Effects of the Diacylglycerol Complexing Agent, Cremophor, on Nerve-Conduction Velocity and Perfusion in Diabetic Rats

• Published in: Journal of diabetes and its complications Vol. 13; no. 1; pp. 2 - 9
• Main Authors: Jack, Alison M, Cameron, Norman E, Cotter, Mary A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1999; Elsevier Science
• Subjects: Animals; Associated diseases and complications; Biological and medical sciences; Diabetes Mellitus, Experimental - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies - physiopathology; Diglycerides - metabolism; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Male; Medical sciences; Motor Neurons - drug effects; Motor Neurons - physiology; Nerve Fibers - drug effects; Nerve Fibers - physiology; Neural Conduction - drug effects; Neurons, Afferent - drug effects; Neurons, Afferent - physiology; Peripheral Nerves - physiopathology; Polyethylene Glycols - pharmacology; Rats; Rats, Sprague-Dawley; Sciatic Nerve - physiopathology; Type C Phospholipases - metabolism; United Kingdom; Europe; Endocrinopathy; Animal model; Prostaglandin-endoperoxide synthase; Nervous system diseases; Rat; Enzyme; Pathogenesis; Diabetes mellitus; Rodentia; Diacylglycerol; Enzyme inhibitor; Peripheral neuropathy; Conduction velocity; Biological activity; Nitric-oxide synthase; Nerve conduction; Vertebrata; Mammalia; Complexing agent; Animal; Complication; Peripheral nerve disease; Oxidoreductases; Comparative study

The contribution of diacylglycerol (DAG) and protein kinase C (PKC) to diabetic complications has been the subject of debate. In vascular tissues, diabetes increases DAG content, which activates PKC and causes abnormal tissue perfusion. Reduced nerve blood flow has been implicated in the development...