The Use of Datasets for Theoretical Subjects to Validate Vitamin A–Related Methods and Experimental Designs

• Published in: The Journal of nutrition Vol. 152; no. 3; pp. 707 - 713
• Main Authors: Green, Michael H, Green, Joanne Balmer
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022; Oxford University Press; American Institute of Nutrition
• Subjects: Computer Simulation; Datasets; Dilution; Evaluation; Humans; Kinetics; Metabolism; model-based compartmental analysis; Models, Biological; Nutrients; Nutrition; Perturbation; Pharmacokinetics; Research Design; Retinene; retinol isotope dilution; Simulation; Steady state; theoretical human subjects; Vitamin A; vitamin A assessment; Vitamin A Deficiency; Vitamin D; Vitamin deficiency; WinSAAM; retinol isotope dilution; vitamin A assessment; RBP; TBS; theoretical human subjects; model-based compartmental analysis; WinSAAM; RID

We review recent work in which model-based compartmental analysis has been applied to data for theoretical human subjects in order to study questions related to vitamin A kinetics and metabolism. Using model simulations in this way, one can validate experimental designs, evaluate or improve vitamin...