The neural correlates of 'deaf-hearing' in man : Conscious sensory awareness enabled by attentional modulation

Attentional modulation of normal sensory processing has a two-fold impact on human brain activity: activation of a network of localized brain regions is associated with paying attention, and activation of specific sensory regions is enhanced relative to passive stimulation. The mechanisms underlying...

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Published inBrain (London, England : 1878) Vol. 123; no. 3; pp. 532 - 545
Main Authors ENGELIEN, A, HUBER, W, SILBERSWEIG, D, STERN, E, FRITH, C. D, DÖRING, W, THRON, A, FRACKOWIAK, R. S. J
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.03.2000
Oxford Publishing Limited (England)
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Abstract Attentional modulation of normal sensory processing has a two-fold impact on human brain activity: activation of a network of localized brain regions is associated with paying attention, and activation of specific sensory regions is enhanced relative to passive stimulation. The mechanisms underlying attentional modulation of perception in patients with lesions of sensory cortices are less well understood. Here we report a unique patient suffering from extensive bilateral destruction of the auditory cortices (including the primary auditory fields) who demonstrated conscious perception of the onset and offset of sounds only when selectively attending to the auditory modality. This is the first description of such an attentively modulated 'deaf-hearing' phenomenon and its neural correlates, using H(2)(15)O-PET. Increases in cerebral blood flow associated with conscious awareness of sound that was achieved by listening attentively (compared with identical auditory stimulation presented when the patient was inattentive) were found bilaterally in the lateral (pre)frontal cortices, the spared middle temporal cortices and the cerebellar hemispheres. We conclude that conscious awareness of sounds may be achieved in the absence of the primary auditory cortex, and that selective, 'top-down' attention, associated with prefrontal systems, exerts a crucial modulatory effect on auditory perception within the remaining auditory system.
AbstractList Attentional modulation of normal sensory processing has a two-fold impact on human brain activity: activation of a network of localized brain regions is associated with paying attention, and activation of specific sensory regions is enhanced relative to passive stimulation. The mechanisms underlying attentional modulation of perception in patients with lesions of sensory cortices are less well understood. Here we report a unique patient suffering from extensive bilateral destruction of the auditory cortices (including the primary auditory fields) who demonstrated conscious perception of the onset and offset of sounds only when selectively attending to the auditory modality. This is the first description of such an attentively modulated 'deaf-hearing' phenomenon and its neural correlates, using H(2)(15)O-PET. Increases in cerebral blood flow associated with conscious awareness of sound that was achieved by listening attentively (compared with identical auditory stimulation presented when the patient was inattentive) were found bilaterally in the lateral (pre)frontal cortices, the spared middle temporal cortices and the cerebellar hemispheres. We conclude that conscious awareness of sounds may be achieved in the absence of the primary auditory cortex, and that selective, 'top-down' attention, associated with prefrontal systems, exerts a crucial modulatory effect on auditory perception within the remaining auditory system.
Author STERN, E
DÖRING, W
HUBER, W
SILBERSWEIG, D
FRITH, C. D
FRACKOWIAK, R. S. J
ENGELIEN, A
THRON, A
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Issue 3
Keywords Radionuclide study
Human
Central hearing loss
Nervous system diseases
Stroke
Pathophysiology
Middle cerebral artery
Auditory attention
Auditory disorder
Cardiovascular disease
Retrocochlear hearing loss
Nuclear magnetic resonance imaging
Auditory cortex
Cerebral disorder
Vascular disease
Case study
Central nervous system disease
Medical imagery
Perception hearing loss
Cerebrovascular disease
Positron
Emission tomography
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StartPage 532
SubjectTerms Acoustic Stimulation
Adult
Attention - physiology
Audiometry
Auditory Cortex - blood supply
Auditory Cortex - physiopathology
Biological and medical sciences
Consciousness - physiology
Hearing Loss, Central - diagnostic imaging
Hearing Loss, Central - etiology
Hearing Loss, Central - physiopathology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Neurology
Neuropsychological Tests
Reaction Time - physiology
Stroke - complications
Tomography, Emission-Computed
Vascular diseases and vascular malformations of the nervous system
Volition - physiology
Title The neural correlates of 'deaf-hearing' in man : Conscious sensory awareness enabled by attentional modulation
URI https://www.ncbi.nlm.nih.gov/pubmed/10686176
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