The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges

P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2...

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Published inInternational journal of molecular sciences Vol. 24; no. 7; p. 6709
Main Authors Entsie, Philomena, Kang, Ying, Amoafo, Emmanuel Boadi, Schöneberg, Torsten, Liverani, Elisabetta
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 04.04.2023
MDPI
Subjects
Blood clots
Cardiovascular disease
Dendritic cells
Immune system
Inflammatory diseases
Kinases
Lymphocytes
Neutrophils
Proteins
Review
Sepsis
Thrombosis
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms24076709

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Abstract P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2Y12 is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. As a result, studies were carried out investigating whether therapies targeting P2Y12 could also ameliorate inflammatory conditions, such as sepsis, rheumatoid arthritis, neuroinflammation, cancer, COVID-19, atherosclerosis, and diabetes-associated inflammation in animal models and human subjects. This review reports what is known about the expression of P2Y12 in the cells of the immune system and the effect of P2Y12 activation and/or inhibition in inflammatory conditions. Lastly, we will discuss the major problems and challenges in studying this receptor and provide insights on how they can be overcome.
AbstractList P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2Y12 is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. As a result, studies were carried out investigating whether therapies targeting P2Y12 could also ameliorate inflammatory conditions, such as sepsis, rheumatoid arthritis, neuroinflammation, cancer, COVID-19, atherosclerosis, and diabetes-associated inflammation in animal models and human subjects. This review reports what is known about the expression of P2Y12 in the cells of the immune system and the effect of P2Y12 activation and/or inhibition in inflammatory conditions. Lastly, we will discuss the major problems and challenges in studying this receptor and provide insights on how they can be overcome.P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2Y12 is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. As a result, studies were carried out investigating whether therapies targeting P2Y12 could also ameliorate inflammatory conditions, such as sepsis, rheumatoid arthritis, neuroinflammation, cancer, COVID-19, atherosclerosis, and diabetes-associated inflammation in animal models and human subjects. This review reports what is known about the expression of P2Y12 in the cells of the immune system and the effect of P2Y12 activation and/or inhibition in inflammatory conditions. Lastly, we will discuss the major problems and challenges in studying this receptor and provide insights on how they can be overcome.
P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2Y12 is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. As a result, studies were carried out investigating whether therapies targeting P2Y12 could also ameliorate inflammatory conditions, such as sepsis, rheumatoid arthritis, neuroinflammation, cancer, COVID-19, atherosclerosis, and diabetes-associated inflammation in animal models and human subjects. This review reports what is known about the expression of P2Y12 in the cells of the immune system and the effect of P2Y12 activation and/or inhibition in inflammatory conditions. Lastly, we will discuss the major problems and challenges in studying this receptor and provide insights on how they can be overcome.
P2Y 12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y 12 has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2Y 12 is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. As a result, studies were carried out investigating whether therapies targeting P2Y 12 could also ameliorate inflammatory conditions, such as sepsis, rheumatoid arthritis, neuroinflammation, cancer, COVID-19, atherosclerosis, and diabetes-associated inflammation in animal models and human subjects. This review reports what is known about the expression of P2Y 12 in the cells of the immune system and the effect of P2Y 12 activation and/or inhibition in inflammatory conditions. Lastly, we will discuss the major problems and challenges in studying this receptor and provide insights on how they can be overcome.
Author Kang, Ying
Schöneberg, Torsten
Entsie, Philomena
Liverani, Elisabetta
Amoafo, Emmanuel Boadi
AuthorAffiliation 2 Division of Molecular Biochemistry, Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, 04103 Leipzig, Germany
1 Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA
AuthorAffiliation_xml – name: 2 Division of Molecular Biochemistry, Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, 04103 Leipzig, Germany
– name: 1 Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA
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  givenname: Philomena
  orcidid: 0000-0002-4858-8339
  surname: Entsie
