Local anabolic effects of growth hormone on intact bone and healing fractures in rats
The local effects of rat growth hormone (rGH) injected at the surfaces of intact tibial diaphyses and healing tibial diaphysial fractures were investigated in 10-month-old female rats. Intact diaphysial bones: rats were injected daily for 14 days with vehicle, 2 microg rGH, or 20 microg rGH at the s...
Saved in:
Published in | Calcified tissue international Vol. 73; no. 3; pp. 258 - 264 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Springer Nature B.V
01.09.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The local effects of rat growth hormone (rGH) injected at the surfaces of intact tibial diaphyses and healing tibial diaphysial fractures were investigated in 10-month-old female rats. Intact diaphysial bones: rats were injected daily for 14 days with vehicle, 2 microg rGH, or 20 microg rGH at the surface of the right tibial diaphysis. After 10 days of injection the animals were labeled with calcein. At the rGH-injected location, increased external diaphysial bone dimensions and increased calcein-labeled area were seen, and the responses to rGH were dose dependent. The new bone formed at the periosteal surface was woven bone. At the opposite left tibia, no systemic effect of rGH was found. rGH did not influence body weight changes during the treatment, or muscle mass or serum IGF-I at the end of the treatment. Healing diaphysial fractures: a closed fracture was made in the right tibial diaphysis, and stabilized by medullary nailing. The fractures were tested after 21 days and 98 days of healing. During the first 21 days of healing, all rats were injected daily with either vehicle or 20 microg rGH at the surface of the fracture line. In the 21-day healing rGH group, ultimate load, ultimate stiffness, external callus dimensions, and external callus volume of the fractures were increased. rGH did not affect body weight changes during this healing period or serum IGF-I at the end of the healing period. In the 98-day healing rGH group, ultimate load was still increased compared with the vehicle group, although a ninefold increase took place in the vehicle group between days 21 and 98 of healing. External callus dimensions of the fractures were increased in the rGH group, whereas body weight changes during the healing period were not affected. |
---|---|
AbstractList | The local effects of rat growth hormone (rGH) injected at the surfaces of intact tibial diaphyses and healing tibial diaphysial fractures were investigated in 10-month-old female rats. Intact diaphysial bones: rats were injected daily for 14 days with vehicle, 2 microg rGH, or 20 microg rGH at the surface of the right tibial diaphysis. After 10 days of injection the animals were labeled with calcein. At the rGH-injected location, increased external diaphysial bone dimensions and increased calcein-labeled area were seen, and the responses to rGH were dose dependent. The new bone formed at the periosteal surface was woven bone. At the opposite left tibia, no systemic effect of rGH was found. rGH did not influence body weight changes during the treatment, or muscle mass or serum IGF-I at the end of the treatment. Healing diaphysial fractures: a closed fracture was made in the right tibial diaphysis, and stabilized by medullary nailing. The fractures were tested after 21 days and 98 days of healing. During the first 21 days of healing, all rats were injected daily with either vehicle or 20 microg rGH at the surface of the fracture line. In the 21-day healing rGH group, ultimate load, ultimate stiffness, external callus dimensions, and external callus