A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment - Thal, Leon J; Ferris, Steven H; Kirby, Louis; Block, Gilbert A; Lines, Christopher R; Yuen, Eric; Assaid, Christopher; Nessly, Michael L; Norman, Barbara A; Baranak, Christine C; Reines, Scott A (Neuropsychopharmacology (New York, N.Y.), 2005)
Keywords: Aged; Biological and medical sciences; Cognition Disorders - drug therapy; Cognition Disorders - psychology; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - therapeutic use; Dementia - psychology; Disease Progression; Double-Blind Method; Female; Humans; Lactones - therapeutic use; Male; Medical sciences; Membrane Proteins; Neuropharmacology; Neuropsychological Tests; Pharmacology. Drug treatments; Prostaglandin-Endoperoxide Synthases - metabolism; Psychiatric Status Rating Scales; Sulfones - therapeutic use; Human; nonsteroidal anti-inflammatory drugs; Prostaglandin-endoperoxide synthase; COX-2 inhibitors; Nervous system diseases; Rofecoxib; Cognitive disorder; Enzyme; Alzheimer disease; Enzyme inhibitor; Patient; Cyclooxygenase 2 inhibitor; Cerebral disorder; Non steroidal antiinflammatory agent; Randomization; Central nervous system disease; Double blind study; Degenerative disease; mild cognitive impairment; Oxidoreductases; Alzheimer's disease