Imidazolopyrazinones as potential antioxidants

A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree...

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Published inBioorganic & medicinal chemistry letters Vol. 11; no. 17; pp. 2305 - 2309
Main Authors Devillers, Ingrid, Dive, Georges, De Tollenaere, Catherine, Falmagne, Bénédicte, de Wergifosse, Bertrand, Rees, Jean-François, Marchand-Brynaert, Jacqueline
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 03.09.2001
Elsevier
Subjects
Antioxidants - chemistry
Antioxidants - metabolism
Antioxidants - pharmacology
Biological and medical sciences
Drug Evaluation, Preclinical
General and cellular metabolism. Vitamins
Imidazoles
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Pyrazines - chemistry
Pyrazoles - chemistry
Reactive Oxygen Species
Structure-Activity Relationship
Superoxides - metabolism
Hyperoxides
Structure activity relation
Angular nitrogen heterocycle
Hartree Fock model
Lactam
Molecular model
Prediction
Bicyclic compound
Antioxidant
Chemical synthesis
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Abstract A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree–Fock instabilities have been examined. A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine (R 1= p-hydroxyphenyl), a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree–Fock instabilities have been examined.
AbstractList A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities have been examined.
A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree–Fock instabilities have been examined. A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine (R 1= p-hydroxyphenyl), a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree–Fock instabilities have been examined.
Author Dive, Georges
Falmagne, Bénédicte
de Wergifosse, Bertrand
Devillers, Ingrid
De Tollenaere, Catherine
Rees, Jean-François
Marchand-Brynaert, Jacqueline
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Issue 17
Keywords Hyperoxides
Structure activity relation
Angular nitrogen heterocycle
Hartree Fock model
Lactam
Molecular model
Prediction
Bicyclic compound
Antioxidant
Chemical synthesis
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Snippet A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active...
A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active...
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SubjectTerms Antioxidants - chemistry
Antioxidants - metabolism
Antioxidants - pharmacology
Biological and medical sciences
Drug Evaluation, Preclinical
General and cellular metabolism. Vitamins
Imidazoles
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Pyrazines - chemistry
Pyrazoles - chemistry
Reactive Oxygen Species
Structure-Activity Relationship
Superoxides - metabolism
Title Imidazolopyrazinones as potential antioxidants
URI https://dx.doi.org/10.1016/S0960-894X(01)00445-0
https://www.ncbi.nlm.nih.gov/pubmed/11527720
https://search.proquest.com/docview/71133215
Volume 11
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