  fullname: Entsie, Philomena
– sequence: 2
  givenname: Ying
  surname: Kang
  fullname: Kang, Ying
– sequence: 3
  givenname: Emmanuel Boadi
  surname: Amoafo
  fullname: Amoafo, Emmanuel Boadi
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  givenname: Torsten
  orcidid: 0000-0001-5313-0237
  surname: Schöneberg
  fullname: Schöneberg, Torsten
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  givenname: Elisabetta
  orcidid: 0000-0001-5540-0456
  surname: Liverani
  fullname: Liverani, Elisabetta
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Cites_doi 10.1016/j.celrep.2022.111369
10.3390/ijms21020678
10.3109/09537104.2013.809520
10.1371/journal.pone.0210821
10.1093/ehjcvp/pvz003
10.1002/iid3.697
10.4049/jimmunol.0901799
10.1159/000212098
10.1111/j.1538-7836.2010.04144.x
10.1161/ATVBAHA.110.213702
10.1016/j.ejphar.2022.174793
10.1164/rccm.201109-1712OC
10.1161/STROKEAHA.120.030616
10.1080/09537104.2019.1573314
10.1007/s00018-018-2937-2
10.1073/pnas.90.11.5297
10.1080/17512433.2022.2121702
10.1161/ATVBAHA.110.220467
10.1093/eurheartj/ehu075
10.1007/s11302-012-9303-x
10.1159/000491768
10.20944/preprints202003.0288.v1
10.1212/NXI.0000000000000080
10.1136/neurintsurg-2022-018986
10.3389/fimmu.2020.00940
10.3390/biomedicines10112862
10.1038/s41598-021-95710-3
10.1093/rheumatology/keab481
10.1016/j.molimm.2013.04.002
10.3389/fphar.2019.01008
10.1001/jamacardio.2021.1720
10.1161/CIRCULATIONAHA.118.038317
10.1136/heartjnl-2021-319552
10.3390/ijms20123111
10.1002/rth2.12344
10.3390/ijms22041636
10.3390/ijms21218177
10.1161/ATVBAHA.115.306528
10.1186/1471-2172-5-16
10.3389/fneur.2022.727026
10.1126/science.1181928
10.1016/j.mpmed.2010.08.007
10.1111/j.1538-7836.2006.02192.x
10.1016/j.atherosclerosis.2018.05.053
10.1111/jcmm.14239
10.1001/jama.2016.0287
10.3390/ijms21041391
10.1111/jcmm.12727
10.1038/s41423-020-0444-5
10.1016/j.jaut.2019.102400
10.3109/09537104.2012.670812
10.1007/s10557-022-07373-5
10.3389/fphar.2018.00066
10.1016/j.ahj.2021.03.009
10.1016/j.immuni.2019.06.025
10.1172/JCI12242
10.1161/JAHA.119.014457
10.1038/s41419-019-2010-6
10.1021/acsptsci.0c00016
10.1016/j.bbamcr.2006.12.001
10.1161/JAHA.119.014000
10.3109/09537104.2015.1069809
10.1016/S0140-6736(17)31472-1
10.1161/CIRCULATIONAHA.109.919456
10.1007/978-1-59745-553-4_17
10.3389/fimmu.2021.674189
10.1172/JCI12818
10.1124/mol.64.1.104
10.1161/STROKEAHA.117.019166
10.1007/s00380-015-0696-7
10.1161/ATVBAHA.116.308725
10.1186/s40035-020-00221-2
10.1074/jbc.M111.289793
10.1007/s11239-006-9033-4
10.1038/s41467-020-19737-2
10.1160/TH11-12-0876
10.1111/j.1538-7836.2011.04217.x
10.1161/01.ATV.0000142376.30582.ed
10.1002/clc.23653
10.1161/CIRCULATIONAHA.116.026995
10.2741/1939
10.1002/glia.22744
10.1002/glia.20489
10.1002/eji.201848013
10.1055/s-0041-1733857
10.1101/gad.314617.118
10.1161/01.ATV.20.11.e101
10.1161/CIRCULATIONAHA.117.031164
10.1001/jama.2022.2910
10.1016/j.bbi.2016.12.001
10.1016/S0140-6736(13)61451-8
10.1084/jem.20091240
10.1161/CIRCRESAHA.120.317703
10.1007/s10557-021-07202-1
10.1038/s41577-020-0308-3
10.1007/s12035-021-02676-4
10.1016/j.atherosclerosis.2015.04.015
10.1016/j.bcp.2021.114822
10.1371/journal.pone.0225771
10.1152/physrev.00021.2020
10.1161/CIRCULATIONAHA.109.921502
10.1097/PPO.0000000000000118
10.1111/j.1538-7836.2004.00741.x
10.7554/eLife.81890
10.1038/s41569-020-00469-1
10.1371/journal.pone.0010130
10.1007/5584_2017_91
10.1161/CIRCULATIONAHA.107.715821
10.3390/jpm8010008
10.1002/rth2.12709
10.1189/jlb.1012518
10.1016/j.jaccao.2020.04.009
10.1073/pnas.0510446103
10.1182/blood-2003-11-3840
10.1097/TP.0b013e318221d407
10.1016/j.cpcardiol.2022.101292
10.3174/ajnr.A7430
10.3389/fphar.2019.01558
10.1038/s41583-018-0057-5
10.3390/ijerph19158977
10.1161/CIRCRESAHA.118.313591
10.1161/ATVBAHA.111.239095
10.4049/jimmunol.178.3.1628
10.1073/pnas.1520398113
10.1186/s12933-018-0783-z
10.1111/j.1538-7836.2008.03039.x
10.1016/j.jacc.2014.09.017
10.1080/09537104.2018.1457781
10.1111/bph.14218
10.1161/01.ATV.19.10.2281
10.1371/journal.pone.0139805
10.1182/blood.V98.12.3340
10.1016/j.cub.2020.06.081
10.1016/j.jaci.2017.05.011
10.1097/SHK.0b013e3181f48987
10.1007/s11302-022-09876-0
10.3390/ijms21062111
10.1111/jnc.13968
10.1210/jc.2004-0137
10.3109/09537104.2010.497231
10.1016/j.neuropharm.2015.10.030
10.1097/CCM.0b013e31819ceb71
10.1161/01.ATV.0000012805.49079.23
10.1124/jpet.112.195883
10.1002/JLB.3A0220-097R
10.3892/etm.2021.9906
10.1172/JCI38576
10.1016/j.ejim.2022.11.027
10.1371/journal.pone.0026035
10.1111/j.1538-7836.2005.01325.x
10.1007/s00418-011-0859-2
10.1161/01.RES.0000153670.07559.E4
10.1161/ATVBAHA.116.307401
10.3389/fphar.2022.952211
10.3389/fphar.2020.00301
10.4049/jimmunol.1601549
10.1111/j.1538-7836.2008.03020.x
10.3389/fmed.2017.00129
10.1371/journal.pone.0069093
10.15420/ecr.2018.33.1
10.1161/01.RES.88.4.438
10.1007/s12079-019-00540-8
10.1161/01.CIR.0000016703.93845.AF
10.1182/blood-2014-05-576306
10.1016/j.jacbts.2018.05.005
10.1186/s12974-019-1603-4
10.1002/clc.23536
10.1007/s10585-018-9874-1
10.1182/blood-2004-07-2893
10.1161/ATVBAHA.115.305655
