Serum half-life time determination of free and total prostate-specific antigen following radical prostatectomy—a critical assessment

• Published in: Urology (Ridgewood, N.J.) Vol. 53; no. 4; pp. 722 - 730
• Main Authors: Brändle, Edgar, Hautmann, Oliver, Bachem, Max, Kleinschmidt, Klaus, Gottfried, Hans Werner, Grünert, Adolf, Hautmann, Richard E
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1999; Elsevier Science
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Half-Life; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Neoplasms - blood; Prostatic Neoplasms - surgery; Serum Albumin - analysis; Tumors of the urinary system; Urinary system; Urinary tract. Prostate gland; Human; Postoperative; Biochemical analysis; Pathophysiology; Indication; Free form; Male; Tumoral marker; Prostate specific antigen; Surgery; Prostatectomy; Kinetics; Half life

Objectives. All studies investigating the elimination kinetics of serum total (tPSA) and free (fPSA) prostate-specific antigen (PSA) were carried out in men undergoing radical prostatectomy. Radical prostatectomy itself could, however, have a major influence on the serum concentration of these tumor...