Free Radical Production Induced by Nitroimidazole Compounds Lead to Cell Death in Leishmania infantum Amastigotes

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 17; p. 4041
• Main Authors: Andrés-Rodríguez, Julia, González-Montero, María-Cristina, García-Fernández, Nerea, Calvo-Álvarez, Estefanía, Pérez-Pertejo, María-Yolanda, Reguera-Torres, Rosa-María, Balaña-Fouce, Rafael, García-Estrada, Carlos
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.08.2024
• Subjects: Animals; Antiparasitic agents; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Cell death; Cell Death - drug effects; Cell Survival - drug effects; Chagas disease; Cytotoxicity; Drug development; Drug dosages; drug repurposing; Free Radicals - metabolism; Hep G2 Cells; High-Throughput Screening Assays; Humans; Leishmania infantum; Leishmania infantum - drug effects; Leishmania infantum - metabolism; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - parasitology; Mice; NADH, NADPH Oxidoreductases; neglected tropical diseases; nitroaromatic compounds; Nitroimidazoles - chemistry; Nitroimidazoles - pharmacology; Parasites; Parasitic diseases; pretomanid; Protozoa; RAW 264.7 Cells; Reactive Oxygen Species - metabolism; Toxicity; Tropical diseases; visceral leishmaniais; Leishmania infantum; nitroaromatic compounds; drug repurposing; fexinidazole; neglected tropical diseases; visceral leishmaniais; trypanothione reductase; pretomanid

Leishmania infantum is the vector-borne trypanosomatid parasite causing visceral leishmaniasis in the Mediterranean basin. This neglected tropical disease is treated with a limited number of obsolete drugs that are not exempt from adverse effects and whose overuse has promoted the emergence of resis...