The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges

• Published in: International journal of molecular sciences Vol. 24; no. 7; p. 6709
• Main Authors: Entsie, Philomena, Kang, Ying, Amoafo, Emmanuel Boadi, Schöneberg, Torsten, Liverani, Elisabetta
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 04.04.2023; MDPI
• Subjects: Blood clots; Cardiovascular disease; Dendritic cells; Immune system; Inflammatory diseases; Kinases; Lymphocytes; Neutrophils; Proteins; Review; Sepsis; Thrombosis

P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2...