Optimization of simulated moving bed plants with low efficient stationary phases: separation of fructose and glucose

• Published in: Journal of Chromatography A Vol. 868; no. 2; pp. 169 - 188
• Main Authors: Beste, York A, Lisso, Mark, Wozny, Günter, Arlt, Wolfgang
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 04.02.2000; Elsevier
• Subjects: Analytical chemistry; Chemistry; Chromatographic methods and physical methods associated with chromatography; Exact sciences and technology; Fructose; Fructose - isolation & purification; Glucose; Glucose - isolation & purification; Other chromatographic methods; Reproducibility of Results; Temperature; Thermodynamics; Simulated moving beds; Glucose; Fructose; True moving beds; Simulated moving bed; Aldose; Preparative chromatography; Ketose; Theoretical study; Separation process; Liquid chromatography; Experimental study; Optimization
• ISSN: 0021-9673
• DOI: 10.1016/S0021-9673(99)01136-X

An optimization procedure for simulated moving bed (SMB) plants with low efficient stationary phases is presented. The new aspect is that the desorbent consumption can be cut by 70% by running the plant with lower internal liquid flows and a corresponding larger switch time while the productivity is kept constant. This concept was validated by the separation of fructose and glucose in water on a calcium resin with an eight-column SMB plant. The separation can be predicted well by a true moving bed (TMB) and a simulated moving bed simulation. Adsorption isotherms were determined up to 300 kg/m 3 for glucose and 500 kg/m 3 for fructose from 25 to 80°C. Experimental SMB runs were performed over a wide range of feed concentrations (10–350 kg/m 3) and temperatures (25–80°C). The strong influence of the delay volume is pointed out. For an experimental run with high feed concentration a complete set of data is presented. To reduce biological growth separation at 80°C is recommended.