Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells

• Published in: Science advances Vol. 7; no. 33
• Main Authors: Wei, Yanxing, Wang, Tianyu, Ma, Lishi, Zhang, Yanqi, Zhao, Yuan, Lye, Kathryn, Xiao, Lu, Chen, Chunlin, Wang, Zhijian, Ma, Yanlin, Zhou, Xiaohua, Sun, Fei, Li, Weili, Dunk, Caroline, Li, Siliang, Nagy, Andras, Yu, Yanhong, Pan, Guangjin, Lye, Stephen J., Shan, Yongli
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 01.08.2021
• Subjects: Cell Differentiation; Developmental Biology; Female; Genetics; Histones - metabolism; Humans; Placenta; Pluripotent Stem Cells; Pregnancy; SciAdv r-articles; Trophoblasts

A simple and efficient strategy to generate human trophoblast stem cells is reported to aid investigations of early placentation. Human trophoblast stem cells (hTSCs) provide a valuable model to study placental development and function. While primary hTSCs have been derived from embryos/early placen...