydrochloride; Male; Medical sciences; Mice; Mice, Inbred BALB C; Mouse; Naphthalenesulfonates; Nasal Mucosa - pathology; Non tumoral diseases; Otorhinolaryngology. Stomatology; Ovalbumin - immunology; Pharmacology. Drug treatments; Reverse Transcriptase Polymerase Chain Reaction; Rhinitis, Allergic, Perennial - drug therapy; Rhinitis, Allergic, Perennial - pathology; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Mouse; Levamisole hydrochloride; Allergic rhinitis; Eosinophil; Immunopathology; Allergy; Nose disease; Anthelmintic; Rhinitis; Toxicity; Rodentia; Levamisole; Local administration; Vertebrata; Immunostimulant agent; Mammalia; Treatment; Animal; ENT disease; Parasiticide; Topical administration

Allergic rhinitis is one of the most common chronic diseases. There are a number of effective therapeutic options for allergic rhinitis patients, such as intranasal corticosteroids. How to avoid the adverse effects of these traditional medicines has come to public attention and started the search fo...