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References Lee (ref_169) 2012; 23
ref_91
Calebiro (ref_97) 2021; 101
Ortega (ref_99) 2017; 1051
Abusnina (ref_107) 2022; 47
Zhang (ref_109) 2023; 18
Liverani (ref_12) 2016; 36
Quinton (ref_21) 2004; 2
Fujisaki (ref_172) 2021; 237
Mansour (ref_160) 2022; 918
Gao (ref_116) 2019; 76
Liverani (ref_103) 2014; 95
Aronoff (ref_51) 2007; 178
Wright (ref_128) 2020; 2
Zhou (ref_10) 2019; 30
ref_15
Butovsky (ref_61) 2018; 19
Huang (ref_83) 2021; 18
Wiviott (ref_76) 2013; 382
Reineri (ref_167) 2007; 1773
Zaid (ref_147) 2020; 127
ref_129
Santana (ref_140) 2020; 11
Magro (ref_89) 2022; 13
Savi (ref_22) 2006; 103
ref_121
Foster (ref_40) 2001; 107
Shanker (ref_113) 2006; 22
Ye (ref_162) 2015; 35
Yu (ref_63) 2022; 13
Schreuder (ref_155) 2020; 9
Heim (ref_111) 2016; 31
Anderson (ref_124) 2020; 30
Yang (ref_139) 2017; 140
Han (ref_67) 2022; 10
Cammarata (ref_4) 2010; 185
Garshick (ref_120) 2021; 60
Harada (ref_50) 2011; 92
Jantzen (ref_19) 2001; 108
Lam (ref_78) 2021; 44
Lou (ref_17) 2016; 113
ref_70
Nagy (ref_27) 2011; 9
Siegel (ref_43) 2021; 11
Hsiao (ref_60) 2021; 12
Gachet (ref_39) 2012; 8
Goth (ref_96) 2020; 3
Amsterdam (ref_80) 2014; 64
ref_79
Kwon (ref_152) 2020; 9
Rabouel (ref_104) 2021; 5
Yu (ref_163) 2021; 21
ref_157
Capranzano (ref_173) 2019; 8
ref_73
Niu (ref_115) 2017; 37
Zuo (ref_138) 2013; 56
Hu (ref_86) 2017; 136
Husted (ref_156) 2014; 35
Waissi (ref_158) 2020; 4
McInnes (ref_118) 2017; 389
Badolia (ref_85) 2015; 125
Rahman (ref_161) 2014; 25
Liverani (ref_5) 2013; 344
Miyata (ref_41) 2017; 141
Gelbenegger (ref_72) 2022; 15
Murugappa (ref_1) 2006; 11
Micklewright (ref_6) 2018; 175
Kim (ref_20) 2011; 22
Feldman (ref_52) 2022; 11
Kuszynski (ref_74) 2022; 18
Cao (ref_145) 2020; 20
Su (ref_16) 2012; 122
Isfort (ref_46) 2011; 286
Khalaji (ref_151) 2022; 110
Wu (ref_23) 1993; 90
ref_84
Suzuki (ref_62) 2020; 50
Asaduzzaman (ref_102) 2009; 37
Alves (ref_53) 2019; 10
Matsuno (ref_135) 2005; 90
Cattaneo (ref_34) 1999; 19
Zhang (ref_18) 2017; 62
Trinh (ref_14) 2019; 23
Loskog (ref_123) 2020; 11
Greten (ref_125) 2019; 51
Marteau (ref_100) 2003; 64
Preissler (ref_59) 2015; 63
Li (ref_112) 2012; 32
Hottz (ref_148) 2022; 6
Liu (ref_94) 2011; 31
ref_57
Boilard (ref_119) 2010; 327
Kloss (ref_45) 2019; 10
ref_55
Schwarcz (ref_56) 2022; 40
ref_54
Hackert (ref_95) 2009; 9
Wolf (ref_106) 2019; 124
Thomas (ref_37) 2015; 35
Judge (ref_87) 2016; 27
Gu (ref_146) 2021; 18
Maccioni (ref_153) 2019; 10
Schedel (ref_38) 2009; 496
Albayati (ref_11) 2021; 110
Kaufmann (ref_131) 2019; 5
Mundell (ref_24) 2008; 6
Moro (ref_165) 2005; 105
Gonzalez (ref_126) 2018; 32
Morel (ref_28) 2012; 108
Franchi (ref_92) 2019; 139
Hoffmann (ref_98) 2016; 104
Santoro (ref_149) 2022; 108
Mendolicchio (ref_33) 2010; 9
Cattaneo (ref_35) 2000; 20
Hardy (ref_25) 2005; 105
Wiviott (ref_75) 2010; 122
Nealen (ref_166) 2001; 88
Johansson (ref_142) 2012; 185
Dovlatova (ref_90) 2008; 6
Vemulapalli (ref_7) 2020; 14
Quinton (ref_26) 2005; 3
Chen (ref_82) 2021; 44
ref_168
Wongsalap (ref_77) 2022; 36
Hagiwara (ref_93) 2011; 35
Ngo (ref_170) 2020; 31
Ballerini (ref_127) 2018; 9
Kahner (ref_2) 2006; 4
Li (ref_171) 2008; 117
Olah (ref_58) 2020; 11
Rauch (ref_114) 2010; 30
Forouhi (ref_132) 2010; 38
Moore (ref_44) 2015; 2
Xu (ref_136) 2022; 59
ref_32
Goto (ref_30) 2002; 105
Remijn (ref_29) 2002; 22
Qin (ref_48) 2017; 199
Marnat (ref_88) 2022; 43
Bhavaraju (ref_69) 2010; 13
Gurbel (ref_81) 2010; 121
Wang (ref_101) 2005; 96
Turner (ref_31) 2001; 98
Wihlborg (ref_65) 2004; 24
Tsalamandris (ref_133) 2019; 14
Singer (ref_108) 2016; 315
Gareau (ref_130) 2018; 35
Angiolillo (ref_71) 2017; 136
LeBleu (ref_122) 2015; 21
Bradbury (ref_150) 2022; 327
ref_105
Uehara (ref_66) 2011; 136
ref_47
Gao (ref_164) 2018; 48
Scherer (ref_117) 2020; 110
Pretorius (ref_134) 2018; 17
Zaccardi (ref_137) 2015; 240
Suh (ref_13) 2016; 20
ref_3
Malhotra (ref_68) 2018; 49
ref_49
Jing (ref_64) 2019; 16
ref_9
ref_8
Ohsawa (ref_42) 2007; 55
Vogel (ref_154) 2021; 6
Shah (ref_36) 2017; 4
Waissi (ref_159) 2020; 51
Paruchuri (ref_141) 2009; 206
Zhong (ref_144) 2021; 194
Ganbaatar (ref_110) 2018; 275
Sexton (ref_143) 2018; 3
References_xml – volume: 40
  start-page: 111369
  year: 2022
  ident: ref_56
  article-title: Microglial control of neuronal development via somatic purinergic junctions
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2022.111369
– ident: ref_54
  doi: 10.3390/ijms21020678
– volume: 25
  start-page: 257
  year: 2014
  ident: ref_161
  article-title: Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis
  publication-title: Platelets
  doi: 10.3109/09537104.2013.809520
– ident: ref_79
  doi: 10.1371/journal.pone.0210821
– volume: 5
  start-page: 100
  year: 2019
  ident: ref_131
  article-title: Is P2Y12 inhibitor therapy associated with an increased risk of cancer?
  publication-title: Eur. Heart J.—Cardiovasc. Pharmacother.
  doi: 10.1093/ehjcvp/pvz003
– volume: 10
  start-page: e697
  year: 2022
  ident: ref_67
  article-title: Inhibiting P2Y12 receptor relieves LPS-induced inflammation and endothelial dysfunction
  publication-title: Immun. Inflamm. Dis.