volume of the fractures were increased. rGH did not affect body weight changes during this healing period or serum IGF-I at the end of the healing period. In the 98-day healing rGH group, ultimate load was still increased compared with the vehicle group, although a ninefold increase took place in the vehicle group between days 21 and 98 of healing. External callus dimensions of the fractures were increased in the rGH group, whereas body weight changes during the healing period were not affected. The local effects of rat growth hormone (rGH) injected at the surfaces of intact tibial diaphyses and healing tibial diaphysial fractures were investigated in 10-month-old female rats. Intact diaphysial bones: rats were injected daily for 14 days with vehicle, 2 µg rGH, or 20 µg rGH at the surface of the right tibial diaphysis. After 10 days of injection the animals were labeled with calcein. At the rGH-injected location, increased external diaphysial bone dimensions and increased calcein-labeled area were seen, and the responses to rGH were dose dependent. The new bone formed at the periosteal surface was woven bone. At the opposite left tibia, no systemic effect of rGH was found. rGH did not influence body weight changes during the treatment, or muscle mass or serum IGF-I at the end of the treatment. Healing diaphysial fractures: a closed fracture was made in the right tibial diaphysis, and stabilized by medullary nailing. The fractures were tested after 21 days and 98 days of healing. During the first 21 days of healing, all rats were injected daily with either vehicle or 20 µg rGH at the surface of the fracture line. In the 21-day healing rGH group, ultimate load, ultimate stiffness, external callus dimensions, and external callus volume of the fractures were increased. rGH did not affect body weight changes during this healing period or serum IGF-I at the end of the healing period. In the 98-day healing rGH group, ultimate load was still increased compared with the vehicle group, although a ninefold increase took place in the vehicle group between days 21 and 98 of healing. External callus dimensions of the fractures were increased in the rGH group, whereas body weight changes during the healing period were not affected. |
Author | Andreassen, T T Oxlund, H |
Author_xml | – sequence: 1 givenname: T T surname: Andreassen fullname: Andreassen, T T email: tta@ana.au.dk organization: Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark. tta@ana.au.dk – sequence: 2 givenname: H surname: Oxlund fullname: Oxlund, H |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14667139$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkE1LxDAQhoOsuB_6A7xI8OCtOvlo0h5l8QsWvKzgLaRpstulm6xJi_jvbdkFwcs7zPDMO8M7RxMfvEXomsA9AZAPCYBSlg2aUZA8E2doRjijGRRUTtAMiCRZKeTnFM1T2gEQLoS4QNOxSsLKGfpYBaNbrL2uQtsYbJ2zpks4OLyJ4bvb4m2I--EsDh43vtOmw9XYal_jrdVt4zfYxWHcR5sGAkfdpUt07nSb7NWpLtD6-Wm9fM1W7y9vy8dVZlgJXZaboi44k5xSWgLVnHORM82d4JSZklfWyRJybeqitiVzxnDtXM51XkCVS7ZAd0fbQwxfvU2d2jfJ2LbV3oY-KUl4LoCKAbz9B-5CH_3wmqKEASV5OULkCJkYUorWqUNs9jr-KAJqzFsd81aDqjFvNe7cnIz7am_rv41TwOwX_ht8AA |
CitedBy_id | crossref_primary_10_2106_JBJS_G_01090 crossref_primary_10_3923_ijp_2014_175_181 crossref_primary_10_1016_j_injury_2005_07_019 crossref_primary_10_1016_j_lfs_2023_122204 crossref_primary_10_2106_JBJS_F_00507 crossref_primary_10_1113_jphysiol_2009_179325 crossref_primary_10_1089_teb_2008_0038 crossref_primary_10_1097_ID_0b013e3182096979 crossref_primary_10_1177_19417381241245938 crossref_primary_10_1007_s11657_020_00755_y crossref_primary_10_1302_0301_620X_88B6_17524 crossref_primary_10_3390_jpm10040183 crossref_primary_10_2106_00004623_200611000_00010 