Free Radical Production Induced by Nitroimidazole Compounds Lead to Cell Death in Leishmania infantum Amastigotes - Andrés-Rodríguez, Julia; González-Montero, María-Cristina; García-Fernández, Nerea; Calvo-Álvarez, Estefanía; Pérez-Pertejo, María-Yolanda; Reguera-Torres, Rosa-María; Balaña-Fouce, Rafael; García-Estrada, Carlos (Molecules (Basel, Switzerland), 2024)
Keywords: Animals; Antiparasitic agents; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Cell death; Cell Death - drug effects; Cell Survival - drug effects; Chagas disease; Cytotoxicity; Drug development; Drug dosages; drug repurposing; Free Radicals - metabolism; Hep G2 Cells; High-Throughput Screening Assays; Humans; Leishmania infantum; Leishmania infantum - drug effects; Leishmania infantum - metabolism; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - parasitology; Mice; NADH, NADPH Oxidoreductases; neglected tropical diseases; nitroaromatic compounds; Nitroimidazoles - chemistry; Nitroimidazoles - pharmacology; Parasites; Parasitic diseases; pretomanid; Protozoa; RAW 264.7 Cells; Reactive Oxygen Species - metabolism; Toxicity; Tropical diseases; visceral leishmaniais; Leishmania infantum; nitroaromatic compounds; drug repurposing; fexinidazole; neglected tropical diseases; visceral leishmaniais; trypanothione reductase; pretomanid