  doi: 10.1002/iid3.697
– volume: 185
  start-page: 5900
  year: 2010
  ident: ref_4
  article-title: Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901799
– volume: 9
  start-page: 369
  year: 2009
  ident: ref_95
  article-title: P-Selectin Inhibition Reduces Severity of Acute Experimental Pancreatitis
  publication-title: Pancreatology
  doi: 10.1159/000212098
– volume: 9
  start-page: 373
  year: 2010
  ident: ref_33
  article-title: Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2010.04144.x
– volume: 30
  start-page: 2434
  year: 2010
  ident: ref_114
  article-title: Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.110.213702
– volume: 918
  start-page: 174793
  year: 2022
  ident: ref_160
  article-title: Repositioning of Ticagrelor: Renoprotection mediated by modulating renin-angiotensin system, inflammation, autophagy and galectin-3
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2022.174793
– volume: 185
  start-page: 498
  year: 2012
  ident: ref_142
  article-title: Platelet Activation, P-Selectin, and Eosinophil β1-Integrin Activation in Asthma
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201109-1712OC
– volume: 51
  start-page: 2972
  year: 2020
  ident: ref_159
  article-title: Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.120.030616
– volume: 31
  start-page: 68
  year: 2020
  ident: ref_170
  article-title: Assessment of neonatal, cord, and adult platelet granule trafficking and secretion
  publication-title: Platelets
  doi: 10.1080/09537104.2019.1573314
– volume: 76
  start-page: 341
  year: 2019
  ident: ref_116
  article-title: The role of P2Y12 receptor in ischemic stroke of atherosclerotic origin
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-018-2937-2
– volume: 90
  start-page: 5297
  year: 1993
  ident: ref_23
  article-title: Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.90.11.5297
– volume: 15
  start-page: 1177
  year: 2022
  ident: ref_72
  article-title: Clinical pharmacology of antiplatelet drugs
  publication-title: Expert Rev. Clin. Pharmacol.
  doi: 10.1080/17512433.2022.2121702
– volume: 31
  start-page: 834
  year: 2011
  ident: ref_94
  article-title: Novel Role of Platelets in Mediating Inflammatory Responses and Ventricular Rupture or Remodeling Following Myocardial Infarction
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.110.220467
– volume: 35
  start-page: 1541
  year: 2014
  ident: ref_156
  article-title: The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient Outcomes (PLATO) trial
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehu075
– volume: 8
  start-page: 609
  year: 2012
  ident: ref_39
  article-title: P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells
  publication-title: Purinergic Signal.
  doi: 10.1007/s11302-012-9303-x
– volume: 48
  start-page: 385
  year: 2018
  ident: ref_164
  article-title: Comparison of the Effects of Ticagrelor and Clopidogrel on Inflammatory Factors, Vascular Endothelium Functions and Short-Term Prognosis in Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention: A Pilot Study
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000491768
– ident: ref_57
  doi: 10.20944/preprints202003.0288.v1
– volume: 2
  start-page: e80
  year: 2015
  ident: ref_44
  article-title: P2Y12 expression and function in alternatively activated human microglia
  publication-title: Neurol. Neuroimmunol. Neuroinflamm.
  doi: 10.1212/NXI.0000000000000080
– ident: ref_91
  doi: 10.1136/neurintsurg-2022-018986
– volume: 11
  start-page: 940
  year: 2020
  ident: ref_123
  article-title: The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.00940
– ident: ref_49
  doi: 10.3390/biomedicines10112862
– volume: 11
  start-page: 17459
  year: 2021
  ident: ref_43
  article-title: P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-95710-3
– volume: 60
  start-page: 5473
  year: 2021
  ident: ref_120
  article-title: Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/keab481
– volume: 56
  start-page: 57
  year: 2013
  ident: ref_138
  article-title: Molecular mechanisms of reactive oxygen species-related pulmonary inflammation and asthma
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2013.04.002
– volume: 10
  start-page: 1008
  year: 2019
  ident: ref_153
  article-title: Neuroinflammation as a Common Feature of Neurodegenerative Disorders
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2019.01008
– volume: 6
  start-page: 1032
  year: 2021
  ident: ref_154
  article-title: Sex Differences among Patients with High Risk Receiving Ticagrelor with or without Aspirin after Percutaneous Coronary Intervention: A Subgroup Analysis of the TWILIGHT Randomized Clinical Trial
  publication-title: JAMA Cardiol.
  doi: 10.1001/jamacardio.2021.1720
– volume: 139
  start-page: 1661
  year: 2019
  ident: ref_92
  article-title: Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.118.038317
– volume: 108
  start-page: 130
  year: 2022
  ident: ref_149
  article-title: Antiplatelet therapy and outcome in COVID-19: The Health Outcome Predictive Evaluation Registry
  publication-title: Heart
  doi: 10.1136/heartjnl-2021-319552
– ident: ref_168
  doi: 10.3390/ijms20123111
– volume: 4
  start-page: 879
  year: 2020
  ident: ref_158
  article-title: Sex differences in flow cytometry–based platelet reactivity in stable outpatients suspected of myocardial ischemia
  publication-title: Res. Pract. Thromb. Haemost.
  doi: 10.1002/rth2.12344
– ident: ref_3
  doi: 10.3390/ijms22041636
– ident: ref_9
  doi: 10.3390/ijms21218177
– volume: 35
  start-page: 2562
  year: 2015
  ident: ref_37
  article-title: Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.115.306528
– ident: ref_8
  doi: 10.1186/1471-2172-5-16
– volume: 13
  start-page: 727026
  year: 2022
  ident: ref_89
  article-title: Safety and Efficacy of Cangrelor among Three Antiplatelet Regimens during Stent-Assisted Endovascular Treatment of Unruptured Intracranial Aneurysm: A Single-Center Retrospective Study
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2022.727026
– volume: 327
  start-page: 580
  year: 2010
  ident: ref_119
  article-title: Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
  publication-title: Science
  doi: 10.1126/science.1181928
– volume: 38
  start-page: 602
  year: 2010
  ident: ref_132
  article-title: Epidemiology of diabetes
  publication-title: Medicine
  doi: 10.1016/j.mpmed.2010.08.007
– volume: 4
  start-page: 2317
  year: 2006
  ident: ref_2
  article-title: Nucleotide receptor signaling in platelets
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2006.02192.x
– volume: 275
  start-page: 124
  year: 2018
  ident: ref_110
  article-title: Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2018.05.053
– volume: 23
  start-page: 3441
  year: 2019
  ident: ref_14
  article-title: The synergistic effects of clopidogrel with montelukast may be beneficial for asthma treatment
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/jcmm.14239
– volume: 315
  start-page: 801
  year: 2016
  ident: ref_108
  article-title: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
  publication-title: JAMA
  doi: 10.1001/jama.2016.0287
– ident: ref_129
  doi: 10.3390/ijms21041391
– volume: 20
  start-page: 333
  year: 2016
  ident: ref_13
  article-title: P2Y12 antagonist attenuates eosinophilic inflammation and airway hyperresponsiveness in a mouse model of asthma
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/jcmm.12727
– volume: 18
  start-page: 1278
  year: 2021
  ident: ref_83
  article-title: Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway
  publication-title: Cell. Mol. Immunol.