crossref_primary_10_1517_13543780902893069 crossref_primary_10_1097_00001665_200403000_00029 crossref_primary_10_3390_ijms20174157 crossref_primary_10_1002_jemt_23140 crossref_primary_10_1016_j_archoralbio_2013_03_018 crossref_primary_10_1016_j_wneu_2019_09_136 crossref_primary_10_1186_1743_7075_2_10 crossref_primary_10_1080_14728222_2016_1188079 crossref_primary_10_2106_JBJS_L_00222 crossref_primary_10_1089_ten_teb_2008_0038 crossref_primary_10_1179_1743132813Y_0000000201 crossref_primary_10_1080_17453670510045318 crossref_primary_10_3389_fneur_2018_00115 |
ContentType | Journal Article |
Copyright | Copyright Springer-Verlag 2003 |
Copyright_xml | – notice: Copyright Springer-Verlag 2003 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QP 7RV 7X7 7XB 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 LK8 M0S M1P M7P NAPCQ PQEST PQQKQ PQUKI PRINS 7X8 |
DOI | 10.1007/s00223-002-2074-6 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest Central Student |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1432-0827 |
EndPage | 264 |
ExternalDocumentID | 709426341 10_1007_s00223_002_2074_6 14667139 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C .55 .86 .VR 06C 06D 0R~ 0VY 199 1N0 2.D 203 23N 28- 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7RV 7X7 88E 8AO 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAEOY AAHNG AAIAL AAJBT AAJKR AANXM AANZL AAQLM AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAWTL AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHXU ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACZOJ ADBBV ADHIR ADIMF ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFFNX AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BKEYQ BPHCQ BVXVI CAG CCPQU CGR COF CS3 CSCUP CUY CVF DDRTE DL5 DNIVK DPUIP EBD EBLON EBS ECM EIF EIOEI EJD EMB EMOBN EN4 ESBYG EX3 F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ IMOTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LK8 LLZTM M1P M4Y M7P MA- N2Q NAPCQ NB0 NDZJH NPM NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R89 R9I RHV RIG RNI RNS ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S37 S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 WOW X7M YLTOR Z45 Z7U Z7V Z7W Z82 Z87 Z8O Z8P Z8Q Z8V Z91 ZGI ZMTXR ZOVNA ~02 ~EX AAYXX CITATION 7QP 7XB 8FK AZQEC DWQXO GNUQQ K9. PQEST PQUKI PRINS 7X8 ABFGW ACWMK AESTI AEVTX AIMYW AKQUC UNUBA |
ID | FETCH-LOGICAL-c390t-5c8d84374222902a444653a4f6423c94bef7905acd8de93fcc4aff54a580b573 |
IEDL.DBID | BENPR |
ISSN | 0171-967X |
IngestDate | Sat Aug 17 02:45:25 EDT 2024 Thu Oct 10 20:23:19 EDT 2024 Thu Sep 12 18:44:05 EDT 2024 Tue Oct 15 23:34:52 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c390t-5c8d84374222902a444653a4f6423c94bef7905acd8de93fcc4aff54a580b573 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 14667139 |
PQID | 213021596 |
PQPubID | 48445 |
PageCount | 7 |
ParticipantIDs | proquest_miscellaneous_71456026 proquest_journals_213021596 crossref_primary_10_1007_s00223_002_2074_6 pubmed_primary_14667139 |
PublicationCentury | 2000 |
PublicationDate | 2003-Sep 2003-9-1 20030901 |
PublicationDateYYYYMMDD | 2003-09-01 |
PublicationDate_xml | – month: 09 year: 2003 text: 2003-Sep |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: New York |
PublicationTitle | Calcified tissue international |
PublicationTitleAlternate | Calcif Tissue Int |
PublicationYear | 2003 |
Publisher | Springer Nature B.V |
Publisher_xml | – name: Springer Nature B.V |
SSID | ssj0014666 |
Score | 1.8734016 |
Snippet | The local effects of rat growth hormone (rGH) injected at the surfaces of intact tibial diaphyses and healing tibial diaphysial fractures were investigated in... |
