A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria

• Published in: European journal of pharmacology Vol. 576; no. 1; pp. 122 - 131
• Main Authors: Wolkowicz, Paul E., Grenett, Hernan E., Huang, Jian, Wu, Hsien Chin, Ku, David D., Urthaler, Ferdinand
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 08.12.2007; Elsevier
• Subjects: 2-APB; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology; Animals; Atrial fibrillation; Atrial tachycardia; Benzazepines - pharmacology; Biological and medical sciences; Boron Compounds - pharmacology; Calcium - physiology; Calcium Channel Agonists - pharmacology; Cardiac dysrhythmias; Cardiology. Vascular system; Cardiotonic Agents - pharmacology; Cyclic Nucleotide-Gated Cation Channels - genetics; Heart; Heart Atria - drug effects; Heart Atria - metabolism; Heart Atria - physiopathology; I f; In Vitro Techniques; Male; Medical sciences; Na/Ca-exchanger; Ouabain - pharmacology; Pharmacology. Drug treatments; Pyrimidines - pharmacology; Pyrroles - pharmacology; Rats; Rats, Sprague-Dawley; RNA, Messenger - metabolism; Ryanodine - pharmacology; Tachycardia - chemically induced; Tachycardia - drug therapy; Tachycardia - physiopathology; Atrial tachycardia; Na/Ca-exchanger; Atrial fibrillation; 2-APB; I f; Arrhythmia; Calcium; Rat; Rodentia; Cardiovascular disease; Inorganic element; Excitability disorder; Vertebrata; Mammalia; Na; Heart disease; Animal; exchanger; Models; If; Ca

Few experimental models produce spontaneous tachycardia in normal left atria to allow the study of the cellular mechanisms underlying this contributor to atrial fibrillation. We reported 2-aminoethoxydiphenyl borate (2-APB) that provokes sporadic spontaneous mechanical activity and calcium leak in i...