  doi: 10.1038/s41423-020-0444-5
– volume: 110
  start-page: 102400
  year: 2020
  ident: ref_117
  article-title: The etiology of rheumatoid arthritis
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2019.102400
– volume: 23
  start-page: 579
  year: 2012
  ident: ref_169
  article-title: Effects of testosterone and 17β-oestradiol on expression of the G protein-coupled receptor P2Y12 in megakaryocytic DAMI cells
  publication-title: Platelets
  doi: 10.3109/09537104.2012.670812
– ident: ref_84
  doi: 10.1007/s10557-022-07373-5
– volume: 9
  start-page: 66
  year: 2018
  ident: ref_127
  article-title: P2Y12 Receptors in Tumorigenesis and Metastasis
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2018.00066
– volume: 237
  start-page: 34
  year: 2021
  ident: ref_172
  article-title: Potent P2Y12 inhibitors versus Clopidogrel in elderly patients with acute coronary syndrome: Systematic review and meta-analysis
  publication-title: Am. Heart J.
  doi: 10.1016/j.ahj.2021.03.009
– volume: 51
  start-page: 27
  year: 2019
  ident: ref_125
  article-title: Inflammation and Cancer: Triggers, Mechanisms, and Consequences
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.06.025
– volume: 107
  start-page: 1591
  year: 2001
  ident: ref_40
  article-title: Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI12242
– volume: 9
  start-page: e014457
  year: 2020
  ident: ref_155
  article-title: Efficacy and Safety of High Potent P2Y12 Inhibitors Prasugrel and Ticagrelor in Patients with Coronary Heart Disease Treated with Dual Antiplatelet Therapy: A Sex-Specific Systematic Review and Meta-Analysis
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.119.014457
– volume: 10
  start-page: 760
  year: 2019
  ident: ref_45
  article-title: ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-2010-6
– volume: 3
  start-page: 237
  year: 2020
  ident: ref_96
  article-title: G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications
  publication-title: ACS Pharmacol. Transl. Sci.
  doi: 10.1021/acsptsci.0c00016
– volume: 1773
  start-page: 273
  year: 2007
  ident: ref_167
  article-title: Membrane lipid rafts coordinate estrogen-dependent signaling in human platelets
  publication-title: Biochim. Biophys. Acta (BBA)-Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2006.12.001
– volume: 8
  start-page: e014000
  year: 2019
  ident: ref_173
  article-title: Tailoring P2Y12 Inhibiting Therapy in Elderly Patients with Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.119.014000
– volume: 27
  start-page: 191
  year: 2016
  ident: ref_87
  article-title: Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y12 receptors in vitro
  publication-title: Platelets
  doi: 10.3109/09537104.2015.1069809
– volume: 389
  start-page: 2328
  year: 2017
  ident: ref_118
  article-title: Pathogenetic insights from the treatment of rheumatoid arthritis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31472-1
– volume: 121
  start-page: 1188
  year: 2010
  ident: ref_81
  article-title: Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies: The RESPOND study
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.109.919456
– volume: 496
  start-page: 273
  year: 2009
  ident: ref_38
  article-title: Genome-Wide Platelet RNA Profiling in Clinical Samples
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-59745-553-4_17
– volume: 12
  start-page: 674189
  year: 2021
  ident: ref_60
  article-title: GPCRomics of Homeostatic and Disease-Associated Human Microglia
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.674189
– volume: 108
  start-page: 477
  year: 2001
  ident: ref_19
  article-title: Impaired activation of murine platelets lacking G alpha(i2)
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI12818
– volume: 64
  start-page: 104
  year: 2003
  ident: ref_100
  article-title: Pharmacological Characterization of the Human P2Y13 Receptor
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.64.1.104
– volume: 49
  start-page: 312
  year: 2018
  ident: ref_68
  article-title: Cerebrovascular Outcomes with Proton Pump Inhibitors and Thienopyridines: A Systematic Review and Meta-Analysis
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.117.019166
– volume: 31
  start-page: 783
  year: 2016
  ident: ref_111
  article-title: Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo
  publication-title: Heart Vessel.
  doi: 10.1007/s00380-015-0696-7
– volume: 37
  start-page: 515
  year: 2017
  ident: ref_115
  article-title: P2Y12 Promotes Migration of Vascular Smooth Muscle Cells Through Cofilin Dephosphorylation During Atherogenesis
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.308725
– volume: 9
  start-page: 42
  year: 2020
  ident: ref_152
  article-title: Neuroinflammation in neurodegenerative disorders: The roles of microglia and astrocytes
  publication-title: Transl. Neurodegener.
  doi: 10.1186/s40035-020-00221-2
– volume: 286
  start-page: 44776
  year: 2011
  ident: ref_46
  article-title: Real-time Imaging Reveals That P2Y2 and P2Y12 Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.289793
– volume: 22
  start-page: 213
  year: 2006
  ident: ref_113
  article-title: Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts
  publication-title: J. Thromb. Thrombolysis
  doi: 10.1007/s11239-006-9033-4
– volume: 11
  start-page: 6129
  year: 2020
  ident: ref_58
  article-title: Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19737-2
– volume: 108
  start-page: 338
  year: 2012
  ident: ref_28
  article-title: The extent of P2Y12 inhibition by clopidogrel in diabetes mellitus patients with acute coronary syndrome is not related to glycaemic control: Roles of white blood cell count and body weight
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH11-12-0876
– volume: 18
  start-page: 270
  year: 2023
  ident: ref_109
  article-title: Comparison of aspirin and P2Y12 inhibitors for secondary prevention of ischaemic stroke: A systematic review and meta-analysis
  publication-title: Curr. Clin. Pharmacol.
