Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Pyrin responds to pathogen signals and loss of cellular homeostasis by forming an inflammasome complex that drives the cleavage and secretion of interleukin-1β (IL-1β). Mutations in the B30.2/SPRY domain cause pathogen-independent activation of pyrin and are responsible for the autoinflammatory dise...
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Published in | Science translational medicine Vol. 8; no. 332; p. 332ra45 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
30.03.2016
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Subjects | |
Online Access | Get more information |
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