SourceID | proquest crossref pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 258 |
SubjectTerms | Animals Biomechanical Phenomena Bony Callus - drug effects Bony Callus - metabolism Bony Callus - pathology Dose-Response Relationship, Drug Female Fluoresceins Fracture Healing - drug effects Growth Hormone - administration & dosage Growth Hormone - pharmacology Growth Hormone - therapeutic use Injections, Intralesional Insulin-Like Growth Factor I - analysis Muscle, Skeletal - drug effects Osteogenesis - drug effects Osteogenesis - physiology Rats Rats, Wistar Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Tibia - drug effects Tibia - pathology Tibia - physiopathology Tibial Fractures - drug therapy Tibial Fractures - pathology Tibial Fractures - physiopathology |
Title | Local anabolic effects of growth hormone on intact bone and healing fractures in rats |
URI | https://www.ncbi.nlm.nih.gov/pubmed/14667139 https://www.proquest.com/docview/213021596 https://search.proquest.com/docview/71456026 |
Volume | 73 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NT9wwEB3xIVW9oBb6sUDBB8QByWriOHZ8qqBiWaqCEAJpb5HjxGoPdYBkD_x7Zpzsoh7aS6Qoli3NOJ55fuNngCPEDNZT2WAqtOfSG8Ft7R3Pa1M4LYQropjO1bWa3csf83w-1uZ0Y1nlck2MC3XdOtoj_yqIYcPYq749PHK6NIrI1fEGjXXYFKkklnbz7Pz65nZFI0g1kJWpTrlRer6kNZOoIoqRkdOCIKgmUf0dmP6RbcaoM30HW2O6yE4H_76HtSZsw85pQKj855kds1jAGXfGt-HN1ciT78D9TwpRDNtVpPvLBo3ijrWeXSDu7n-xGeaqbWhYG9hl6K3r2Rm92lAzOpmEAY1N6QDVAuE4-x3Yre27D3A3Pb_7PuPjBQrcZSbpee6KupCZpm0ekwgro5qalR5BR-aMrBpP-lzW1UXdmMw7J633ubR5kVS5zj7CRsCxPwPLjS9UYTF5wz60sDavVdVgduN0pbRIJnCyNF75MMhklCtB5GjpEp8lWbpUE9hbmrcc_5iuXPl3AoerrzjVib-woWkXXalTzPYQM07g0-CT16HQ0Yi2ze5_e96Dt7EUL1aI7cNG_7RovmBK0VcHsK7n-mCcPi9yh8dW |
link.rule.ids | 315,786,790,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB3RIlEuqB8UlpbWB8QByWrWceL4hErVZdvu9oC20t4sx4kFB5xCsgf-PTNOdqse2kukKJEjzTgz73nGzwCfkDNYT22DY6E8l14LbivveFbpwikhXBHFdOa3-fROXi-z5dCb0w5tleuYGAN11ThaIz8TVGHD3Jt_vf_D6dAoKq4OJ2hswUuZppKmuVpu-BbGgL5UOVZjrnO1XBc1k6ghinmRUzgQ1JGYP05LT2DNmHMmu_BmAIvsvPfuHryowz4cnAckyr__sc8stm_GdfF9eDUfquQHcDejBMXwvZJUf1mvUNyyxrPvyLq7n2yKSLUJNWsCuwqddR37Rrc2VIz2JWE6YxPaPrVCMs5-BfbDdu1bWEwuFxdTPhyfwF2qk45nrqgKmSpa5NGJsDJqqVnpkXKkTsuy9qTOZV1VVLVOvXPSep9JmxVJman0ELYDfvs9sEz7Ii8sQjccQwlrsyova8Q2TpW5EskIvqyNZ-57kQyzkUOOljZ4NWRpk4_gaG1eM_wvrdl4dwSnm6c40al6YUPdrFqjxoj1kDGO4F3vk4dPoaORa-sPz458CjvTxXxmZle3N0fwOjblxV6xY9ju_q7qjwguuvIkTqH_zljH9g |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB7xkFAvqOVRFtriA-KAZJF1Ho5PFa_t8hRCIO3NcpxYcMABkj3w7zvjZBf1UC6Roli2NOPMzOcZfwOwh5jBOCobHArpeOKU4KZ0lqelyq0UwuaBTOf6Jhs_JBeTdNJTCjV9WeXMJgZDXdaWzsgPBWXY0Pdmh66virg9Hf1-eeXUQIoSrX03jUVYRicZURcHOZljL7QHXdpyKIdcZXIyS3BGgU8UfSQn0yCoOjH710X9J-4M_mf0FVb7wJEddZr-BguVX4P1I4-g-fmd7bNQyhnOyNdg5brPmK_DwxU5K4bjCmIAZh1bccNqx_4gAm8f2Rij1tpXrPbs3LfGtuyYXo0vGd1RQtfGRnSVaorAnD15dmfaZgPuR2f3J2Pet1LgNlZRy1Obl3kSSzrwUZEwSeBVM4lD-BFblRSVI6YuY8u8rFTsrE2Mc2li0jwqUhlvwpLHtbeApcrlWW4wjMM5pDAmLbOiwjjHyiKTIhrAwUx4-qUjzNBzauQgaY1PTZLW2QB2ZuLV_b_T6LmmB7A7_4qbnjIZxlf1tNFyiHEfoscBfO908rEUKhpxt9r-dOZdWMHdo6_Oby534EuozwtlYz9gqX2bVj8xzmiLX2EH_QU2kcwi |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Local+anabolic+effects+of+growth+hormone+on+intact+bone+and+healing+fractures+in+rats&rft.jtitle=Calcified+tissue+international&rft.au=Andreassen%2C+T+T&rft.au=Oxlund%2C+H&rft.date=2003-09-01&rft.issn=0171-967X&rft.volume=73&rft.issue=3&rft.spage=258&rft.epage=264&rft_id=info:doi/10.1007%2Fs00223-002-2074-6&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0171-967X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0171-967X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0171-967X&client=summon |