– volume: 9
  start-page: 810
  year: 2011
  ident: ref_27
  article-title: Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2011.04217.x
– volume: 13
  start-page: 497
  year: 2010
  ident: ref_69
  article-title: P2Y(12) antagonists as antiplatelet agents-Recent developments
  publication-title: Curr. Opin. Drug Discov. Dev.
– volume: 24
  start-page: 1810
  year: 2004
  ident: ref_65
  article-title: ADP Receptor P2Y12 Is Expressed in Vascular Smooth Muscle Cells and Stimulates Contraction in Human Blood Vessels
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000142376.30582.ed
– volume: 44
  start-page: 1072
  year: 2021
  ident: ref_78
  article-title: Efficacy and safety comparing prasugrel/ticagrelor and clopidogrel in Hong Kong post-acute coronary syndrome patients–A 10-year cohort study
  publication-title: Clin. Cardiol.
  doi: 10.1002/clc.23653
– volume: 136
  start-page: 817
  year: 2017
  ident: ref_86
  article-title: Platelets Express Activated P2Y12 Receptor in Patients with Diabetes Mellitus
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.026995
– volume: 11
  start-page: 1977
  year: 2006
  ident: ref_1
  article-title: The role of ADP receptors in platelet function
  publication-title: Front. Biosci.
  doi: 10.2741/1939
– volume: 63
  start-page: 206
  year: 2015
  ident: ref_59
  article-title: Altered microglial phagocytosis in GPR34-deficient mice
  publication-title: Glia
  doi: 10.1002/glia.22744
– volume: 55
  start-page: 604
  year: 2007
  ident: ref_42
  article-title: Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis
  publication-title: Glia
  doi: 10.1002/glia.20489
– volume: 50
  start-page: 205
  year: 2020
  ident: ref_62
  article-title: Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201848013
– volume: 5
  start-page: e343
  year: 2021
  ident: ref_104
  article-title: Platelet P2Y12 Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock
  publication-title: TH Open
  doi: 10.1055/s-0041-1733857
– volume: 32
  start-page: 1267
  year: 2018
  ident: ref_126
  article-title: Roles of the immune system in cancer: From tumor initiation to metastatic progression
  publication-title: Genes Dev.
  doi: 10.1101/gad.314617.118
– volume: 20
  start-page: E101
  year: 2000
  ident: ref_35
  article-title: Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet ‘primary secretion defect’ are heterozygous for a defect of P2CYC receptors
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.20.11.e101
– volume: 136
  start-page: 1955
  year: 2017
  ident: ref_71
  article-title: International Expert Consensus on Switching Platelet P2Y12 Receptor–Inhibiting Therapies
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.117.031164
– volume: 327
  start-page: 1247
  year: 2022
  ident: ref_150
  article-title: Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients with COVID-19: A Randomized Clinical Trial
  publication-title: JAMA J. Am. Med. Assoc.
  doi: 10.1001/jama.2022.2910
– volume: 62
  start-page: 245
  year: 2017
  ident: ref_18
  article-title: Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2016.12.001
– volume: 382
  start-page: 605
  year: 2013
  ident: ref_76
  article-title: Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: A secondary, prespecified analysis of the TRILOGY ACS trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)61451-8
– volume: 206
  start-page: 2543
  year: 2009
  ident: ref_141
  article-title: Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20091240
– volume: 127
  start-page: 1404
  year: 2020
  ident: ref_147
  article-title: Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.120.317703
– volume: 36
  start-page: 991
  year: 2022
  ident: ref_77
  article-title: Efficacy and Safety of Low-Dose Prasugrel Versus Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis
  publication-title: Cardiovasc. Drugs Ther.
  doi: 10.1007/s10557-021-07202-1
– volume: 20
  start-page: 269
  year: 2020
  ident: ref_145
  article-title: COVID-19: Immunopathology and its implications for therapy
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-020-0308-3
– volume: 59
  start-page: 1604
  year: 2022
  ident: ref_136
  article-title: Study of the Involvement of the P2Y12 Receptor in Chronic Itching in Type 2 Diabetes Mellitus
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-021-02676-4
– volume: 240
  start-page: 439
  year: 2015
  ident: ref_137
  article-title: Efficacy and safety of P2Y12 inhibitors according to diabetes, age, gender, body mass index and body weight: Systematic review and meta-analyses of randomized clinical trials
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2015.04.015
– volume: 194
  start-page: 114822
  year: 2021
  ident: ref_144
  article-title: NOD2-mediated P2Y12 upregulation increases platelet activation and thrombosis in sepsis
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2021.114822
– ident: ref_157
  doi: 10.1371/journal.pone.0225771
– volume: 101
  start-page: 857
  year: 2021
  ident: ref_97
  article-title: G protein-coupled receptor-G protein interactions: A single-molecule perspective
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00021.2020
– volume: 122
  start-page: 394
  year: 2010
  ident: ref_75
  article-title: Prasugrel
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.109.921502
– volume: 21
  start-page: 174
  year: 2015
  ident: ref_122
  article-title: Imaging the Tumor Microenvironment
  publication-title: Cancer J.
  doi: 10.1097/PPO.0000000000000118
– volume: 2
  start-page: 978
  year: 2004
  ident: ref_21
  article-title: Different G protein-coupled signaling pathways are involved in α granule release from human platelets
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2004.00741.x
– volume: 11
  start-page: e81890
  year: 2022
  ident: ref_52
  article-title: Microglia orchestrate neuroinflammation
  publication-title: Elife
  doi: 10.7554/eLife.81890
– volume: 18
  start-page: 194
  year: 2021
  ident: ref_146
  article-title: Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-020-00469-1
– ident: ref_32
  doi: 10.1371/journal.pone.0010130
– volume: 1051
  start-page: 139
  year: 2017
  ident: ref_99
  article-title: An Update on P2Y13 Receptor Signalling and Function
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/5584_2017_91
– volume: 117
  start-page: 553
  year: 2008
  ident: ref_171
  article-title: Dosing of Clopidogrel for Platelet Inhibition in Infants and Young Children: Primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.715821
– ident: ref_73
  doi: 10.3390/jpm8010008
– volume: 6
  start-page: e12709
  year: 2022
  ident: ref_148
  article-title: Platelet-leukocyte interactions in COVID-19: Contributions to hypercoagulability, inflammation, and disease severity
  publication-title: Res. Pract. Thromb. Haemost.
  doi: 10.1002/rth2.12709
– volume: 95
  start-page: 313
  year: 2014
  ident: ref_103
  article-title: LPS-induced systemic inflammation is more severe in P2Y12 null mice
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1012518
– volume: 2
  start-page: 236
  year: 2020
  ident: ref_128
  article-title: The TICONC (Ticagrelor-Oncology) Study: Implications of P2Y12 Inhibition for Metastasis and Cancer-Associated Thrombosis
  publication-title: JACC Cardio Oncol.
  doi: 10.1016/j.jaccao.2020.04.009
– volume: 103
  start-page: 11069
  year: 2006
  ident: ref_22
  article-title: The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0510446103
– volume: 105
  start-page: 115
  year: 2005
  ident: ref_165
  article-title: Nongenomic effects of 17β-estradiol in human platelets: Potentiation of thrombin-induced aggregation through estrogen receptor β and Src kinase
  publication-title: Blood
  doi: 10.1182/blood-2003-11-3840
– volume: 92
  start-page: 148
  year: 2011
  ident: ref_50
  article-title: Adenosine Diphosphate Receptor P2Y12-Mediated Migration of Host Smooth Muscle-Like Cells and Leukocytes in the Development of Transplant Arteriosclerosis
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e318221d407
– volume: 47
  start-page: 101292
  year: 2022
  ident: ref_107
  article-title: P2Y12 Inhibitors versus Aspirin Monotherapy for Long-term Secondary Prevention of Atherosclerotic Cardiovascular Disease Events: A Systematic Review and Meta-analysis
  publication-title: Curr. Probl. Cardiol.
  doi: 10.1016/j.cpcardiol.2022.101292
– volume: 43
  start-page: 410
  year: 2022
  ident: ref_88
  article-title: Safety and Efficacy of Cangrelor in Acute Stroke Treated with Mechanical Thrombectomy: Endovascular Treatment of Ischemic Stroke Registry and Meta-analysis
  publication-title: AJNR Am. J. Neuroradiol.
  doi: 10.3174/ajnr.A7430
– volume: 10
  start-page: 1558
  year: 2019
  ident: ref_53
  article-title: Differential Expression of the Metabotropic P2Y Receptor Family in the Cortex Following Status Epilepticus and Neuroprotection via P2Y1 Antagonism in Mice
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2019.01558
– volume: 19
  start-page: 622
  year: 2018
  ident: ref_61
  article-title: Microglial signatures and their role in health and disease
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/s41583-018-0057-5
– ident: ref_70
  doi: 10.3390/ijerph19158977
– volume: 124
  start-page: 315
  year: 2019
  ident: ref_106
  article-title: Immunity and Inflammation in Atherosclerosis
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.313591
– volume: 32
  start-page: e81
  year: 2012
  ident: ref_112
  article-title: Roles of Purinergic Receptor P2Y, G Protein–Coupled 12 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.111.239095
– volume: 178
  start-page: 1628
  year: 2007
  ident: ref_51
  article-title: Synthetic Prostacyclin Analogs Differentially Regulate Macrophage Function via Distinct Analog-Receptor Binding Specificities
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.178.3.1628
– volume: 113
  start-page: 1074
  year: 2016
  ident: ref_17
  article-title: Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1520398113
– volume: 17
  start-page: 141
  year: 2018
  ident: ref_134
  article-title: Platelet activity and hypercoagulation in type 2 diabetes
  publication-title: Cardiovasc. Diabetol.
  doi: 10.1186/s12933-018-0783-z
– volume: 6
  start-page: 1393
  year: 2008
  ident: ref_24
  article-title: Rapid resensitization of purinergic receptor function in human platelets
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2008.03039.x
– volume: 64
  start-page: e139
  year: 2014
  ident: ref_80
  article-title: 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2014.09.017
– volume: 30
  start-page: 452
  year: 2019
  ident: ref_10
  article-title: Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model
  publication-title: Platelets
  doi: 10.1080/09537104.2018.1457781
– volume: 175
  start-page: 2483
  year: 2018
  ident: ref_6
  article-title: P2Y12 receptor modulation of ADP-evoked intracellular Ca2+ signalling in THP-1 human monocytic cells
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.14218
– volume: 19
  start-page: 2281
  year: 1999
  ident: ref_34
  article-title: ADP Receptors and Clinical Bleeding Disorders
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.19.10.2281
– ident: ref_47
  doi: 10.1371/journal.pone.0139805
– volume: 98
  start-page: 3340
  year: 2001
  ident: ref_31
  article-title: Blockade of adenosine diphosphate receptors P2Y12 and P2Y1 is required to inhibit platelet aggregation in whole blood under flow
  publication-title: Blood
  doi: 10.1182/blood.V98.12.3340
– volume: 30
  start-page: R921
  year: 2020
  ident: ref_124
  article-title: The tumor microenvironment
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2020.06.081
– volume: 140
  start-page: 14
  year: 2017
  ident: ref_139
  article-title: The environment, epigenome, and asthma
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2017.05.011
– volume: 35
  start-page: 289
  year: 2011
  ident: ref_93
  article-title: Adenosine Diphosphate Receptor Antagonist Clopidogrel Sulfate Attenuates LPS-Induced Systemic Inflammation in a Rat Model
  publication-title: Shock
  doi: 10.1097/SHK.0b013e3181f48987
– volume: 18
  start-page: 253
  year: 2022
  ident: ref_74
  article-title: Pleiotropic effects of clopidogrel
  publication-title: Purinergic Signal.
  doi: 10.1007/s11302-022-09876-0
– ident: ref_55
  doi: 10.3390/ijms21062111
– volume: 141
  start-page: 100
  year: 2017
  ident: ref_41
  article-title: P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C-C chemokine 3 expression
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.13968
– volume: 90
  start-page: 920
  year: 2005
  ident: ref_135
  article-title: P2Y12 Receptors Play a Significant Role in the Development of Platelet Microaggregation in Patients with Diabetes
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2004-0137
– volume: 22
  start-page: 54
  year: 2011
  ident: ref_20
  article-title: P2Y12 receptor in platelet activation
  publication-title: Platelets
  doi: 10.3109/09537104.2010.497231
– volume: 104
  start-page: 50
  year: 2016
  ident: ref_98
  article-title: Pharmacology and structure of P2Y receptors
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2015.10.030
– volume: 37
  start-page: 1389
  year: 2009
  ident: ref_102
  article-title: Platelets support pulmonary recruitment of neutrophils in abdominal sepsis
  publication-title: Crit. Care Med.
  doi: 10.1097/CCM.0b013e31819ceb71
– volume: 22
  start-page: 686
  year: 2002
  ident: ref_29
  article-title: Role of ADP Receptor P2Y12 in Platelet Adhesion and Thrombus Formation in Flowing Blood
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000012805.49079.23
– volume: 344
  start-page: 231
  year: 2013
  ident: ref_5
  article-title: Prasugrel Metabolites Inhibit Neutrophil Functions
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.112.195883
– volume: 110
  start-page: 141
  year: 2021
  ident: ref_11
  article-title: P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/JLB.3A0220-097R
– volume: 21
  start-page: 475
  year: 2021
  ident: ref_163
  article-title: Effect of ticagrelor on acute kidney injury in septic rats and its underlying mechanism
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2021.9906
– volume: 122
  start-page: 3579
  year: 2012
  ident: ref_16
  article-title: The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI38576
– volume: 110
  start-page: 101
  year: 2022
  ident: ref_151
  article-title: Aspirin and P2Y12 inhibitors in treating COVID-19
  publication-title: Eur. J. Intern. Med.
  doi: 10.1016/j.ejim.2022.11.027
– ident: ref_15
  doi: 10.1371/journal.pone.0026035
– volume: 3
  start-page: 1036
  year: 2005
  ident: ref_26
  article-title: Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2005.01325.x
– volume: 136
  start-page: 557
  year: 2011
  ident: ref_66
  article-title: P2Y1, P2Y6, and P2Y12 receptors in rat splenic sinus endothelial cells: An immunohistochemical and ultrastructural study
  publication-title: Histochem. Cell Biol.
  doi: 10.1007/s00418-011-0859-2
– volume: 96
  start-page: 189
  year: 2005
  ident: ref_101
  article-title: ADP Acting on P2Y13 Receptors Is a Negative Feedback Pathway for ATP Release from Human Red Blood Cells
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000153670.07559.E4
– volume: 36
  start-page: 961
  year: 2016
  ident: ref_12
  article-title: P2Y12 Receptor Modulates Sepsis-Induced Inflammation
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.307401
– volume: 13
  start-page: 952211
  year: 2022
  ident: ref_63
  article-title: Emerging trends and hot spots of NLRP3 inflammasome in neurological diseases: A bibliometric analysis
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2022.952211
– volume: 11
  start-page: 301
  year: 2020
  ident: ref_140
  article-title: P2Y12 Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00301
– volume: 199
  start-page: 72
  year: 2017
  ident: ref_48
  article-title: Critical Role of P2Y12 Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1601549
– volume: 6
  start-page: 1153
  year: 2008
  ident: ref_90
  article-title: The reversible P2Y12 antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2008.03020.x
– volume: 4
  start-page: 129
  year: 2017
  ident: ref_36
  article-title: Platelet–Eosinophil Interactions as a Potential Therapeutic Target in Allergic Inflammation and Asthma
  publication-title: Front. Med.
  doi: 10.3389/fmed.2017.00129
– ident: ref_121
  doi: 10.1371/journal.pone.0069093
– volume: 14
  start-page: 50
  year: 2019
  ident: ref_133
  article-title: The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
  publication-title: Eur. Cardiol. Rev.
  doi: 10.15420/ecr.2018.33.1
– volume: 88
  start-page: 438
  year: 2001
  ident: ref_166
  article-title: Human Platelets Contain a Glycosylated Estrogen Receptor β
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.88.4.438
– ident: ref_105
– volume: 14
  start-page: 111
  year: 2020
  ident: ref_7
  article-title: ADP exerts P2Y12-dependent and P2Y12 -independent effects on primary human T cell responses to stimulation
  publication-title: J. Cell Commun. Signal.
  doi: 10.1007/s12079-019-00540-8
– volume: 105
  start-page: 2531
  year: 2002
  ident: ref_30
  article-title: Functional significance of adenosine 5’-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000016703.93845.AF
– volume: 125
  start-page: 175
  year: 2015
  ident: ref_85
  article-title: Gq-mediated Akt translocation to the membrane: A novel PIP3-independent mechanism in platelets
  publication-title: Blood
  doi: 10.1182/blood-2014-05-576306
– volume: 3
  start-page: 435
  year: 2018
  ident: ref_143
  article-title: Ticagrelor Reduces Thromboinflammatory Markers in Patients With Pneumonia
  publication-title: JACC Basic Transl. Sci.
  doi: 10.1016/j.jacbts.2018.05.005
– volume: 16
  start-page: 217
  year: 2019
  ident: ref_64
  article-title: P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-019-1603-4
– volume: 44
  start-page: 488
  year: 2021
  ident: ref_82
  article-title: Effects of clopidogrel, prasugrel and ticagrelor on prevention of stent thrombosis in patients underwent percutaneous coronary intervention: A network meta-analysis
  publication-title: Clin. Cardiol.
  doi: 10.1002/clc.23536
– volume: 35
  start-page: 25
  year: 2018
  ident: ref_130
  article-title: Ticagrelor inhibits platelet–tumor cell interactions and metastasis in human and murine breast cancer
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-018-9874-1
– volume: 105
  start-page: 3552
  year: 2005
  ident: ref_25
  article-title: P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
  publication-title: Blood
  doi: 10.1182/blood-2004-07-2893
– volume: 35
  start-page: 1805
  year: 2015
  ident: ref_162
  article-title: Ticagrelor Protects the Heart Against Reperfusion Injury and Improves Remodeling after Myocardial Infarction
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.115.305655
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Snippet P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y12 has been...
P2Y 12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y 12 has...
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StartPage 6709
SubjectTerms Blood clots
Cardiovascular disease
Dendritic cells
Immune system
Inflammatory diseases
Kinases
Lymphocytes
Neutrophils
Proteins
Review
Sepsis
Thrombosis
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Title The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges
URI https://www.proquest.com/docview/2799701200
https://www.proquest.com/docview/2800621653
https://pubmed.ncbi.nlm.nih.gov/PMC10095349
Volume 24
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